How many clinical trials are tracked for Septic Shock?

39 trials are tracked, 5 with published results.

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Septic Shock

Part of Systemic Inflammatory Response Syndrome

Subtypes of Septic Shock

Endotoxic septic shock 1

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Septic Shock

39 trials tracked for Septic Shock: 8 in phase 3 or 4 and 5 with published results. The most-cited published study has 346 citations.

39Trials tracked

8Phase 3 & 4

0Recruiting

5With published results

Phase distribution

Phase 4 3 Phase 3 5 Phase 2 17 Phase 1 2 Other / NA 12

Phase 3 Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis Completed · 346 cited
Phase 3 Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial Completed · 248 cited
Phase 4 The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial Completed · 110 cited
Phase 3 Statin Therapy in the Treatment of Sepsis Completed · 62 cited
Phase 3 Vitamin C and Septic Shock Completed · 61 cited
Phase 4 Renin and Renal Biomarker Response to Angiotensin II Completed

Show 33 more trials

Phase 4 Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock Completed
Phase 3 Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock Completed
Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis Completed
Phase 2 A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock Completed
Phase 2 Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia Completed
Phase 2 Rapid Administration of Carnitine in sEpsis Completed
Phase 2 LIPIDS-P Trial Phase I/II Trial Completed
Phase 2 Thiamine as a Metabolic Resuscitator in Septic Shock Completed
Phase 2 A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock Completed
Phase 2 HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients Completed
Phase 2 Acetyl-L-Carnitine in the Treatment of Septic Shock Completed
Phase 2 Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock Completed
Phase 2 Effects of the V1a Agonist FE 202158 in Patients With Septic Shock Completed
Phase 2 Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. Completed
Phase 2 Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB Completed
Phase 2 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients With Septic Shock Completed
Phase 2 A Trial of Vitamin B12 in Septic Shock Completed
Phase 2 Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock Completed
Phase 2 Vitamin C & Thiamine to Treat Sepsis and Septic Shock Completed
Phase 1 Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study Completed
Phase 1 Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study Completed
N/A Protocolized Care for Early Septic Shock Completed
N/A Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM) Completed
N/A Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock Completed
N/A The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation Completed
N/A Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock Completed
N/A Early Warning System for Clinical Deterioration on General Hospital Wards Completed
N/A Release of Nociceptin From Granulocytes in Sepsis Completed
N/A Initiation of Hydrocortisone for the Treatment of Septic Shock Completed
N/A Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock Completed
N/A Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department Completed
N/A High MAP in Septic Shock With Hypertension Completed
N/A PK Analysis of Piperacillin in Septic Shock Patients Completed

Showing the 39 most-cited and recently-updated of 39 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Questions about Septic Shock

Do doctors need to give extra oxygen to patients with septic shock?

Yes, doctors often give extra oxygen to septic shock patients, but recent evidence shows conservative oxygen targets (SpO2 88-94%) are as safe as liberal targets, with no difference in mortality.

Full answer →

Is it better to have high or low pulse pressure when you have septic shock?

In septic shock, a pulse pressure between 40-70 mmHg during the first 24 hours is linked to lower 28-day mortality; both very low and very high pulse pressure are associated with worse outcomes.

Full answer →