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Home › Conditions › Suicide

Suicide

Subtypes of Suicide

Suicidal Ideation 11 Suicide attempt 3

32 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Suicide

64 trials tracked for Suicide: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 124 citations.

64Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 2 2 Other / NA 61
  1. Phase 4 Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder Completed · 124 cited
  2. Phase 2 Ketamine for Depression and Suicide Risk Completed
  3. Phase 2 Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents Completed
  4. N/A Southwest Hub for American Indian Youth Suicide Prevention Research Completed
  5. N/A Mindfulness-Based Cognitive Therapy for Suicide Prevention Completed
  6. N/A Developing Text-based Support for Parents of Adolescents After an Emergency Department Visit Completed
Show 44 more trials
  1. N/A Family Safety Net - Aim 3: Randomized Control Trial Completed
  2. N/A Suicide Safety Planning Group Treatment: "Project Life Force" Completed
  3. N/A Peer Based Suicide Prevention Completed
  4. N/A Technology-Assisted Systems Change for Suicide Prevention Completed
  5. N/A SAFER: A Brief Intervention Involving Family Members in Suicide Safety Planning Completed
  6. N/A Increasing Treatment Seeking Among Suicidal Veterans Calling the Crisis Line Completed
  7. N/A ACT for Life: a Brief Intervention for Maximizing Recovery After Suicidal Crises Completed
  8. N/A Veterans Coping Long-term With Active Suicide Completed
  9. N/A Drivers of Suicide Mobile App Study Completed
  10. N/A Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms Completed
  11. N/A Preventing Addiction Related Suicide (PARS) Completed
  12. N/A Window to Hope-Evaluating a Psychological Treatment for Hopelessness Among Veterans With Traumatic Brain Injury Completed
  13. N/A Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs Completed
  14. N/A Suicide Prevention for Sexual and Gender Minority Youth (Case Series) Completed
  15. N/A Circle of Life. Improving Capacity of Swampy Cree Community Members to Recognize People at Risk for Suicide Completed
  16. N/A CAMS-RAS: for Suicide Prevention Completed
  17. N/A Adaptive Implementation Intervention for VA Suicide Risk Identification Strategy Completed
  18. N/A Nurse Suicide: Physiologic Sleep Health Promotion Trial Completed
  19. N/A A Digital Game Targeting Suicide Prevention in Adolescents Who Report Substance Misuse Completed
  20. N/A Suicide Prevention Intervention for Vulnerable Emerging Adult Sexual Minorities Completed
  21. N/A eLearning for Suicide Prevention Completed
  22. N/A 5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression Completed
  23. N/A Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop Completed
  24. N/A Pilot of Training on 988 and Narcan Completed
  25. N/A Pilot RCT of a Video-based Intervention for Suicide Prevention Completed
  26. N/A Developing a Mobile Intervention to Reduce Suicidal Cognitions in Veterans Completed
  27. N/A Crisis Line Facilitation Completed
  28. N/A PracticeGround: Transforming Training and Delivery of Mental Health EBPs Completed
  29. N/A Development of a Video-based Intervention for Suicide Prevention Completed
  30. N/A Trauma Survivors Outcomes and Support Study IV Completed
  31. N/A Emergency Room Firearm and Medication Safety Intervention Completed
  32. N/A Coping Long Term With Attempted Suicide - Adolescents Completed
  33. N/A Group ("Project Life Force") vs. Individual Suicide Safety Planning RCT Completed
  34. N/A Patient and Provider Outcomes of E-Learning Training in Collaborative Assessment and Management of Suicidality Completed
  35. N/A CAMPUS - Feasibility Sub-Study Completed
  36. N/A Concurrent Treatment for Depressed Parents and DepressedAdolescents Completed
  37. N/A Digital Youth-Nominated Support Team (YST) Program Completed
  38. N/A Cognitive Behavioral Suicide Prevention for Psychosis: Aim 1 Completed
  39. N/A "Safety in Dementia": An Online Caregiver Intervention Completed
  40. N/A An Adaptive Intervention for Adolescents at Risk for Suicide: A Pilot SMART Completed
  41. N/A Practice Experiences for School Reintegration Completed
  42. N/A TMS for Suicidal Crisis in Active Duty SMs Completed
  43. N/A Developing Adaptive Interventions for Suicidal College Students Seeking Treatment - SMART Completed
  44. N/A Suicide Prevention for Sexual and Gender Minority Youth (Open Trial) Completed

Showing the 50 most-cited and recently-updated of 64 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Suicide: what the trials found

Pharmacological management for suicide risk includes the use of Fluoxetine (Phase 4) 10.

Evidence regarding specific behavioral interventions such as Project Life Force did not show statistically significant changes in outcomes measured by the Columbia Suicide Rating Scale, Beck Depression Inventory-II, or Beck Hopelessness Scale 14.

Recent results — preliminary, needs further review

  • The BE-SMART-DR intervention showed statistically significant improvements in scores for suicidal ideation/propensity (CHRT-SR, p=0.0008; SSI, p=<.0001) and daily rhythms (BSRS, p=0.0002) 4.
  • Implementation of eScreening significantly increased the rates of PTSD, depression (PHQ-2), and alcohol (AUDIT) screenings compared to standard practice (p=<.001) 8.
  • Safety Planning interventions were evaluated for duration and fidelity; 100% of adolescent participants received intervention with at least 80% fidelity 15.
  • The eYST website demonstrated high usability scores across youth (68.3), adult caregivers (75.6), and adult support participants (79.5) 6.
  • Other recently investigated but not yet corroborated interventions include MI FSN - Lethal Means Reduction 1, Safety in Dementia 2, WisePath for Adults 3, Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) 5, Crisis Ready Training 7, New Hope (NH) 9, and Problem-solving treatment 18.

For the clinician treating this condition

  • Fluoxetine is an established pharmacological option in the context of suicide risk management 10.
  • The BE-SMART-DR intervention demonstrated significant efficacy in reducing suicidal ideation/propensity and improving daily rhythms 4.
  • eScreening systems are effective for increasing the identification rates of comorbid conditions such as depression, PTSD, and alcohol use 8.

AI synthesis of 13 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Report describes suicides among American Indian or Alaska Native persons in the United States
Psychiatry
Report describes suicides among American Indian or Alaska Native persons in the United States What do we know about suicide among American Indian and Alaska Native people?
An observational report describes suicides among American Indian or Alaska Native persons in the United States.
A new report documents suicides among American Indian and Alaska Native persons during 2015-2020, highlighting an urgent need for better sup…
CDC Apr 3, 2026
CDC Updates Guidance for Assessing and Responding to Suicide Clusters in Communities
Psychiatry
CDC Updates Guidance for Assessing and Responding to Suicide Clusters in Communities How should communities respond when suicides cluster together?
The CDC has released updated guidance for communities to assess, investigate, and respond to suicide clusters.
When suicides happen close together in time or place, communities need clear steps to investigate links and support those affected to preven…
CDC Apr 3, 2026
Updated guidance released for community response to suicide clusters in the United States
Psychiatry
Updated guidance released for community response to suicide clusters in the United States How should communities respond when suicide clusters happen? New guidance offers help
A new guidance document outlines updated recommendations for community response to suicide clusters in the United States.
New guidance helps U.S. communities respond to suicide clusters with a practical roadmap for leaders and first responders.
CDC Apr 3, 2026
Observational study describes age-adjusted suicide rates in the US by urbanization and sex
Psychiatry
Observational study describes age-adjusted suicide rates in the US by urbanization and sex How do suicide rates differ between cities and rural areas?
An observational study described age-adjusted suicide rates in the United States population, stratified by urbanization level and sex.
Suicide rates in the United States differ by whether a community is urban or rural, and between men and women, according to a new analysis o…
CDC Apr 3, 2026
Firearm suicide rates increased in US population from 2019 through 2022
Psychiatry
Firearm suicide rates increased in US population from 2019 through 2022 Firearm suicide rates increased in the United States from 2019 through 2022
An observational report of US population data from 2019 through 2022 found increases in firearm suicide rates.
Firearm suicide rates in the United States increased from 2019 through 2022, highlighting a growing public health concern that requires more…
CDC Apr 3, 2026
U.S. suicide rates from 2018-2023 show differences by race, ethnicity, and age
Psychiatry
U.S. suicide rates from 2018-2023 show differences by race, ethnicity, and age Who is most at risk for suicide? New report reveals differences by age and race
An observational report of U.S. population suicide rates from 2018-2023 found differences by race, ethnicity, and age group.
A new report shows suicide rates in America vary by age and race, proving the risk isn't spread evenly across the population.
CDC Apr 3, 2026
U.S. age-adjusted suicide rate was 14.0 per 100,000 population in 2017 surveillance data
Psychiatry
U.S. age-adjusted suicide rate was 14.0 per 100,000 population in 2017 surveillance data U.S. suicide rate was 14 per 100,000 people in 2017, new data shows
A 2017 U.S. vital statistics surveillance report found the national age-adjusted suicide rate was 14.0 per 100,000 population.
In 2017, the U.S. age-adjusted suicide rate was 14.0 per 100,000 people, marking a serious public health challenge that needs attention.
CDC Apr 3, 2026
Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD
Psychiatry RCT
Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD Study protocol tests brain stimulation for depression with suicidal thoughts
This is a study protocol for a single-blind RCT of 56 adults with major depressive disorder and active suicidal ideation.
A new brain stimulation treatment is being tested to reduce depression and suicidal thoughts in adults, using magnetic pulses over 10 sessio…
Frontiers Apr 1, 2026