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Home › Conditions › Colorectal Cancer

Colorectal Cancer

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Colorectal Cancer

532 trials tracked for Colorectal Cancer: 78 in phase 3 or 4 and 32 with published results. The most-cited published study has 2934 citations.

532Trials tracked
78Phase 3 & 4
0Recruiting
32With published results
Phase distribution
Phase 4 14 Phase 3 64 Phase 2 252 Phase 1 41 Other / NA 161
  1. Phase 3 Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177) Completed · 2,934 cited
  2. Phase 3 Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies Completed · 1,423 cited
  3. Phase 3 Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Rectal Cancer Completed · 1,092 cited
  4. Phase 3 A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370) Completed · 559 cited
  5. Phase 3 Adjuvant HIPEC in High Risk Colon Cancer Completed · 318 cited
  6. Phase 3 A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Participants With Metastatic Colorectal Cancer Completed · 317 cited
Show 44 more trials
  1. Phase 3 A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combination Chemotherapy (FOLFOX-4) With or Without Cetuximab in the 1st Line Treatment of Metastatic Colorectal Cancer (mCRC) in Chinese Rat Sarcoma Viral Oncogene Homolog (RAS) Wild-type Patients Completed · 257 cited
  2. Phase 3 Study of Trifluridine/Tipiracil (TAS-102) in Patients With Metastatic Colorectal Cancer in Asia Completed · 255 cited
  3. Phase 3 Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC Completed · 254 cited
  4. Phase 3 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed · 235 cited
  5. Phase 3 BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma Completed · 168 cited
  6. Phase 3 Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults. Completed · 111 cited
  7. Phase 3 Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults Completed · 95 cited
  8. Phase 3 Efficacy of Morning-only Bowel Preparation for Afternoon Colonoscopy. Completed · 85 cited
  9. Phase 3 The Safety and Efficacy of Methylene Blue MMX® Modified Release Tablets Administered to Subjects Undergoing Screening or Surveillance Colonoscopy Completed · 84 cited
  10. Phase 3 Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017) Completed · 76 cited
  11. Phase 3 An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread Completed · 67 cited
  12. Phase 3 Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Completed · 64 cited
  13. Phase 3 Nintedanib (BIBF 1120) vs Placebo in Refractory Metastatic Colorectal Cancer (LUME-Colon 1) Completed · 64 cited
  14. Phase 3 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Completed · 42 cited
  15. Phase 4 The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery Completed · 36 cited
  16. Phase 4 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed · 35 cited
  17. Phase 3 Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer Completed · 34 cited
  18. Phase 4 Comparative Efficacy of Water & Indigo Carmine vs. Water or Air Method on Adenoma Detection Rate (ADR) - a Randomized Controlled Trial (RCT) Completed · 31 cited
  19. Phase 4 Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®) Completed · 25 cited
  20. Phase 3 Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer Completed · 25 cited
  21. Phase 4 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed · 18 cited
  22. Phase 3 Comparing Efficacy and Safety of Stivant (AryoGen Bevacizumab) Versus Avastin in Metastatic Colorectal Cancer Completed · 15 cited
  23. Phase 3 Efficacy and Safety of Olaparib (MK-7339) With or Without Bevacizumab Compared to Bevacizumab With a Fluoropyrimidine in Unresectable or Metastatic Colorectal Cancer (CRC) (MK-7339-003/LYNK-003) Completed · 13 cited
  24. Phase 3 A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007) Completed · 4 cited
  25. Phase 3 S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 Completed · 3 cited
  26. Phase 3 Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults. Completed
  27. Phase 4 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed
  28. Phase 4 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed
  29. Phase 4 Patient Satisfaction With Propofol for Out Patient Colonoscopy Completed
  30. Phase 4 Glucagon Use in Colonoscopies Completed
  31. Phase 4 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Completed
  32. Phase 4 Comparative Effectiveness of Split-Dose Colonoscopy Bowel Preparation Regimens Completed
  33. Phase 4 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed
  34. Phase 4 Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum Completed
  35. Phase 4 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed
  36. Phase 3 Comparison of Survival Benefit of Panitumumab With Supportive Care to Best Supportive Care Alone in Patients With Metastatic Colorectal Cancer Completed
  37. Phase 3 A Study of Xeloda (Capecitabine) Compared With 5-Fluorouracil in Combination With Low-Dose Leucovorin in Patients Who Have Undergone Surgery for Colon Cancer Completed
  38. Phase 3 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum. Completed
  39. Phase 3 Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer Completed
  40. Phase 3 A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer Completed
  41. Phase 3 Rifaximin and Placebo in the Treatment of Bowel Dysfunction After Anterior Resection for Rectal Cancer Completed
  42. Phase 3 A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study Completed
  43. Phase 3 Initial Attack on Latent Metastasis Using TAS-102 for ct DNA Identified Colorectal Cancer Patients After Curative Resection Completed
  44. Phase 3 A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer Completed

Showing the 50 most-cited and recently-updated of 532 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Network meta-analysis shows image-enhanced endoscopy methods improve adenoma detection rates compared to high-definition white light imaging in colorectal lesion screening
Gastroenterology Meta-analysis
Network meta-analysis shows image-enhanced endoscopy methods improve adenoma detection rates compared to high-definition white light imaging in colorectal lesion screening New Camera Tech Finds More Colon Cancer Clues
This network meta-analysis of randomized controlled trials involving 28,663 participants evaluated image-enhanced endoscopy (IEE) methods ag…
A new camera tech helps doctors spot hidden colon cancer clues that standard scopes often miss during routine checkups.
Apr 14, 2026
Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis
Gastroenterology Meta-analysis
Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis Robots Are Removing Colon Cancer and Liver Tumors in One Operation
This single-arm meta-analysis included 165 patients aged 18 or older with synchronous colorectal cancer and liver metastases.
Robotic surgery safely removes colon cancer and liver tumors in one operation, sparing some patients a second major procedure.
Apr 14, 2026
Immunonutrition supplementation significantly shortened time to first flatus in colorectal cancer surgery patients
Nutrition & Obesity Medicine Meta-analysis
Immunonutrition supplementation significantly shortened time to first flatus in colorectal cancer surgery patients Eating Special Food Speeds Up Gut Recovery After Surgery
This systematic review and meta-analysis of randomized controlled trials evaluated immunonutrition supplementation in 2,367 patients undergo…
A special mix of nutrients given before and after surgery helps your stomach wake up faster, letting you eat normally sooner.
Frontiers Apr 10, 2026
Intratumoral H101 plus total neoadjuvant therapy yields pathologic complete response in one patient with metachronous locally advanced rectal cancer
Oncology RCT
Intratumoral H101 plus total neoadjuvant therapy yields pathologic complete response in one patient with metachronous locally advanced rectal cancer Could a virus help save a patient's rectal cancer and their ability to use the bathroom?
This case report describes a 50-year-old patient with metachronous locally advanced rectal cancer treated with intratumoral injection of rec…
A virus combined with standard therapy helped a 50-year-old man clear his rectal cancer while keeping his bowel control intact.
Frontiers Apr 9, 2026
Dynamic ctDNA monitoring during neoadjuvant chemotherapy identifies high-risk rectal cancer patients
Gastroenterology RCT
Dynamic ctDNA monitoring during neoadjuvant chemotherapy identifies high-risk rectal cancer patients Blood test during chemo may help predict rectal cancer treatment response
A biomarker substudy of a multicenter RCT in 153 patients with low-/intermediate-risk locally advanced rectal cancer found that dynamic ctDN…
A blood test tracking tumor DNA during chemo can predict which rectal cancer patients won't respond well to treatment before surgery.
Apr 8, 2026
Meta-analysis links higher BMI to increased early-onset colorectal cancer risk
Gastroenterology Meta-analysis
Meta-analysis links higher BMI to increased early-onset colorectal cancer risk Does weight affect colon cancer risk in younger adults? A new analysis finds a link
A systematic review and meta-analysis of 11 cohort studies found that overweight/obesity (BMI ≥25 kg/m²) was associated with higher early-on…
Being overweight or obese is linked to a 59% higher risk of colon cancer before age 50, with men and those with obesity facing the greatest …
Apr 8, 2026
Nurse-led music intervention shows preliminary benefit for cognitive impairment in colorectal cancer patients
Gastroenterology RCT
Nurse-led music intervention shows preliminary benefit for cognitive impairment in colorectal cancer patients Can listening to your favorite music help clear cancer treatment brain fog?
A pilot RCT of 70 colorectal cancer patients with cognitive impairment found a 9-week nurse-led individualized music-listening intervention …
Listening to favorite music helped colorectal cancer patients feel less brain fog, depression, and fatigue while sleeping better during trea…
Apr 5, 2026
Computational framework reconstructs multidimensional clinical profiles from published Kaplan-Meier images
Oncology RCT
Computational framework reconstructs multidimensional clinical profiles from published Kaplan-Meier images Can a computer reconstruct hidden patient stories from old cancer trial charts?
Methodological research using simulated data and empirical cancer cohorts (n=228 lung, n=929 colon) evaluated the MD-JoPiGo framework.
A new tool reconstructs hidden patient stories from old cancer trial charts, revealing how age and tumor markers interacted using only stand…
medRxiv Apr 4, 2026

Questions about Colorectal Cancer

How do specific mutations affect treatment response in Colorectal Cancer?

Specific mutations like KRAS, BRAF, and MMR status strongly influence treatment response in colorectal cancer, guiding targeted therapy and immunotherapy decisions.

Full answer →
What factors affect the quality of life for survivors of Colorectal Cancer?

Quality of life for colorectal cancer survivors is influenced by physical symptoms, psychological distress, social support, self-efficacy, and demographic factors like age and gender.

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How does gut microbiota relate to the development of Colorectal Cancer?

Gut microbiota imbalances, including harmful bacteria like Fusobacterium nucleatum, can promote colorectal cancer through inflammation, DNA damage, and immune disruption, while beneficial microbes may offer protection.

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What are the challenges of using artificial intelligence for Colorectal Cancer treatment?

AI in colorectal cancer treatment faces challenges including data quality and privacy issues, lack of generalizability, interpretability problems, and regulatory validation hurdles.

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Can home exercise help reduce fatigue and anxiety in Colorectal Cancer patients?

Yes, home exercise may help reduce fatigue and anxiety in colorectal cancer patients, but the evidence is low certainty and more research is needed.

Full answer →
See all 5 questions about Colorectal Cancer →