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Home › Conditions › Dementia

Dementia

Subtypes of Dementia

Alzheimer's Disease 105 Dementia with Lewy bodies 6 Vascular Dementia 5 Huntington's Disease 4 Frontotemporal dementia 3 Amnestic dementia 1 Lewy body disorders 1 Young-onset dementia 1 Dementia epileptica 0

149 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dementia

202 trials tracked for Dementia: 16 in phase 3 or 4 and 6 with published results. The most-cited published study has 70 citations.

202Trials tracked
16Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 8 Phase 3 8 Phase 2 15 Phase 1 5 Other / NA 166
  1. Phase 3 The Healthy Patterns Sleep Study Completed · 70 cited
  2. Phase 4 Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA) Completed · 36 cited
  3. Phase 3 Preventing Aggression in Veterans With Dementia Completed · 28 cited
  4. Phase 3 Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Completed · 28 cited
  5. Phase 4 Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation Completed · 15 cited
  6. Phase 4 Monitoring Anti-Dementia Drugs by Serum Levels Completed
Show 44 more trials
  1. Phase 4 Corticolimbic Degeneration and Treatment of Dementia Completed
  2. Phase 4 The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life Completed
  3. Phase 4 Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT) Completed
  4. Phase 4 Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study Completed
  5. Phase 4 Antidepressant Medication Plus Donepezil for Treating Late-life Depression Completed
  6. Phase 3 Preventing Loss of Independence Through Exercise (PLIE) in Persons With Dementia Completed
  7. Phase 3 Cholinesterase Inhibitor Discontinuation Completed
  8. Phase 3 Renew NCP-5 for the Treatment of Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild Dementia of the Alzheimer's Type Completed
  9. Phase 3 Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II) Completed
  10. Phase 3 Ginkgo Biloba Prevention Trial in Older Individuals Completed
  11. Phase 2 A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD Completed
  12. Phase 2 A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease Completed
  13. Phase 2 iCare Stress Management e-Training for Dementia Family Caregivers Completed
  14. Phase 2 A Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With Early Alzheimer's Disease Completed
  15. Phase 2 Development of NIC5-15 in the Treatment of Alzheimer's Disease Completed
  16. Phase 2 Effect of Insulin Sensitizer Metformin on AD Biomarkers Completed
  17. Phase 2 A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD) Completed
  18. Phase 2 Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease Completed
  19. Phase 2 Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease Completed
  20. Phase 2 Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease Completed
  21. Phase 2 A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment Completed
  22. Phase 2 Sub-Lingual Dexmedetomidine in Agitation Associated With Dementia Completed
  23. Phase 2 LifeZig Personalized Reminiscence Video With Slideshows and Music for Individuals With Alzheimer's and Dementia Completed
  24. Phase 2 A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT) Completed
  25. Phase 2 A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD) Completed
  26. Phase 1 Home Safety Clinical Trial for Alzheimer's Disease Completed
  27. Phase 1 The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression Completed
  28. Phase 1 Encouraging Cognitive Screenings at African American Churches Completed
  29. Phase 1 The Interaction Between Diabetes and Estradiol on Human Brain Metabolism in Postmenopausal Women Completed
  30. Phase 1 Feasibility of a Systems Approach for Alzheimer's Services Among Latinos Attending Primary Care Practices Completed
  31. N/A Mobile Tablet Education to Advance Caregiver Health Completed
  32. N/A Savvy System Project Completed
  33. N/A SimpleC Wellness Platform With Social Robot Interaction Completed
  34. N/A Movement Intervention for Memory Enhancement Completed
  35. N/A Moving Together: An Online Group Movement Program for People Living With Memory Loss and Caregivers Completed
  36. N/A Program of Intensive Support in Emergency Departments for Care Partners of Cognitively Impaired Patients Completed
  37. N/A Care Partner Assisted Intervention to Improve Oral Health of Individuals With Mild Dementia Completed
  38. N/A Can Value Champions Reduce Inappropriate Prescribing for People With Dementia? Completed
  39. N/A User-Led Meaningful Activity and Early-Stage Dementia Completed
  40. N/A Aggression Prevention Training for Caregivers of Persons With Dementia (APT) Completed
  41. N/A Delivery Models of Caregiver Support and Education Completed
  42. N/A Music Based Caregiving in Patients With Pain and Dementia Completed
  43. N/A Pragmatic Trial of Video Education in Nursing Homes Completed
  44. N/A A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research Completed

Showing the 50 most-cited and recently-updated of 202 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Review organizes pharmacological strategies targeting gut-brain axis for neurological and psychiatric disorders
Neurology Sys. Review
Review organizes pharmacological strategies targeting gut-brain axis for neurological and psychiatric disorders Could targeting gut health help treat brain disorders?
A systematic review summarizes mechanisms of microbiota–gut–brain axis dysfunction and organizes existing pharmacological strategies for con…
Treating brain disorders like Parkinson's and depression may involve targeting the gut-brain connection to reduce shared inflammation.
Frontiers Apr 2, 2026
Pilot RCT: Telehealth palliative care model may reduce hospital visits in dementia patients
Palliative Care RCT
Pilot RCT: Telehealth palliative care model may reduce hospital visits in dementia patients Could a few telehealth conversations help people with dementia avoid the hospital?
A pilot randomized controlled trial of 51 persons living with dementia and their caregivers found that a Telehealth-Facilitated Integrated P…
A small study found that telehealth conversations with palliative care specialists significantly reduced emergency visits and hospitalizatio…
Apr 2, 2026
Anosognosia and Theory of Mind Deficits Independently Associated with Caregiver Distress in Dementia
Neurology
Anosognosia and Theory of Mind Deficits Independently Associated with Caregiver Distress in Dementia Why do some dementia caregivers feel more distress? Two key patient traits may explain it
A cross-sectional secondary analysis of 205 participants with various dementia syndromes found that anosognosia and theory of mind deficits …
When a person with dementia lacks awareness of their decline or struggles to understand others, it adds up to greater distress for their car…
Frontiers Apr 1, 2026
Meta-analysis finds Icariin improves cognition in Alzheimer's animal models at 68 mg/kg dose
Neurology Meta-analysis
Meta-analysis finds Icariin improves cognition in Alzheimer's animal models at 68 mg/kg dose Icariin compound shows promise for improving memory in Alzheimer's animal studies
A systematic review and meta-analysis of 31 preclinical studies in Alzheimer's disease animal models found Icariin treatment significantly i…
A natural compound called Icariin improved memory and thinking in animal models of Alzheimer's disease by protecting brain cells from damage…
Apr 1, 2026
mHealth program reduces caregiver burden for dementia-diabetes caregivers in RCT
Diabetes & Endocrinology RCT
mHealth program reduces caregiver burden for dementia-diabetes caregivers in RCT Can a smartphone app ease the crushing burden of caring for a loved one with both dementia and diabetes?
A 12-week mHealth supportive care program for family caregivers of individuals with dementia and type 2 diabetes significantly reduced careg…
A smartphone app helped family caregivers feel significantly less burdened and more supported while caring for a loved one with both dementi…
Mar 30, 2026

Questions about Dementia

Can brain scans show how my dementia is causing my memory to fade?

Yes, brain scans can show patterns of shrinkage and damage linked to memory loss in dementia, but they are one piece of a broader diagnostic picture.

Full answer →
Are there new genetic markers for Alzheimer disease found in veteran populations?

Yes, a meta-analysis of the VA Million Veterans Program identified 17 new genetic loci in European, 4 in African, and 3 in Hispanic veteran populations for Alzheimer's disease.

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Can taking cannabinoids help reduce agitation in severe dementia cases?

Yes, cannabinoids may reduce agitation in severe dementia, but they increase sedation risk and evidence is limited.

Full answer →
Will walking while doing a task make me move slower if I have dementia?

Yes, walking while doing a task (dual-tasking) makes people with dementia move slower and take shorter steps compared to walking without a task.

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Do antipsychotic drugs increase the risk of death for people with dementia?

Yes, antipsychotic drugs significantly increase the risk of death for people with dementia, with a pooled hazard ratio of 1.32 in a large meta-analysis.

Full answer →
See all 5 questions about Dementia →