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Home › Conditions › Hepatitis B

Hepatitis B

Part of Hepatitis

Subtypes of Hepatitis B

Acute Hepatitis B Infection 1 HBeAg-positive chronic hepatitis B virus infection 1 Hepatitis B virus-related acute-on-chronic liver failure 1

28 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hepatitis B

178 trials tracked for Hepatitis B: 105 in phase 3 or 4 and 19 with published results. The most-cited published study has 313 citations.

178Trials tracked
105Phase 3 & 4
0Recruiting
19With published results
Phase distribution
Phase 4 42 Phase 3 63 Phase 2 48 Phase 1 10 Other / NA 15
  1. Phase 4 Stopping TDF Treatment After Long Term Virologic Suppression in HBeAg-negative CHB Completed · 313 cited
  2. Phase 3 Study to Evaluate Efficacy and Safety of Switching From TDF to TAF in Adults With Chronic Hepatitis B Who Are Virologically Suppressed Completed · 139 cited
  3. Phase 4 Arresting Vertical Transmission of Hepatitis B Virus Completed · 55 cited
  4. Phase 3 B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B Completed · 36 cited
  5. Phase 3 Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B Completed · 25 cited
  6. Phase 3 Non-inferiority of GSK Biologicals' DTPw-HBV/Hib Compared to Two Formulations of GSK Biologicals' DTPw-HBV/Hib Completed · 18 cited
Show 44 more trials
  1. Phase 4 Hepatitis B Booster Study in Adolescence Completed · 16 cited
  2. Phase 4 A Randomized,Parallel-group Clinical Trial of Hepatitis B Vaccine With Different Dosages and Schedules in Healthy Adults Completed · 15 cited
  3. Phase 3 Immunogenicity and Safety Study of Proquad® and Infanrix® Hexa When Administered Concomitantly (V221-035) Completed · 13 cited
  4. Phase 4 A Study to Qualify an In-house Reference Standard Batch of Sci-B-Vac™ Completed · 12 cited
  5. Phase 4 Evaluation of Immunogenicity and Safety of a Booster Dose of Infanrix Hexa™ in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery Completed · 12 cited
  6. Phase 3 A Bridging Study: Comparing Two Lots of Sci-B-Vac™ and Engerix-B in Healthy Adults Completed · 12 cited
  7. Phase 4 Immunogenicity and Safety of GSK Biologicals' Infanrix Hexa in Infants Completed · 10 cited
  8. Phase 3 Safety and Immunogenicity of Recombinant Hepatitis B Vaccine Sci-B-Vac® Compared to Engerix-B® Completed · 10 cited
  9. Phase 3 Long-term Persistence of Hepatitis B and Pertussis Antibody Responses in Healthy 4 to 5 Year Old Children Previously Vaccinated With Vaxelis® or INFANRIX® Hexa (V419-012) Completed · 9 cited
  10. Phase 3 A Study to Assess the Immunogenicity and Safety of GSK Biologicals' Infanrix-IPV/Hib Vaccine Administered as a Three-dose Vaccination Course at 3, 4.5 and 6 Months of Age and a Booster Dose at 18 Months of Age in Healthy Infants in Russia Completed · 6 cited
  11. Phase 4 Vaccination Adjuved Against Hepatitis B in SNS Workers Typed as no Responders to Conventional Vaccines Completed · 4 cited
  12. Phase 3 Hepatitis B Challenge Dose in Adults (V232-059-10) Completed · 4 cited
  13. Phase 3 A Hepatitis B Vaccine Challenge Study After Previous Vaxelis® Vaccination (V419-013) Completed · 3 cited
  14. Phase 4 Study to Evaluate Antibody Persistence in Children Previously Vaccinated With Infanrix Hexa™ or Infanrix-IPV/Hib™ Completed
  15. Phase 4 Effect of Risk Factors Likely to Influence Immuno of Combined Hepatitis A & B Vacc vs Monovalent Hepatitis A & B Vacc Completed
  16. Phase 4 Telbivudine or Tenofovir Treatment in HBeAg-negative Chronic Hepatitis B Patients Based on the Roadmap Concept Completed
  17. Phase 4 A Study to Evaluate Persistence of Hepatitis B Antibodies, Immunogenicity and Safety of Engerix™-B Kinder Challenge Dose, in Adolescents Vaccinated With Four Doses of Infanrix™ Hexa During Infancy Completed
  18. Phase 4 B/F/TAF Switch Study for HIV-HBV Coinfection Completed
  19. Phase 4 Evaluation of Antibody Persistence and Immune Memory Against the Hepatitis B Antigen in Previously Vaccinated Children Completed
  20. Phase 4 Long-term Persistence Study in Healthy Adults Previously Vaccinated With Twinrix Adult Completed
  21. Phase 4 A Study in Korea of Entecavir Versus Lamivudine in Adults With Chronic Hepatitis B Infection Completed
  22. Phase 4 Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™ Completed
  23. Phase 4 Antibody Persistence & Immune Memory in Healthy Adults Previously Vaccinated With Twinrix Adult Completed
  24. Phase 4 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Engerix™-B in Adults With or Without Type 2 Diabetes Mellitus Completed
  25. Phase 4 Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination Completed
  26. Phase 4 LT F-up Study 16-20 Yrs After Vaccine Dose of Hepatitis B With/Without HBIg in Newborns to HBeAg+ Mothers Completed
  27. Phase 4 Efficacy & Safety of Tenofovir Disoproxil Fumarate (TDF) Plus Peginterferon α-2a (Peg-IFN) Versus TDF or Peg-IFN Monotherapy in Chronic Hepatitis B Completed
  28. Phase 4 Immune Response to Hepatitis B Vaccine Challenge Dose in Subjects Who Received a Primary Neonatal Hepatitis B Vaccine. Completed
  29. Phase 4 Safety and Immunogenicity of a Booster Dose of GlaxoSmithKline (GSK) Biologicals' Hepatitis B Vaccine Completed
  30. Phase 4 Immune Response of Healthy Subjects Who Received Neonatal Vaccination Course With Engerix™-B Vaccine. Completed
  31. Phase 4 Comparison of Three Hepatitis B Vaccination Regimens in HIV-Positive Youth Completed
  32. Phase 4 Evaluation of the Long-term Persistence of Immunity to Hepatitis B, in Adolescents Vaccinated in Infancy With Engerix™-B Kinder Completed
  33. Phase 4 Persistence of Immunity Against Hepatitis B in 12-13 Year Old Adolescents After Infant Hepatitis B Vaccination Completed
  34. Phase 4 Hepatitis B Antibody Persistence and Immune Response to Hepatitis B Vaccine Challenge in Previously Vaccinated Children Completed
  35. Phase 4 This Study Aims to Determine the Long-term Persistence of Antibodies Against Hepatitis B and to Evaluate the Immunogenicity and Safety of Hepatitis B Vaccine in Adolescents Vaccinated in Infancy With Infanrix™ Hexa Completed
  36. Phase 4 Adefovir Dipivoxil For The Treatment Of Chinese Compensated Chronic Hepatitis B(CHB)Patients Completed
  37. Phase 4 A Study to Evaluate Tenofovir Disoproxil Fumarate (DF) in Asian-American Adults With Chronic Hepatitis B Infection Completed
  38. Phase 4 Evaluating Blood Glucose Levels During Infusion With HepaGam B (HBIG) in Post-liver Transplant Patients Completed
  39. Phase 4 Adefovir Dipivoxil Tablets (10mg) In Chinese Subjects With HBe Antigen Negative Chronic Hepatitis B Completed
  40. Phase 4 Long Term Follow-Up Study 16-20 Years After Hepatitis B Vaccination in Newborns of Mothers Who Were Seropositive for Hepatitis B Envelope Antigen (HBeAg) & Hepatitis B Surface Antigen (HBsAg) Completed
  41. Phase 4 Study of Adefovir Dipivoxil for Korean Patients With Chronic Hepatitis B(CHB) Who Have Completed ADF 103814 Completed
  42. Phase 4 Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination Completed
  43. Phase 4 Adefovir Dipivoxil For The Treatment Of Patients With Chronic Hepatitis B Related Advanced Fibrosis Or Cirrhosis Completed
  44. Phase 4 Challenge Dose of Hepatitis B Vaccine in Subjects Who Previously Received Engerix™-B Vaccine Completed

Showing the 50 most-cited and recently-updated of 178 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Physical Medicine & Rehab Meta-analysis
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Jun 13, 2026
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models
Oncology Meta-analysis
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models Green tea compound shows potential for several digestive diseases
This meta-analysis of 63 preclinical studies involving 738 animals indicates that Epigallocatechin-3-gallate (EGCG) has a positive therapeut…
A review of animal studies suggests a green tea compound could help treat various cancers and digestive conditions.
Frontiers Jun 11, 2026
HLA-B*57:01-guided abacavir prescribing is the clearest preventive paradigm from HLA associations
Drug Pipeline Sys. Review
HLA-B*57:01-guided abacavir prescribing is the clearest preventive paradigm from HLA associations HLA genes shape HIV and hepatitis vaccine responses and drug reactions
This narrative review examines HLA polymorphisms in HIV, hepatitis C, and hepatitis B. The clearest preventive paradigm is HLA-B*57:01-guide…
A review finds that HLA genes strongly influence how people respond to HIV and hepatitis vaccines and how they react to certain medications.
Frontiers Jun 6, 2026
PEG-IFN plus novel agents may boost functional cure in chronic hepatitis B
Infectious Disease Sys. Review
PEG-IFN plus novel agents may boost functional cure in chronic hepatitis B Combination therapies may improve functional cure rates for chronic hepatitis B
This narrative review examines combining pegylated interferon-α with novel immunotherapies (antigen-reduction strategies, therapeutic vaccin…
A review suggests combining pegylated interferon with new immunotherapies could help achieve functional cure in chronic hepatitis B patients…
Frontiers Jun 6, 2026
One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds
Infectious Disease Meta-analysis
One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds 1 in 6 blood donors in Cameroon carries malaria parasite
A systematic review and meta-analysis of 18 studies (~12,500 donations) found a 16.6% pooled prevalence of Plasmodium spp. in Cameroonian bl…
A review of 18 studies finds 16.6% of blood donations in Cameroon contain Plasmodium, the malaria parasite.
May 30, 2026
Review of antiviral and immunotherapeutic strategies for chronic hepatitis B
Allergy & Immunology Sys. Review
Review of antiviral and immunotherapeutic strategies for chronic hepatitis B New antiviral strategies show promise for chronic hepatitis B infection
This narrative review synthesizes evidence on antiviral and immunotherapeutic strategies for chronic hepatitis B. The authors highlight func…
A review of new treatments suggests combination therapies may offer future value for managing chronic hepatitis B, cirrhosis, and liver canc…
Frontiers May 18, 2026
Meta-analysis identifies genetic variants linked to HBV susceptibility and HCC risk
Oncology Meta-analysis
Meta-analysis identifies genetic variants linked to HBV susceptibility and HCC risk Genetic Keys Unlock Why Some Get Liver Cancer From Hepatitis B
This meta-analysis of East Asian cohorts examined genetic variants associated with hepatitis B virus infection and hepatocellular carcinoma …
New research shows specific gene changes help explain why some people get Hepatitis B while others stay healthy.
May 2, 2026
Pegylated interferon alpha associated with HBsAg clearance in postpartum women with chronic HBV infection
Infectious Disease Cohort
Pegylated interferon alpha associated with HBsAg clearance in postpartum women with chronic HBV infection New treatment clears hepatitis B in 3 out of 10 women after childbirth
This prospective cohort study evaluated 263 postpartum women with chronic hepatitis B virus infection and baseline HBsAg levels ≤3000 IU/mL.
A new treatment clears hepatitis B markers in nearly 30% of women after childbirth, offering fresh hope for a functional cure during a uniqu…
Frontiers Apr 29, 2026
Absence of antiviral therapy and multiple chemotherapeutic agents increase HBV reactivation risk after TACE
Oncology Cohort
Absence of antiviral therapy and multiple chemotherapeutic agents increase HBV reactivation risk after TACE No Antiviral Meds Raise Liver Cancer Risks After Chemo
This retrospective cohort study of 168 HBsAg-positive HCC patients undergoing TACE found that absence of prophylactic antiviral therapy (OR …
Many liver cancer patients with hepatitis B face avoidable risks during chemo—because they’re not getting a simple antiviral pill most alrea…
Frontiers Apr 28, 2026
Narrative review on ICIs in patients with viral infections and solid tumors
Allergy & Immunology Sys. Review
Narrative review on ICIs in patients with viral infections and solid tumors Cancer Immunotherapy Works Differently in Viral Infections
This narrative review synthesizes evidence on immune checkpoint inhibitors in patients with viral infections and solid tumors.
Cancer immunotherapy can still work—and sometimes even control viruses like hepatitis or HIV—but doctors must watch for dangerous flare-ups.
Frontiers Apr 27, 2026
HBV-positive status linked to higher surgical conversion in unresectable HCC receiving triple therapy
Allergy & Immunology Cohort
HBV-positive status linked to higher surgical conversion in unresectable HCC receiving triple therapy HBV-positive linked to better outcomes in liver cancer triple therapy
This single-center retrospective cohort study evaluated triple therapy with TACE, lenvatinib, and PD-1 inhibitors in 190 patients with initi…
In unresectable liver cancer, triple therapy with TACE, lenvatinib, and PD-1 inhibitors worked better in HBV-positive patients, a small retr…
Frontiers Apr 24, 2026
Review of liver disease immunomodulation strategies notes precision over broad suppression
Neurology Sys. Review
Review of liver disease immunomodulation strategies notes precision over broad suppression Your Liver's Immune Cells Play Both Hero and Villain at Once
This narrative review examines immunomodulation approaches for liver diseases, including acute liver injury, HBV infection, MASLD/MASH, fibr…
Liver immune cells can both damage and repair your organ at the same time, a discovery that could unlock new precision treatments for hepati…
Frontiers Apr 18, 2026

Research across Hepatitis

Related studies from across the Hepatitis family.

Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance
Allergy & Immunology Sys. Review
Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance Immune defects in hepatitis C may last after the virus is gone
This narrative review examines immune mechanisms in patients with chronic hepatitis C virus infection. The authors describe how prolonged an…
A review explains how chronic hepatitis C causes lasting immune changes that persist even after the virus is cleared, suggesting new treatme…
Frontiers Jun 1, 2026
Systematic review and meta-analysis of biopsy-guided versus clinically guided withdrawal in autoimmune hepatitis
Gastroenterology Meta-analysis
Systematic review and meta-analysis of biopsy-guided versus clinically guided withdrawal in autoimmune hepatitis Biopsy-guided withdrawal shows no benefit over clinical guidance for autoimmune hepatitis
This systematic review and meta-analysis evaluated relapse rates after treatment withdrawal in patients with autoimmune hepatitis.
A meta-analysis of 518 patients found that biopsy-guided withdrawal did not lower relapse rates compared to clinically guided withdrawal in …
May 1, 2026
HEV 239 vaccine induces durable humoral and cellular immunity in Bangladeshi women
Gastroenterology RCT
HEV 239 vaccine induces durable humoral and cellular immunity in Bangladeshi women Hepatitis E vaccine shows durable immunity in women
This longitudinal cohort study in 1480 women aged 16-39 years in Bangladesh found that HEV 239 (Hecolin) vaccination led to significantly hi…
A hepatitis E vaccine kept women protected for up to 3 years, with stronger immune memory than a comparison group.
May 1, 2026
Hepatic steatosis prevalence and impact in autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis
Oncology Meta-analysis
Hepatic steatosis prevalence and impact in autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis Fatty liver makes autoimmune hepatitis and PBC worse, but not PSC
This systematic review and meta-analysis of 19,898 patients with autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing c…
A large review found fatty liver is common in autoimmune liver diseases and makes outcomes worse for some patients, but not others.
Apr 28, 2026
Integrative review of Epimedium flavonoids in hepatitis and cirrhosis shows preclinical promise but lacks clinical validation
Gastroenterology Sys. Review
Integrative review of Epimedium flavonoids in hepatitis and cirrhosis shows preclinical promise but lacks clinical validation Ancient Herb Shows New Promise for Liver Scarring and Hepatitis
This integrative review synthesizes data from 33 high-impact studies regarding Epimedium species and its bioactive flavonoids, icariin and i…
This research suggests a traditional herb may offer a new way to protect the liver, but more work is needed to prove it’s safe and effective…
Frontiers Apr 22, 2026
Meta-analysis of 55 studies assesses HCV prevalence trends across Eastern Mediterranean Region populations
Gastroenterology Meta-analysis
Meta-analysis of 55 studies assesses HCV prevalence trends across Eastern Mediterranean Region populations HCV Rates Drop in High-Risk Groups After 2015
This umbrella review synthesizes data from 55 meta-analyses evaluating hepatitis C virus (HCV) prevalence in the Eastern Mediterranean Regio…
Imagine walking into a doctor's office and feeling a knot of worry in your stomach.
Apr 22, 2026
Randomized trial shows ribavirin increases mutational load and specific transition signatures in HCV
Infectious Disease
Randomized trial shows ribavirin increases mutational load and specific transition signatures in HCV Ribavirin linked to increased hepatitis C virus mutations in trial
This secondary analysis of a randomized trial in HCV-infected participants found ribavirin exposure significantly increased total mutational…
Ribavirin treatment linked to increased hepatitis C virus mutations in a trial, though real-world impact on cure rates remains unclear.
medRxiv Apr 19, 2026
Narrative review synthesizes evidence on NAFLD, NASH, and viral hepatitis management without reported trial data
Allergy & Immunology Sys. Review
Narrative review synthesizes evidence on NAFLD, NASH, and viral hepatitis management without reported trial data Your Liver Has an Immune Army — and It Can Turn Against You
This narrative review addresses management considerations for nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH),…
Your liver's own immune cells can turn on itself to cause permanent scarring, but scientists are now mapping these cells to stop the damage …
Frontiers Apr 18, 2026
Infliximab in IVIG-resistant Kawasaki disease with cholestatic hepatitis: case report
Pediatrics RCT
Infliximab in IVIG-resistant Kawasaki disease with cholestatic hepatitis: case report Can a new drug stop heart damage in Kawasaki disease when standard treatments fail?
A case report describes a 2-year-old Han Chinese male with IVIG-resistant Kawasaki disease and cholestatic hepatitis treated with infliximab…
In a two-year-old boy with Kawasaki disease, the drug infliximab quickly stopped his fever and liver trouble, yet his heart artery damage ke…
Frontiers Apr 16, 2026
Meta-analysis of 9 studies estimates HCV seroprevalence of 3.63% among African refugees and displaced persons
Gastroenterology Meta-analysis
Meta-analysis of 9 studies estimates HCV seroprevalence of 3.63% among African refugees and displaced persons Hidden Virus Threats Among Displaced People
This systematic review and random-effects meta-analysis of 9 studies estimated hepatitis C virus (HCV) seroprevalence among refugees, asylum…
A new look at data shows hepatitis C is very common among refugees and displaced people in Africa, where they often face huge barriers to ge…
Apr 16, 2026
Hepatitis E vaccine linked to elevated spontaneous abortion risk when given 31-60 days before pregnancy
Gastroenterology RCT
Hepatitis E vaccine linked to elevated spontaneous abortion risk when given 31-60 days before pregnancy A Vaccine's Hidden Risk Window for Early Pregnancy Loss
An RCT in women vaccinated during or shortly before pregnancy found an elevated risk of spontaneous abortion (Relative Risk 4.3) in HEV239 r…
A Hepatitis E vaccine given one to two months before pregnancy is linked to a higher risk of miscarriage, forcing doctors to rethink timing …
Apr 13, 2026
Machine learning models predict SVR in comorbid HCV patients treated with sofosbuvir, daclatasvir, and ribavirin in Pakistan
Primary Care & Family Medicine Cohort
Machine learning models predict SVR in comorbid HCV patients treated with sofosbuvir, daclatasvir, and ribavirin in Pakistan Can a computer predict your hepatitis C cure?
This retrospective cohort study evaluated machine learning prediction models in 221 comorbid HCV patients in Pakistan.
A new computer tool can spot which hepatitis C patients are likely to fail treatment before they even start taking pills.
Frontiers Apr 13, 2026

Questions about Hepatitis B

Can hepatic steatosis make fibrosis staging less accurate in chronic hepatitis B?

Yes, hepatic steatosis can significantly reduce the accuracy of noninvasive fibrosis staging tools like APRI and FIB-4 in chronic hepatitis B patients.

Full answer →
What are the side effects of pegylated interferon-alpha for chronic hepatitis B?

Pegylated interferon-alpha for chronic hepatitis B commonly causes flu-like symptoms, bone marrow suppression, depression, and autoimmune reactions, often leading to dose adjustments.

Full answer →
Can receiving a liver transplant from a donor with Hepatitis B Virus cause infection?

Yes, a liver transplant from a donor with HBV can transmit the virus, but the risk is low (about 4%) and can be reduced with antiviral drugs and vaccination.

Full answer →
Does having Hepatitis B Virus Infection make my liver surgery more likely to fail?

Yes, active HBV infection can increase the risk of liver surgery failure, mainly due to higher chances of viral reactivation and liver damage, but antiviral therapy significantly lowers this risk.

Full answer →
Are immune checkpoint inhibitors safe for patients with Hepatitis B Virus Infection and solid tumors?

Immune checkpoint inhibitors appear safe for HBV patients with solid tumors when viral load is suppressed, but reactivation risk exists, especially during immunosuppression for immune-related adverse events.

Full answer →
How does Hepatitis B infection prevalence differ among US adults based on their race and origin?

NHANES data show that among US adults, past or present Hepatitis B infection is more common in Black adults and those born outside the US compared to White adults or those born in the US.

Full answer →
See all 6 questions about Hepatitis B →

All Hepatitis B Articles