Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Insomnia

Insomnia

Part of Sleep Disorders, Intrinsic

Subtypes of Insomnia

Clinical insomnia 1

34 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Insomnia

199 trials tracked for Insomnia: 61 in phase 3 or 4 and 15 with published results. The most-cited published study has 238 citations.

199Trials tracked
61Phase 3 & 4
0Recruiting
15With published results
Phase distribution
Phase 4 31 Phase 3 30 Phase 2 20 Phase 1 9 Other / NA 109
  1. Phase 3 Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects With Insomnia Disorder Completed · 238 cited
  2. Phase 3 Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep Completed · 238 cited
  3. Phase 4 Reducing Suicidal Ideation Through Insomnia Treatment Completed · 152 cited
  4. Phase 3 Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia Completed · 107 cited
  5. Phase 3 Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep Completed · 97 cited
  6. Phase 3 The Healthy Patterns Sleep Study Completed · 71 cited
Show 44 more trials
  1. Phase 4 Suvorexant and Trauma Related Insomnia Completed · 26 cited
  2. Phase 3 Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis Completed · 22 cited
  3. Phase 4 Efficacy of Suvorexant in the Treatment of Hot Flash-associated Insomnia Completed · 21 cited
  4. Phase 3 Long-term Study of Lemborexant in Insomnia Disorder (SUNRISE 2) Completed · 17 cited
  5. Phase 3 Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1) Completed · 14 cited
  6. Phase 4 Treatment of Insomnia in Migraineurs Completed · 13 cited
  7. Phase 4 Study to Compare the Awakening Threshold Effects of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs Completed · 10 cited
  8. Phase 4 Suvorexant and Sleep/Delirium in ICU Patients Completed · 9 cited
  9. Phase 4 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Completed · 5 cited
  10. Phase 4 The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy Completed
  11. Phase 4 To Compare the Effectiveness of Suvorexant vs Placebo on Sleep Pressure in Hypertensives With Insomnia Completed
  12. Phase 4 Eszopiclone in the Treatment of Insomnia and Fibromyalgia Completed
  13. Phase 4 Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder Completed
  14. Phase 4 Efficacy of Suvorexant to Treat Insomnia Related to Bipolar Disorder Completed
  15. Phase 4 Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Completed
  16. Phase 4 Safety and Efficacy of Chronic Hypnotic Use 2 Completed
  17. Phase 4 A Pilot Study of Suvorexant for Insomnia in Parkinson Disease Completed
  18. Phase 4 A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia Completed
  19. Phase 4 CBT-I or Zolpidem/Trazodone for Insomnia Completed
  20. Phase 4 A Study to Find Out if Daridorexant is Safe and Efficacious in Patients With Insomnia and Comorbid Nocturia Completed
  21. Phase 4 Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia Completed
  22. Phase 4 Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia Completed
  23. Phase 4 A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia Completed
  24. Phase 4 Treatment of Insomnia and Glucose Metabolism Completed
  25. Phase 4 Efficacy and Safety of Temazepam in HIV Seropositive Patients With Insomnia Completed
  26. Phase 4 Long Term Treatment With Zolpidem: Nightly and Intermittent Dosing Completed
  27. Phase 4 The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia Completed
  28. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  29. Phase 4 Mechanisms of Sleep Latency and Health: The Effect of a Melatonin Receptor Agonist in Inflammation and Insulin Resistance Completed
  30. Phase 4 The Treatment of Insomnia in Patients With HIV Disease Completed
  31. Phase 4 Facilitation of Zolpidem (≥10 mg) Discontinuation Through Use of Ramelteon in Subjects With Chronic Insomnia Completed
  32. Phase 4 Eszopiclone Treatment & Cortisol Responsivity Completed
  33. Phase 4 Study of the Insomnia in Patients With Low Back Pain Completed
  34. Phase 3 Two Contrasting Interventions for Sleep Management Completed
  35. Phase 3 Treatment of Insomnia in Elderly Sleep Apnea Patients With Ramelteon (TAK 375) Completed
  36. Phase 3 A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia Completed
  37. Phase 3 Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study B (MK-4305-029) Completed
  38. Phase 3 Almorexant (ACT 078573) in Adult Subjects With Chronic Primary Insomnia Completed
  39. Phase 3 Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study A (MK-4305-028) Completed
  40. Phase 3 VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia Completed
  41. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  42. Phase 3 A Six Week, Double-Blind Randomized, Efficacy and Safety, Sleep Lab Trial With Esmirtazapine (Org 50081) (P05707) Completed
  43. Phase 3 Efficacy and Safety of Circadin® 2 mg in the Treatment of Primary Insomnia Patients Completed
  44. Phase 3 A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150) Completed

Showing the 50 most-cited and recently-updated of 199 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia
Neurology Meta-analysis
Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia Tuina combination therapies beat oral medication for insomnia in this exploratory review
This systematic review and network meta-analysis evaluated Tuina-based combination therapies against oral medication in 2,663 subjects with …
Combining Tuina with breath guiding, music, or foot baths worked better than oral medication for insomnia in this review of 2,663 patients.
Frontiers May 28, 2026
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Drug Pipeline Sys. Review
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Frontiers May 25, 2026
Meta-analysis finds probiotics modestly improve sleep quality with low certainty
Neurology Meta-analysis
Meta-analysis finds probiotics modestly improve sleep quality with low certainty Probiotics may modestly improve sleep quality, review finds
This meta-analysis of 39 trials (4094 participants) found that probiotic supplementation modestly improved global sleep quality (MD -0.71 on…
A meta-analysis of 39 trials found probiotics slightly improved sleep quality and daytime function, but effects were small and evidence unce…
Frontiers May 23, 2026
Meta-analysis of 2,579 participants identifies neural dysfunction patterns in insomnia disorder
Radiology & Imaging Meta-analysis
Meta-analysis of 2,579 participants identifies neural dysfunction patterns in insomnia disorder Insomnia changes brain circuits and gene activity in specific ways
This meta-analysis of 2,579 participants, including 1,305 with insomnia disorder and 1,274 healthy controls, synthesizes neural dysfunction …
A massive review of brain scans shows insomnia changes specific brain circuits and gene activity linked to energy and focus
May 15, 2026
Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
Neurology Sys. Review
Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders New research explains how one gene causes many brain disorders
This narrative review examines the association between NRXN1 genetic variations and a spectrum of neuropsychiatric disorders including schiz…
A single gene variation may explain why schizophrenia and autism often appear together, offering new hope for understanding these complex br…
Frontiers May 13, 2026
Pragmatic approach addresses post-stroke insomnia through objective sleep phenotyping and coordinated management of dominant drivers
Neurology Sys. Review
Pragmatic approach addresses post-stroke insomnia through objective sleep phenotyping and coordinated management of dominant drivers Stroke survivors sleep better with this new approach
This narrative review outlines a pragmatic, mechanism-informed strategy for managing post-stroke insomnia. It emphasizes objective sleep phe…
Stroke survivors with insomnia may sleep better when doctors match treatments to the specific cause of their sleep problem.
Frontiers May 4, 2026
Perioperative taVNS Reduces Pain and Insomnia After Glaucoma Surgery
Ophthalmology RCT
Perioperative taVNS Reduces Pain and Insomnia After Glaucoma Surgery Vagus nerve stimulation lowers pain after glaucoma surgery
This randomized trial of 94 patients undergoing glaucoma surgery found that perioperative transcutaneous auricular vagus nerve stimulation (…
A trial found that vagus nerve stimulation reduced pain and improved sleep for patients having glaucoma surgery under general anesthesia.
Apr 29, 2026
Meta-analysis shows benzodiazepine receptor PAMs improve sleep but increase long-term COPD risks in patients with insomnia
Drug Pipeline Meta-analysis
Meta-analysis shows benzodiazepine receptor PAMs improve sleep but increase long-term COPD risks in patients with insomnia New drug improves sleep but raises long-term risks for COPD patients
This meta-analysis evaluates benzodiazepine receptor positive allosteric modulators (PAMs) in COPD patients with comorbid insomnia.
A new drug helps COPD patients sleep better but increases long-term risks like hospital visits and death.
Frontiers Apr 29, 2026
Mixed-methods review highlights delays and pharmacological overreliance in chronic insomnia and GAD management
Primary Care & Family Medicine Sys. Review
Mixed-methods review highlights delays and pharmacological overreliance in chronic insomnia and GAD management Why millions wait years before treating sleep and anxiety together
This mixed-methods review synthesizes qualitative data from 29 semi-structured online interviews conducted in the United States involving pa…
New research reveals why millions wait years before getting proper help for sleep and anxiety problems in the United States.
Frontiers Apr 25, 2026
Protocol for Exploratory RCT Testing CBT-I Plus Ayurvedic Therapies for Insomnia in Perimenopausal Women
Drug Pipeline RCT
Protocol for Exploratory RCT Testing CBT-I Plus Ayurvedic Therapies for Insomnia in Perimenopausal Women Sleep better with ancient oil tricks
This exploratory randomized controlled trial protocol outlines a study involving 62 perimenopausal women aged 45–55 years with insomnia.
Many women in their 40s and 50s struggle with sleep right now.
Frontiers Apr 24, 2026
Daridorexant 25 or 50 mg improved sleep parameters in patients with comorbid insomnia disorder and untreated mild obstructive sleep apnoea
Drug Pipeline RCT
Daridorexant 25 or 50 mg improved sleep parameters in patients with comorbid insomnia disorder and untreated mild obstructive sleep apnoea New Hope for Sleep Without Risking Breathing
This post hoc subgroup analysis of a Phase 3 randomized clinical trial evaluated daridorexant in patients with comorbid insomnia disorder an…
You lie in bed for hours, wide awake. You’re exhausted—but your mind won’t shut off.
Apr 24, 2026
Chronic Insomnia in Hospitalized Adults: Associated Conditions and Metabolic Abnormalities
Psychiatry Cohort
Chronic Insomnia in Hospitalized Adults: Associated Conditions and Metabolic Abnormalities Elderly women with insomnia often have heart disease, infections, and metabolic issues
This retrospective observational study evaluated 871 hospitalized adults aged 18 to 100 years with chronic insomnia at a single center in Ch…
Hospitalized older women with insomnia frequently face infections, heart disease, and blood sugar problems, a single-center study finds.
Frontiers Apr 22, 2026

Questions about Insomnia

Can breathwork reduce stress and anxiety in paramedic students with insomnia?

Yes, a 12-week RCT found that slow diaphragmatic breathwork significantly reduced stress, anxiety, and insomnia in paramedic students.

Full answer →