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Home › Conditions › Liver disease

Liver disease

Subtypes of Liver disease

Hepatic impairment 2 Autosomal dominant polycystic liver disease 1 Cholestatic liver injury 1 Genetic metabolic liver diseases 1 Hepatopathy 1 Non-septic acute liver injury 1

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Liver disease

50 trials tracked for Liver disease: 13 in phase 3 or 4 and 6 with published results. The most-cited published study has 108 citations.

50Trials tracked
13Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 7 Phase 3 6 Phase 2 10 Phase 1 5 Other / NA 22
  1. Phase 4 Monitoring SOF/VEL in Treatment Naïve, HCV Participants With Active Infection Completed · 108 cited
  2. Phase 3 Correlation and Comparison of the HepQuant® Disease Severity Index (DSI) With Hepatic Venous Pressure Gradient (HVPG) Completed · 78 cited
  3. Phase 4 Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension Completed · 77 cited
  4. Phase 4 Detection of Liver Fibrosis With Magnetic Resonance Imaging (MRI) Completed · 76 cited
  5. Phase 3 Safety and Efficacy Study of Lusutrombopag for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Elective Invasive Procedures Completed · 14 cited
  6. Phase 4 deLIVER: Direct Acting Antiviral Effects on the Liver Completed · 2 cited
Show 44 more trials
  1. Phase 4 Prospective Validation of a Plasma Transfusion Dosing Algorithm in Patients With Chronic Liver Disease Completed
  2. Phase 4 Mycophenolate Mofetil Immunosuppression Without/With Reduced Dose Calcineurin Inhibitor Long After Liver Transplantation Completed
  3. Phase 4 Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed
  4. Phase 3 BreathID 13C-Methacetin Breath Test for Detecting Cirrhosis Completed
  5. Phase 3 Octreotide in Severe Polycystic Liver Disease Completed
  6. Phase 3 Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH Completed
  7. Phase 3 Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS) Completed
  8. Phase 2 Proof of Concept Study Concerning Efficacy of P03277 MR Imaging in HCC Diagnosis Completed
  9. Phase 2 Alisporivir With RBV in Chronic Hepatitis C Genotype 2 and 3 Participants for Whom Interferon is Not an Option Completed
  10. Phase 2 Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV) Completed
  11. Phase 2 Autologous Dendritic Cell Vaccine for Treatment of Patients With Chronic HCV-Infection Completed
  12. Phase 2 Immune System Suppression With Alemtuzumab and Tacrolimus in Liver Transplantation Patients Completed
  13. Phase 2 A Phase I/II Safety and Tolerability Dose Escalation Study of Autologous Stem Cells to Patients With Liver Insufficiency Completed
  14. Phase 2 Phase 2, Pharmacokinetics Study of Eltrombopag in Japanese Thrombocytopenic Subjects With Chronic Liver Disease Completed
  15. Phase 2 A Clinical Trial to Evaluate the Efficacy and Safety of Two Aramchol Doses Versus Placebo in Patients With NASH Completed
  16. Phase 2 Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda Interferon Completed
  17. Phase 2 Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016) Completed
  18. Phase 1 PK and PD Study of IDN-6556 in Subjects With Hepatic Impairment and Matched Healthy Volunteers Completed
  19. Phase 1 A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants. Completed
  20. Phase 1 A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease Completed
  21. Phase 1 A Study of Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems Completed
  22. Phase 1 Influence of Mild and Moderate Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of Various Doses of Afatinib Completed
  23. N/A Normal Liver Stiffness by MR Elastography Completed
  24. N/A The SHUNT-V Study for Varices Completed
  25. N/A Determination of Liver Stiffness in Chronic Liver Disease Patients by Acoustic Radiation Force Imaging (ARFI) Ultrasound Completed
  26. N/A Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD) Completed
  27. N/A Sonoelastography: Ultrasound Method to Measure Liver Fibrosis Completed
  28. N/A Breath Analysis Based Disease Biomarkers Completed
  29. N/A Biobehavioral Pathways Underlying Alcohol Use and Health Completed
  30. N/A Beyond Confounders: Addressing Source of Measurement Variability and Error in Shear Wave Elastography Completed
  31. N/A The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient Completed
  32. N/A The Patient-Reported Outcomes Project of HCV-TARGET Completed
  33. N/A Comparison of the Hemostatic Patch to Fibrin Sealant (TachoSil®) in Subjects Undergoing Hepatic Surgery Completed
  34. N/A Benign Liver Optimal Core Study (Tissue Acquisition Comparison in Benign Liver Disease) Completed
  35. N/A Michigan Alcohol Improvement Network- Alcohol Reduction and Treatment Trial Completed
  36. N/A GATT-Patch Versus TachoSil in Liver Surgery Completed
  37. N/A Prediction Value of the BreathID 13C-Methacetin Breath Test for Hepatic Decompensation Completed
  38. N/A Controlled Attenuation Parameter (CAP) in Liver Allografts Completed
  39. N/A 19 Versus 22-Gauge Needle for EUS-LB Completed
  40. N/A The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. Completed
  41. N/A NASH Fitness Intervention in Thrombosis Trial (NASHFit) Completed
  42. N/A A Study to Evaluate Liver Stiffness With Shear Wave Elastography Completed
  43. N/A A2ALL-Patients Safety System Improvements in Living Donor Liver Transplantation Completed
  44. N/A Hepatic Effects of Gastric Bypass Surgery Completed

Showing the 50 most-cited and recently-updated of 50 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions
Drug Pipeline Meta-analysis
Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions Ancient Herbs May Help Modern Health
This systematic review synthesizes data on Rhaponticum species, covering 24 documented species worldwide and their applications for conditio…
Imagine walking through a garden filled with wildflowers.
Frontiers Apr 24, 2026
Narrative review of bile-based traditional Chinese medicines for liver diseases
Drug Pipeline Sys. Review
Narrative review of bile-based traditional Chinese medicines for liver diseases Bile-Based Medicine May Heal Your Liver, But It Can Also Hurt It
This narrative review examines bile-based traditional Chinese medicines used in the management of liver diseases.
Traditional medicines made from animal bile can help treat liver disease, but they contain a complex mix of helpful and potentially harmful …
Frontiers Apr 24, 2026
Preclinical deep learning framework shows improved dose prediction for unseen cancer sites
Radiology & Imaging
Preclinical deep learning framework shows improved dose prediction for unseen cancer sites A Heavy Burden on Doctors
This is a preclinical development study of a deep learning framework for radiotherapy dose prediction.
A new AI tool can plan radiation doses for many different cancers at once.
medRxiv Apr 24, 2026
Preclinical analysis of gnomAD and ClinVar databases on ADPLD variant frequencies
Nephrology
Preclinical analysis of gnomAD and ClinVar databases on ADPLD variant frequencies Genetic variants linked to polycystic liver disease found in many people
This other publication is a preclinical analysis of gnomAD and ClinVar databases for predicted pathogenic variants in ADPLD genes.
Analysis of large genetic databases shows predicted pathogenic variants for polycystic liver disease occur in about 1 in 95 people, with hig…
medRxiv Apr 23, 2026
Retrospective analysis of 326 infants with infantile cholestasis reveals etiological spectrum
Pediatrics Cohort
Retrospective analysis of 326 infants with infantile cholestasis reveals etiological spectrum Simple Blood Marker Could Save Babies from Surgery Delays
This retrospective cohort study evaluated 326 infants diagnosed with infantile cholestasis at the Children's Hospital Affiliated to Shandong…
A new blood test might help doctors find the right cause of baby liver disease faster.
Frontiers Apr 22, 2026
Review of liver disease immunomodulation strategies notes precision over broad suppression
Neurology Sys. Review
Review of liver disease immunomodulation strategies notes precision over broad suppression Your Liver's Immune Cells Play Both Hero and Villain at Once
This narrative review examines immunomodulation approaches for liver diseases, including acute liver injury, HBV infection, MASLD/MASH, fibr…
Liver immune cells can both damage and repair your organ at the same time, a discovery that could unlock new precision treatments for hepati…
Frontiers Apr 18, 2026
Hematocrit–albumin gap linked to sepsis risk in ICU adults in retrospective analysis
Rheumatology Cohort
Hematocrit–albumin gap linked to sepsis risk in ICU adults in retrospective analysis Does a simple blood number predict sepsis risk in ICU patients?
A retrospective cross-sectional analysis of 19,134 adults with first ICU admissions found that a higher hematocrit–albumin gap (HAG) was ass…
A simple blood number called the hematocrit–albumin gap predicts sepsis risk in ICU patients, with higher levels increasing infection odds b…
Frontiers Apr 18, 2026
MAIT cell frequency decreased in sepsis-related liver injury, with altered phenotype and function in murine models
Infectious Disease Cohort
MAIT cell frequency decreased in sepsis-related liver injury, with altered phenotype and function in murine models Liver cells get help from immune defenders during sepsis
This observational cohort study in patients with sepsis-related liver injury (SRLI) and murine models found significantly decreased peripher…
During sepsis, immune defenders actually protect the liver instead of causing damage, offering new hope for patients losing liver function.
Frontiers Apr 17, 2026
Narrative review examines TCM herbal extracts and formulas regarding cholestatic liver injury
Gastroenterology Sys. Review
Narrative review examines TCM herbal extracts and formulas regarding cholestatic liver injury Your Gut Holds The Key To Liver Health
This narrative review synthesizes existing literature on the association between Traditional Chinese Medicine (TCM) herbal extracts and form…
Unbalanced gut bacteria disrupt bile flow and trigger liver inflammation, but Traditional Chinese Medicine strategies may restore balance an…
Frontiers Apr 16, 2026
Retrospective cohort study links prior antibiotic exposure and Gram-negative infections to high MDR rates in adult patients with chronic liver disease
Infectious Disease Cohort
Retrospective cohort study links prior antibiotic exposure and Gram-negative infections to high MDR rates in adult patients with chronic liver disease High antibiotic resistance found in infections among chronic liver disease patients in India
This retrospective observational cohort study evaluated 317 adult patients with chronic liver disease and culture-positive bacterial infecti…
In India, nearly 80% of E. coli and K. pneumoniae infections in chronic liver disease patients are resistant to multiple antibiotics.
Frontiers Apr 16, 2026
Disability benefit take-up varied by cause of death and geography in England and Wales
Palliative Care Cohort
Disability benefit take-up varied by cause of death and geography in England and Wales Millions Miss Out on Money Before Death
This retrospective cohort study examined 1,049,493 decedents aged 16 or older in England and Wales with chronic illnesses.
In England and Wales, one out of three people dying from expected causes like cancer or heart disease never receive the financial benefits t…
medRxiv Apr 14, 2026
Review explores gut-liver axis role in animal diseases, suggests dietary and probiotic strategies
Neurology Sys. Review
Review explores gut-liver axis role in animal diseases, suggests dietary and probiotic strategies Could your gut health affect your liver? Animal research explores the connection
A systematic review summarizes evidence on the gut-liver axis in ruminants, pigs, and poultry.
A leaky gut can send trouble signals to the liver, disrupting metabolism and potentially causing inflammation in animals like cows, pigs, an…
Frontiers Apr 2, 2026

Questions about Liver disease

Does mitochondrial dysfunction play a role in liver injury?

Yes, mitochondrial dysfunction is a key driver of liver injury, contributing to cell death and disease progression in conditions like fatty liver and alcohol-associated liver disease.

Full answer →
Does activating the aryl hydrocarbon receptor cause liver damage?

Activating the aryl hydrocarbon receptor can cause liver damage or protect it depending on the specific signals and context, acting as a double-edged sword in liver health.

Full answer →