Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Periodontitis

Periodontitis

Part of Periodontal Disease

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Periodontitis

29 trials tracked for Periodontitis: 9 in phase 3 or 4 and 1 with published results. The most-cited published study has 161 citations.

29Trials tracked
9Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 5 Phase 3 4 Phase 2 5 Other / NA 15
  1. Phase 4 Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis Completed · 161 cited
  2. Phase 4 Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis Completed
  3. Phase 4 Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis Completed
  4. Phase 4 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed
  5. Phase 4 Long-term Safety of Minocycline in Patients With Gum Disease Completed
  6. Phase 3 Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes Completed
Show 23 more trials
  1. Phase 3 Antibiotic Study for Dental Implants Completed
  2. Phase 3 Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population Completed
  3. Phase 3 Periodontal Infection and Endothelial Dysfunction Completed
  4. Phase 2 The Effects of DHA on Periodontitis Completed
  5. Phase 2 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers Completed
  6. Phase 2 Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status. Completed
  7. Phase 2 Impact of Periodontal Therapy on Patients With Diabetes Completed
  8. Phase 2 Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP Completed
  9. N/A Periodontal Disease Prevention Study Completed
  10. N/A Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects Completed
  11. N/A Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy Completed
  12. N/A SmartMouth Advanced Clinical Formula Clinical Research Design Protocol Completed
  13. N/A Changes in the Risk Factors of Coronary Heart Disease Observed After Scaling and Root Planing Completed
  14. N/A Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis Completed
  15. N/A Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome Completed
  16. N/A Combined Use of Er:YAG and Nd:YAG Laser Completed
  17. N/A Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis Completed
  18. N/A Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans Completed
  19. N/A Emdogain Minimally Invasive Surgical Technique Completed
  20. N/A Impact of Debridement Invasiveness on Attachment Gain After Antiinfective Periodontal Therapy Completed
  21. N/A Role of Infected Blood Dendritic Cells in Heart Disease Risk Completed
  22. N/A Effectiveness of Three Different Mouthrinses in Dental Plaque Control and Early Wound Healing Completed
  23. N/A Macrophage Markers in Periodontal and Peri-implant Health and Disease Completed

Showing the 29 most-cited and recently-updated of 29 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
High Infection Rates in Type 2 Diabetes: Periodontitis Prevalence at 33.6%
Diabetes & Endocrinology Meta-analysis
High Infection Rates in Type 2 Diabetes: Periodontitis Prevalence at 33.6% Are Infections Hitting People with Type 2 Diabetes Harder Than We Thought?
This meta-analysis found severe periodontitis prevalence at 33.6% (95% CI: 23.7-44.2) and lower respiratory tract infection incidence at 140…
People with type 2 diabetes face higher rates of severe gum disease and frequent lung infections, making infection prevention a critical par…
Mar 27, 2026

Questions about Periodontitis

Is there a connection between periodontitis and systemic health disorders?

Yes, periodontitis is linked to several systemic disorders like cardiovascular disease, diabetes, and liver disease, but direct causation is not proven.

Full answer →
Do oral bacteria change as periodontitis gets worse in Korean adults?

Yes, oral bacteria change as periodontitis worsens in Korean adults, with higher diversity and specific bacterial shifts seen in advanced stages.

Full answer →
What is the link between periodontitis and non-alcoholic fatty liver disease?

Research is mixed: some reviews suggest periodontitis may worsen NAFLD through the oral-gut-liver axis, but a large meta-analysis found no clear association.

Full answer →
Can having periodontitis increase my risk for liver disease or cancer?

Yes, periodontitis may increase the risk of liver disease and liver cancer, likely through systemic inflammation and bacterial spread, but direct causation is not proven.

Full answer →
How does oxidative stress affect the body in people with periodontitis?

In periodontitis, oxidative stress amplifies inflammation, damages tissues, and drives bone loss by overwhelming the body's antioxidant defenses.

Full answer →
Does subgingival chemical irrigation help treat periodontitis better than standard care?

No, subgingival chemical irrigation does not provide additional benefit over standard non-surgical periodontal treatment alone for periodontitis.

Full answer →
See all 6 questions about Periodontitis →