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Home › Conditions › Pneumonia

Pneumonia

Subtypes of Pneumonia

Community-Acquired Pneumonia 13 Mycoplasma pneumoniae pneumonia 10 Klebsiella pneumoniae infection 5 Mycoplasma pneumoniae infection 4 Bacterial pneumonia 3 Ventilator-associated pneumonia 3 Carbapenem-Resistant Klebsiella pneumoniae Infection 2 Influenza A virus pneumonia 2 Multidrug-resistant Klebsiella pneumoniae infection 2 Carbapenem-resistant Hypervirulent Klebsiella pneumoniae infection 1 Chlamydia psittaci pneumonia 1 COVID-19 pneumonia 1 Hospital-acquired pneumonia 1 Hypervirulent Klebsiella pneumoniae infection 1 Inflammatory pneumonia 1 Interstitial pneumonia with autoimmune features 1 Macrolide-resistant Mycoplasma pneumoniae pneumonia 1 Moderate to Severe Pneumonia 1 Necrotizing pneumonia 1 Pneumocystis jirovecii pneumonia 1 Trauma-associated pneumonia 1 Viral pneumonia 1 Acute Lipoid Pneumonia 0 Anthrax Pneumonia 0 Bronchopneumonia 0 Chlamydia pneumoniae infection 0 Chlamydial pneumonia 0

68 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Pneumonia

57 trials tracked for Pneumonia: 16 in phase 3 or 4 and 7 with published results. The most-cited published study has 148 citations.

57Trials tracked
16Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 7 Phase 3 9 Phase 2 11 Phase 1 3 Other / NA 27
  1. Phase 4 Trial to Evaluate Beta-Lactam Antimicrobial Therapy of Community Acquired Pneumonia in Children Completed · 148 cited
  2. Phase 3 Trial for the Treatment of Extensively Drug-Resistant Gram-negative Bacilli (OVERCOME) Completed · 138 cited
  3. Phase 3 Effectiveness of Etanercept for Idiopathic Pneumonia Syndrome Following Stem Cell Transplantation (BMT CTN 0403) Completed · 92 cited
  4. Phase 3 Tedizolid Phosphate (TR-701 FA, MK-1986) vs Linezolid for the Treatment of Nosocomial Pneumonia (MK-1986-002) Completed · 56 cited
  5. Phase 4 Rapid Empiric Treatment With Oseltamivir Study (RETOS) Completed · 44 cited
  6. Phase 4 Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures Completed · 10 cited
Show 44 more trials
  1. Phase 4 Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines Completed · 4 cited
  2. Phase 4 Multicenter Infection Surveillance Study Following Open Heart Surgery Completed
  3. Phase 4 Population Pharmacokinetics of Prolonged Infusion Meropenem in Cystic Fibrosis (CF) Children Completed
  4. Phase 4 PROUD Study: A Prospective Study on the Usage Patterns of Doripenem in the Asia Pacific Region Completed
  5. Phase 3 Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia Completed
  6. Phase 3 Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease Completed
  7. Phase 3 Study Comparing the Safety and Efficacy of Cethromycin to Clarithromycin for the Treatment of Community-Acquired Pneumonia Completed
  8. Phase 3 A Trial to Reduce Pneumonia in Nursing Home Residents Completed
  9. Phase 3 Study Comparing the Safety and Efficacy of Cethromycin to Clarithromycin for the Treatment of Community-Acquired Pneumonia (CAP) Completed
  10. Phase 3 CHIZAP: Community- and Health Facility-Based Intervention With Zinc as Adjuvant Therapy for Childhood Pneumonia Completed
  11. Phase 2 A Study of Auxora in Patients With Severe COVID-19 Pneumonia Completed
  12. Phase 2 An Effectiveness, Safety, and Microbiology Study of Doripenem in Patients With Nosocomial (Hospital-acquired) Pneumonia Completed
  13. Phase 2 Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia Completed
  14. Phase 2 A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia Completed
  15. Phase 2 Study to Evaluate the Efficacy and Safety of Intravenous Infusion With Nemonoxacin Malate Sodium Chloride Completed
  16. Phase 2 Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients Completed
  17. Phase 2 A Study of a Vaccine for Pneumonia in Adults and Toddlers in Kenya Completed
  18. Phase 2 Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation Completed
  19. Phase 2 Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation Completed
  20. Phase 2 Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia Completed
  21. Phase 2 Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation Completed
  22. Phase 1 A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function Completed
  23. Phase 1 Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007) Completed
  24. Phase 1 Procalcitonin to Reduce Antibiotic Use in Pediatric Pneumonia Completed
  25. N/A PATient Navigator to rEduce Readmissions Completed
  26. N/A Prophylactic Bronchoscopy After Inhalation Injury in Burn Patients Completed
  27. N/A Improving Oral Care to Reduce Hospital-Acquired Pneumonia (HAP) in the Acute Neurologically Impaired Adult Completed
  28. N/A Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed
  29. N/A Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years Completed
  30. N/A Zambia Integrated Management of Malaria and Pneumonia Study Completed
  31. N/A Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions Completed
  32. N/A PK Analysis of Moxifloxacin in the Treatment of CAP Completed
  33. N/A Reducing Length of Stay for Veterans Hospitalized With Pneumonia Completed
  34. N/A Special Use-Result Surveillance of Unasyn-S (Kit) for Intravenous Use - A Surveillance on High-dose (>6 g Daily) Administration - Completed
  35. N/A A Study To Learn About The Effects Of Pneumococcal Vaccine In People With HIV Completed
  36. N/A Prophylactic Efficacy of Relenza Against Influenza A and B Completed
  37. N/A The INSPIRE-ASP PNA Trial Completed
  38. N/A Inspiratory Strength and Respiratory Complications After SCI Injury Completed
  39. N/A The Place of Imaging and Microbiology in the Diagnosis of Pneumonia in the Elderly Completed
  40. N/A Clinical Outcomes of Methicillin Resistant Staphylococcus Aureus (MRSA) Hospital-Based Pneumonia Completed
  41. N/A The Effect of Postoperative Incentive Spirometry on Pulmonary Function and Pulmonary Complications in Bariatric Surgery Completed
  42. N/A Diagnostic Use of Lung Ultrasound for Suspected Pneumonia in Nepal Completed
  43. N/A Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program Completed
  44. N/A Dissemination and Implementation of a Videoconference Antimicrobial Stewardship Team Completed

Showing the 50 most-cited and recently-updated of 57 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Relaxation training and early benzodiazepines linked to respiratory recovery in adults with COPD, pneumonia, asthma, bronchiectasis, or interstitial lung disease
Rheumatology Cohort
Relaxation training and early benzodiazepines linked to respiratory recovery in adults with COPD, pneumonia, asthma, bronchiectasis, or interstitial lung disease Could early sedatives be slowing down lung recovery for adults with breathing problems?
This retrospective observational study examined 389 consecutive adults (≥ 18 years) admitted with chronic obstructive pulmonary disease, pne…
Early sedatives given to adults with breathing problems may slow lung recovery, making it harder for patients to improve before leaving the …
Frontiers Apr 18, 2026
tNGS in pediatric LRTIs shows higher Mycoplasma pneumoniae detection in severe vs non-severe CAP
Infectious Disease Cohort
tNGS in pediatric LRTIs shows higher Mycoplasma pneumoniae detection in severe vs non-severe CAP A new test found more germs in severe pediatric pneumonia cases than mild ones
A retrospective, single-center cohort study of 2,299 children with suspected lower respiratory tract infections found that targeted next-gen…
A new test found that severe pediatric pneumonia cases carry more germs than mild ones, revealing a link between specific microbial signatur…
Frontiers Apr 17, 2026
Whole-genome sequencing of 108 CRKP isolates from South China reveals ST11 dominance and emerging hvCRKP
Infectious Disease Cohort
Whole-genome sequencing of 108 CRKP isolates from South China reveals ST11 dominance and emerging hvCRKP Genomic analysis reveals resistance patterns in carbapenem-resistant Klebsiella pneumoniae from South China hospitals
This retrospective molecular epidemiology study characterized 108 carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from multiple h…
Genomic analysis of South China hospitals found a new KPC-12 variant in carbapenem-resistant bacteria, alongside mutations that make these g…
Frontiers Apr 17, 2026
Review of a case report on necrotizing laryngotracheobronchitis after Mycoplasma pneumoniae pneumonia
Pediatrics Sys. Review
Review of a case report on necrotizing laryngotracheobronchitis after Mycoplasma pneumoniae pneumonia Could a common infection trigger a rare, severe throat condition in a young boy?
This review summarizes a case report of a 7-year-old boy with necrotizing laryngotracheobronchitis following Mycoplasma pneumoniae pneumonia…
A common respiratory bug turned a seven-year-old boy's throat infection into a rare, severe condition requiring multiple airway washes to re…
Frontiers Apr 16, 2026
PBMC gene expression profiles differentiate refractory Mycoplasma pneumoniae pneumonia in children
Infectious Disease Cohort
PBMC gene expression profiles differentiate refractory Mycoplasma pneumoniae pneumonia in children New Blood Test Distinguishes Severe Lung Infection Early
This cohort study of 349 children identified peripheral blood mononuclear cell gene expression profiles as potential biomarkers for refracto…
A new four-gene blood test helps doctors spot severe, hard-to-treat pneumonia in children before symptoms get too bad to fix easily.
Frontiers Apr 16, 2026
Systemic Immune-Inflammation Index predicts severe community-acquired pneumonia in pediatric patients
Pediatrics Cohort
Systemic Immune-Inflammation Index predicts severe community-acquired pneumonia in pediatric patients High Blood Markers Signal Dangerous Pneumia in Kids
This retrospective analysis evaluated 595 pediatric patients to assess the Systemic Immune-Inflammation Index (SII) for predicting severe pn…
A simple blood test number called SII helps doctors spot dangerous pneumonia in children before their lungs fill with fluid.
Frontiers Apr 16, 2026
Ensemble MLLM strategies improve diagnostic performance for paediatric pneumonia on CXRs
Radiology & Imaging Cohort
Ensemble MLLM strategies improve diagnostic performance for paediatric pneumonia on CXRs AI Team Reads Kids' X-Rays Faster Than Waiting for Specialists
A retrospective cohort study of 2300 CXRs from paediatric patients at two hospitals found that ensemble strategies with MLLMs, such as Soft …
Fifteen AI agents working together spot pneumonia on children's chest X-rays more accurately than a single model, offering faster care in bu…
medRxiv Apr 16, 2026
Review of observational data on pneumonia biomarkers in Kenyan children
Infectious Disease
Review of observational data on pneumonia biomarkers in Kenyan children Why pneumonia tests still miss the mark
This narrative review synthesizes findings from an observational study of 457 children aged 2-59 months admitted to Kilifi County Referral H…
Even the best new tools cannot yet tell if a child's pneumonia is bacterial or viral without more research.
medRxiv Apr 16, 2026
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Infectious Disease Meta-analysis
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…
Apr 14, 2026
Pyroptosis endotypes and malnutrition linked to mortality in older adults with community-acquired pneumonia
Allergy & Immunology Cohort
Pyroptosis endotypes and malnutrition linked to mortality in older adults with community-acquired pneumonia High inflammation markers linked to higher death risk in older pneumonia patients
This retrospective cohort study evaluated 282 hospitalized older adults (aged ≥75 years) with community-acquired pneumonia.
Older pneumonia patients with high inflammation markers faced a 57.5% death risk, while those with low levels had only 1.2% mortality within…
Frontiers Apr 14, 2026
Atopic constitution associated with severe Mycoplasma pneumoniae pneumonia in children
Dermatology Cohort
Atopic constitution associated with severe Mycoplasma pneumoniae pneumonia in children Why Allergy-Prone Kids Get Sicker From This Common Lung Infection
This retrospective cohort study examined 377 children with Mycoplasma pneumoniae pneumonia at Wuhan Children's Hospital.
Allergy-prone children face a higher risk of severe pneumonia from Mycoplasma, and two simple blood tests could flag who needs closer watchi…
Frontiers Apr 14, 2026
In hospitalized children with human rhinovirus infection, lower airway obstruction and specific comorbidities associate with progression to bronchitis or pneumonia
Pediatrics Cohort
In hospitalized children with human rhinovirus infection, lower airway obstruction and specific comorbidities associate with progression to bronchitis or pneumonia Rhinovirus infection linked to higher risk of bronchitis or pneumonia in hospitalized children
This retrospective cohort study examined 1,125 hospitalized children with human rhinovirus infection to identify risk factors for disease pr…
Children with rhinovirus infections and shortness of breath face a 4.35 times higher risk of developing bronchitis during their hospital sta…
Frontiers Apr 14, 2026

Questions about Pneumonia

Can the SII score tell if a child will get severe pneumonia?

Research shows the Systemic Immune-Inflammation Index (SII) can help predict severe pneumonia in children, with higher scores indicating greater risk.

Full answer →
Which blood inflammation numbers predict death in severe pneumonia patients?

Several blood inflammation numbers, specifically the Systemic Inflammatory Response Index (SIRI) and the Neutrophil-to-Lymphocyte Ratio (NLR), are linked to higher death rates in severe pneumonia patients.

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Can gut bacteria changes predict sepsis in kids with severe pneumonia?

Changes in gut bacteria can predict sepsis in young children with severe pneumonia, showing distinct microbial patterns that differ between those who develop sepsis and those who do not.

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What pneumonia biomarkers are common in Kenyan children?

In Kenyan children with pneumonia, common biomarkers include procalcitonin (PCT), lipocalin 2 (Lpc-2), haptoglobin, angiotensinogen, and Serpin Family A Member 1.

Full answer →
Can exhaled breath tests like AveloMask replace lung swabs for pneumonia?

AveloMask shows promise for detecting pneumonia pathogens but cannot yet replace lung swabs due to lower sensitivity for low-abundance bugs.

Full answer →
See all 5 questions about Pneumonia →