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Home › Conditions › Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder

Subtypes of Post-Traumatic Stress Disorder

Posttraumatic Stress Disorder 10 Moral Injury 2

29 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Post-Traumatic Stress Disorder

227 trials tracked for Post-Traumatic Stress Disorder: 37 in phase 3 or 4 and 17 with published results. The most-cited published study has 260 citations.

227Trials tracked
37Phase 3 & 4
0Recruiting
17With published results
Phase distribution
Phase 4 22 Phase 3 15 Phase 2 36 Phase 1 7 Other / NA 147
  1. Phase 4 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed · 260 cited
  2. Phase 4 Primary Care Intervention Strategy for Anxiety Disorders Completed · 240 cited
  3. Phase 4 Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments Completed · 177 cited
  4. Phase 4 Effect of Propranolol on Preventing Posttraumatic Stress Disorder Completed · 172 cited
  5. Phase 3 Comparison of Two Treatments for Post-Traumatic Stress Disorder Completed · 121 cited
  6. Phase 3 Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer Completed · 60 cited
Show 44 more trials
  1. Phase 4 Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy Completed · 46 cited
  2. Phase 3 Frontline Clinician Psilocybin Study Completed · 32 cited
  3. Phase 4 Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753) Completed · 12 cited
  4. Phase 4 Vortioxetine for Posttraumatic Stress Disorder Completed · 12 cited
  5. Phase 3 Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSD Completed · 12 cited
  6. Phase 4 Atomoxetine in Veterans With Comorbid ADHD/PTSD Completed · 8 cited
  7. Phase 3 Progesterone Effect on Individuals Diagnoses With AD and PTSD. Completed · 8 cited
  8. Phase 4 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Completed · 4 cited
  9. Phase 3 Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD Completed · 4 cited
  10. Phase 4 Sequenced Treatment Effectiveness for Posttraumatic Stress Completed · 2 cited
  11. Phase 3 Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress Disorder Completed
  12. Phase 4 Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder Completed
  13. Phase 4 Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems Completed
  14. Phase 4 Dexamethasone Plus Virtual Reality Exposure Therapy for PTSD Completed
  15. Phase 4 Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD) Completed
  16. Phase 4 Short Course Glucocorticoid Treatment for PTSD Completed
  17. Phase 4 Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Completed
  18. Phase 4 Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder Completed
  19. Phase 4 A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health Completed
  20. Phase 4 A Placebo-Controlled Study of Mirtazapine for PTSD Completed
  21. Phase 4 Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD) Completed
  22. Phase 4 Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder Completed
  23. Phase 4 Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy Completed
  24. Phase 3 Ketamine Infusion for Comorbid PTSD and Chronic Pain Completed
  25. Phase 3 A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD Completed
  26. Phase 3 A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD Completed
  27. Phase 3 Estrogen and Fear in PTSD Completed
  28. Phase 3 Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities Completed
  29. Phase 3 Naltrexone & SSRI in Alcoholics With Depression/PTSD Completed
  30. Phase 3 Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Completed
  31. Phase 3 D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD Completed
  32. Phase 2 Phase II Study of BNC210 in PTSD Completed
  33. Phase 2 Treatment of Smoking Among Individuals With PTSD Completed
  34. Phase 2 Cannabidiol as a Treatment for AUD Comorbid With PTSD Completed
  35. Phase 2 A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder Completed
  36. Phase 2 Prolonged Exposure and Oxytocin Completed
  37. Phase 2 Sex/Gender Differences in Risk and Resilience to PTSD; Implication of Oxytocin Completed
  38. Phase 2 Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence Completed
  39. Phase 2 Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth Completed
  40. Phase 2 Methylphenidate for Ptsd and Stroke Veterans Completed
  41. Phase 2 Safety and Efficacy of NYX-783 in Subjects With Post-Traumatic Stress Disorder Completed
  42. Phase 2 A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD) Completed
  43. Phase 2 Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD Completed
  44. Phase 2 D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents Completed

Showing the 50 most-cited and recently-updated of 227 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Hyperbaric oxygen therapy associated with improved sleep quality in retrospective cohort study
Neurology Cohort
Hyperbaric oxygen therapy associated with improved sleep quality in retrospective cohort study Hyperbaric oxygen therapy linked to improved sleep quality in retrospective study
A retrospective longitudinal cohort study of 395 patients undergoing hyperbaric oxygen therapy for healthy aging, long COVID, or PTSD found …
Patients treated with hyperbaric oxygen therapy for aging, long COVID, or PTSD all reported significantly better sleep quality after complet…
Frontiers Apr 3, 2026
Flood exposure associated with elevated odds of PTSD, depression, and anxiety in affected populations
Psychiatry Meta-analysis
Flood exposure associated with elevated odds of PTSD, depression, and anxiety in affected populations Flood exposure linked to higher odds of PTSD, depression, and anxiety
A systematic review and meta-analysis of 107 studies, with 18 included in quantitative synthesis, found flood exposure was associated with s…
People exposed to flooding face three times higher odds of PTSD, double the risk of depression, and nearly triple the risk of anxiety compar…
Apr 2, 2026
Meta-analysis finds virtual reality exposure therapy reduces anxiety and PTSD symptoms
Psychiatry Meta-analysis
Meta-analysis finds virtual reality exposure therapy reduces anxiety and PTSD symptoms Can virtual reality help people face their fears? A new analysis suggests it might
A meta-analysis of 26 RCTs involving 1,649 patients with anxiety-related disorders and PTSD found virtual reality exposure therapy significa…
Virtual reality exposure therapy significantly reduces phobia, anxiety, and PTSD symptoms while helping people face their deepest fears.
Apr 2, 2026
Systematic review finds elevated heart rate post-trauma associated with PTSD persistence in children
Pediatrics Meta-analysis
Systematic review finds elevated heart rate post-trauma associated with PTSD persistence in children Elevated heart rate after trauma linked to persistent PTSD risk in children
A systematic review and meta-analysis of 21 studies examined prospective biomarkers for PTSD in children and young people exposed to trauma.
A faster heart rate right after trauma may signal that a child is at higher risk for long-lasting PTSD symptoms, according to a new review.
Apr 2, 2026
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use
Psychiatry Phase IV
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use Could Ketamine Be the Key to Easing Pain and Healing Minds After Surgery?
This Phase 4 trial investigates ketamine's efficacy in reducing postoperative pain and opioid use in orthopedic trauma patients.
A new trial tests if giving ketamine during orthopedic surgery reduces pain, opioid needs, and symptoms of depression and PTSD compared to s…
CT.gov Mar 27, 2026

Questions about Post-Traumatic Stress Disorder

Can hyperbaric oxygen therapy improve sleep quality for patients with PTSD?

Yes, hyperbaric oxygen therapy (HBOT) may improve sleep quality in PTSD patients, based on studies showing significant reductions in sleep disturbance scores.

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Is there a trial testing hydrocortisone to prevent PTSD after a traumatic event?

Yes, a 2024 Cochrane review found no clear evidence that hydrocortisone prevents PTSD after trauma, though some older studies suggested possible benefit.

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Do mental health issues like depression reduce HIV medicine success in Post-Traumatic Stress Disorder patients?

Yes, mental health issues like depression can reduce HIV medicine success in PTSD patients by worsening adherence to antiretroviral therapy and viral suppression.

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Does watching uncensored traumatic videos make Post-Traumatic Stress Disorder symptoms worse?

Yes, watching uncensored traumatic videos is linked to worse PTSD symptoms, even in people not directly exposed to the trauma.

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Can lay providers deliver COMPASS CBT for Post-Traumatic Stress Disorder in Peru?

Yes, COMPASS CBT is designed for lay providers in Peru, with a pilot trial underway to test its effectiveness for PTSD in Venezuelan migrants.

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See all 5 questions about Post-Traumatic Stress Disorder →