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Home › Conditions › Preeclampsia

Preeclampsia

Part of Pregnancy induced hypertension

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Preeclampsia

19 trials tracked for Preeclampsia: 8 in phase 3 or 4 and 6 with published results. The most-cited published study has 402 citations.

19Trials tracked
8Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 3 Phase 3 5 Phase 2 1 Phase 1 1 Other / NA 9
  1. Phase 3 Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) Completed · 402 cited
  2. Phase 3 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed · 165 cited
  3. Phase 3 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed · 117 cited
  4. Phase 4 Magnesium Sulfate in Obese Preeclamptics Completed · 20 cited
  5. Phase 4 Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia Completed · 17 cited
  6. Phase 3 Low Doses of Aspirin in the Prevention of Preeclampsia Completed · 4 cited
Show 13 more trials
  1. Phase 4 Response to Anti-hypertensives in Pregnant and Postpartum Patients Completed
  2. Phase 3 Antioxidant Supplementation in Pregnant Women Completed
  3. Phase 2 ToRsemide for pOstpartum HYpertension Completed
  4. Phase 1 Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia Completed
  5. N/A Nudge to Drive Transitions of Care Completed
  6. N/A Study of Positive Airway Pressure in Preeclampsia to Reduce Blood Pressure Completed
  7. N/A Heart Health 4 Moms Trial to Reduce CVD Risk After Preeclampsia Completed
  8. N/A Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Case-control Study Completed
  9. N/A Postpartum Weight Loss for Women at Elevated Cardiovascular Risk Completed
  10. N/A Phenylephrine in Spinal Anesthesia in Preeclamptic Patients Completed
  11. N/A App-based Remote Blood Pressure Monitoring Completed
  12. N/A Pregnancy-Related Hypertension: Adherence to a New Type of Monitoring Completed
  13. N/A Platelet Count Trends in Pre-eclamptic Parturients Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Diabetes & Endocrinology Sys. Review
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
Frontiers Apr 12, 2026
N-acetylcysteine protocol study for early-onset preeclampsia progression in Lagos, Nigeria
OB/GYN & Women's Health RCT
N-acetylcysteine protocol study for early-onset preeclampsia progression in Lagos, Nigeria NAC study protocol for early-onset preeclampsia in Lagos hospitals planned for 2026 to 2028
This study protocol outlines a planned proof-of-concept trial evaluating daily oral N-acetylcysteine versus placebo in sexually active women…
A planned 2026 trial in Lagos hospitals will test if a daily antioxidant tablet slows the progression of early-onset preeclampsia in pregnan…
medRxiv Apr 9, 2026
Maternal APOL1 risk alleles show no independent association with preeclampsia risk in multi-ethnic study
OB/GYN & Women's Health Case-Control
Maternal APOL1 risk alleles show no independent association with preeclampsia risk in multi-ethnic study Study finds no link between maternal APOL1 gene variants and preeclampsia risk
A nested case-control study of 5210 pregnant women found no significant association between maternal APOL1 G1/G2 risk alleles and preeclamps…
A new genetic study of over 5,000 pregnant women found that carrying two APOL1 risk variants did not increase a mother's chance of developin…
medRxiv Apr 4, 2026
Higher uric acid-to-creatinine ratio linked to preeclampsia risk in advanced maternal age pregnancy
Cardiology Cohort
Higher uric acid-to-creatinine ratio linked to preeclampsia risk in advanced maternal age pregnancy Higher uric acid ratio linked to increased preeclampsia risk in older pregnant women
A retrospective cohort study of 2,296 pregnant women aged ≥35 years found each standard deviation increase in serum uric acid-to-creatinine …
Older pregnant women with higher uric acid-to-creatinine ratios face 29% greater odds of developing preeclampsia, a serious condition affect…
Frontiers Apr 2, 2026

Questions about Preeclampsia

How do social factors affect preeclampsia in Black and African American women?

Social factors like structural racism, limited healthcare access, and chronic stress increase preeclampsia risk in Black women, interacting with genetic and biological pathways.

Full answer →
What neuroimmune mechanisms cause preeclampsia according to recent reviews?

Recent reviews highlight that preeclampsia involves dysregulated neuro-immune-vascular integration, including autonomic dysfunction, neuropeptide signaling, and cerebral autoregulatory failure, alongside classic placental and immune factors.

Full answer →
Does a high TyG index in early pregnancy increase preeclampsia risks?

Yes, a high TyG index in early pregnancy is significantly linked to increased preeclampsia risk, based on a large meta-analysis of 23 studies.

Full answer →