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Home › Conditions › Respiratory Disease

Respiratory Disease

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Respiratory Disease

28 trials tracked for Respiratory Disease: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 432 citations.

28Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 8 Phase 1 3 Other / NA 12
  1. Phase 3 Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease Completed · 432 cited
  2. Phase 4 Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS) Completed · 129 cited
  3. Phase 4 The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19 Completed · 1 cited
  4. Phase 4 Treatment of Acute Sinusitis Completed
  5. Phase 3 Efficacy and Safety of Polyoxidonium, Nasal and Sublingual Spray, 6 mg/ml in Children Aged 1-12 Years With ARI Completed
  6. Phase 2 Evaluation of the Effect of AZD5069 in Patients With Bronchiectasis Completed
Show 22 more trials
  1. Phase 2 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GlaxoSmithkline (GSK) Biologicals' Investigational Vaccine GSK2838504A When Administered to Chronic Obstructive Pulmonary Disease (COPD) Patients With Persistent Airflow Obstruction. Completed
  2. Phase 2 Study to Assess the Immunogenicity and Safety of GSK's Investigational Vaccine (GSK3277511A) When Given to Healthy Smokers and Ex-smokers After Administration of Shingrix Vaccine Completed
  3. Phase 2 Vitamin D for Sickle-cell Respiratory Complications Completed
  4. Phase 2 A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine Completed
  5. Phase 2 A Study to Test if the Vaccine is Working Well in Chronic Obstructive Pulmonary Disease (COPD) Patients Aged 40 to 80 Years Old to Reduce Episodes of Worsening Symptoms and to Gather Further Information on Safety and Immune Response. Completed
  6. Phase 2 University of Wisconsin Meditation & Exercise Cold Study Completed
  7. Phase 2 Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection Completed
  8. Phase 1 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the Investigational GSK Biologicals' GSK3277511A Vaccine in Adults. Completed
  9. Phase 1 A Long Term Follow-up Study up to 4 Years After Study Vaccination to Assess Immunogenicity and Safety of the Investigational Vaccine in Adults Completed
  10. Phase 1 Study to Evaluate the AIO-001 in Healthy Participants Completed
  11. N/A A Study to Assess Immunity to Specific Microbial Antigens in Healthy Smokers and Non-smokers and in Subjects With Stable COPD Completed
  12. N/A Infectious Pathogens in Acute Respiratory Illness in Adults and Elderly Completed
  13. N/A Utility of Continuous Pulse Oximetry for Pediatric Patients With Stable Respiratory Illness Completed
  14. N/A Prophylactic Efficacy of Relenza Against Influenza A and B Completed
  15. N/A Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway Completed
  16. N/A Initial Specialist Telephone Consultation With New Patients in Secondary Care Completed
  17. N/A Comparing 6-Minute Walk Tests for Ambulatory Oxygen Assessment Completed
  18. N/A A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters Completed
  19. N/A Engineering Evaluation of the Helix Ventilator Completed
  20. N/A Timing of Planned Caesarean Section and Morbidity of the Newborn Completed
  21. N/A Occurrence of Potential Bacterial and Viral Pathogens in Stable Chronic Obstructive Pulmonary Disease and During Acute Exacerbations of the Disease, in Asia Pacific Completed
  22. N/A FluSAFE: Flu SMS Alerts to Freeze Exposure Completed

Showing the 28 most-cited and recently-updated of 28 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Respiratory Disease: what the trials found

Nintedanib was evaluated for its impact on lung imaging and weight loss in patients with respiratory disease, showing a reduction in Chest CT Visual Scores (-4.49 and -4.06) and no instances of 10% weight loss at 90 or 180 days 1. Polyoxidonium (6 mg/ml) demonstrated significant efficacy in reducing fever duration (p<0.05), improving intoxication symptoms as measured by the Symptom Assessment Scale (p<0.05), and reducing nasal discharge symptoms (p<0.05) 6.

In the context of COPD, Roflumilast did not show a statistically significant effect on the rate of moderate or severe exacerbations (p=0.1634), nor on the rate of severe exacerbations leading to hospitalization or death (p=0.6354) 3. Similarly, an investigational NTHi/Mcat vaccine (GSK3277511A) showed no significant difference in the rate of moderate and severe AECOPD over a one-year period compared to control groups (p=0.8157) 9. Safety data for this vaccine indicated specific counts of local and general adverse events across different schedules 10.

Other findings include that Acetaminophen did not significantly impact SNOT-16 scores at Day 3 (p=0.83) 4. Hydroxychloroquine was evaluated in COVID patients, with consistent outcomes observed on the COVID Outcomes Scale and COVID Ordinal Outcomes Scale at various intervals post-randomization 5.

Recent results — preliminary, needs further review

  • * A study on Maximal 6-minute Walk Test (Max_6MWT) found that while there was no significant difference in the time taken to reach SpO2 nadir (p=0.50), there were significant differences in average drop in SpO2 from baseline and the Nadir SpO2 percentage between maximal and normal walking speeds (p<0.01) 2. * A Phase 1 trial for AIO-001 was recently conducted 15.

For the clinician treating this condition

  • Nintedanib is associated with improved Chest CT Visual Scores in patients with respiratory disease 1.
  • Polyoxidonium (6 mg/ml) significantly reduces fever duration and improves symptoms related to nasal discharge and intoxication 6.
  • Roflumilast and the NTHi/Mcat vaccine (GSK3277511A) did not show statistically significant differences in exacerbation rates for COPD patients in the studied trials [3, 9].

AI synthesis of 9 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Tai Chi reduces inflammatory gene expression in chronic disease patients
Oncology Meta-analysis
Tai Chi reduces inflammatory gene expression in chronic disease patients Tai Chi Calms Inflammation Genes in Chronic Disease Patients
A meta-analysis of 20 studies shows Tai Chi significantly downregulates pro-inflammatory genes like IL-6 and IL-1β in adults with chronic di…
A new review shows Tai Chi may quiet the body's inflammatory genes that drive chronic disease symptoms in adults.
Frontiers May 6, 2026
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico
Primary Care & Family Medicine Sys. Review
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico Air pollution may change your body’s microbes and raise cancer risk
This perspective review examines the impact of chronic air pollution and environmental exposures on children and older adults.
Tiny particles in the air we breathe may be altering the body’s microbiome and increasing cancer risk, especially in kids and older adults l…
Frontiers May 1, 2026
Effort Re-education Programme improves functionality in oncology patients with respiratory symptoms
Oncology RCT
Effort Re-education Programme improves functionality in oncology patients with respiratory symptoms Effort Re-education Programme improves function for oncology patients
In this stratified randomised clinical trial of 65 oncology patients, an Effort Re-education Programme (ERP) delivered after hospital discha…
A new breathing program may help oncology patients regain independence and reduce shortness of breath after leaving the hospital.
Apr 30, 2026
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models
Primary Care & Family Medicine Meta-analysis
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models E-cigarette flavors may increase nicotine use and health risks
This systematic review examines the health impacts of fruity, menthol/mint, and sweet e-cigarette flavors using animal models and human data…
Sweet, fruity, and minty e-cigarette flavors are linked to higher nicotine use and serious respiratory and cellular damage.
Frontiers Apr 30, 2026
Narrative review explores transcranial magnetic stimulation feasibility for chronic respiratory diseases
Physical Medicine & Rehab Sys. Review
Narrative review explores transcranial magnetic stimulation feasibility for chronic respiratory diseases New ideas for managing chronic respiratory diseases using brain stimulation
This narrative review evaluates the feasibility of transcranial magnetic stimulation as an adjunctive respiratory training approach for pati…
This review explores using transcranial magnetic stimulation to help patients with chronic respiratory disorders breathe easier and manage t…
Frontiers Apr 29, 2026
Cochrane review finds vitamin D may slightly reduce ARI healthcare visits in children
Gastroenterology Sys. Review
Cochrane review finds vitamin D may slightly reduce ARI healthcare visits in children Vitamin D may slightly cut cold visits for kids, but safety is key
This Cochrane systematic review of 31,521 participants found that vitamin D supplementation may slightly reduce the proportion of children w…
A large review of 31,521 people found vitamin D might slightly reduce cold visits for children, though it does not lower the average number …
Cochrane Apr 27, 2026
Mathematical modelling review quantifies ethnic disparities in respiratory infection transmission dynamics across England
Infectious Disease
Mathematical modelling review quantifies ethnic disparities in respiratory infection transmission dynamics across England Why Some Groups Catch More Viruses Than Others
This mathematical modelling review synthesizes data from the 2024-2025 Reconnect social contact survey involving 12,484 participants in Engl…
Where you live and who you meet changes your risk of catching a respiratory virus.
medRxiv Apr 21, 2026
Systematic review of public health interventions to curb respiratory infections at sporting mass gatherings
Dermatology Meta-analysis
Systematic review of public health interventions to curb respiratory infections at sporting mass gatherings How Sports Events Can Stop Virus Spread
This systematic review synthesized 34 articles covering 37 sporting mass gatherings, most commonly the Olympic Games, to map public health i…
Smart planning at big sports events can safely protect fans and athletes from catching respiratory infections.
Frontiers Apr 16, 2026
Hospital at home reduces length of stay and 30-day readmissions in patients with heart, airway, or respiratory conditions
Pediatrics Cohort
Hospital at home reduces length of stay and 30-day readmissions in patients with heart, airway, or respiratory conditions Could keeping sick patients at home save days in the hospital and lower costs?
A retrospective cohort study in England of 2,972 HAH episodes and matched inpatient controls found HAH reduced length of stay by 3.13 days a…
Hospital at home care in England cut hospital stays by over 3 days and lowered 30-day readmission rates by nearly half compared to tradition…
Frontiers Apr 14, 2026
Openness-based psychoeducational booklet improved SGRQ activities in chronic respiratory disease patients during inpatient pulmonary rehabilitation
Primary Care & Family Medicine RCT
Openness-based psychoeducational booklet improved SGRQ activities in chronic respiratory disease patients during inpatient pulmonary rehabilitation Openness booklet improved activity scores in pulmonary rehab patients
This randomized controlled trial enrolled 136 participants with chronic respiratory disease undergoing inpatient pulmonary rehabilitation.
An openness-focused booklet helped pulmonary rehab patients improve their ability to perform daily activities, even though their overall qua…
Apr 6, 2026
DaRRE strategy implemented in Kenya for respiratory disease outbreak response
Infectious Disease
DaRRE strategy implemented in Kenya for respiratory disease outbreak response Kenya tests new strategy to detect and respond to respiratory disease outbreaks
A strategy for Detection and Response to Respiratory Events (DaRRE) was implemented in Kenya.
Kenya pilots a new strategy to help health officials find and respond to respiratory disease outbreaks more effectively.
CDC Apr 6, 2026
Surveillance report describes respiratory virus patterns in children with acute respiratory illnesses
Pediatrics
Surveillance report describes respiratory virus patterns in children with acute respiratory illnesses U.S. surveillance tracks respiratory viruses in children with acute illnesses
A surveillance report from the United States describes respiratory virus patterns among children with acute respiratory illnesses.
U.S. health officials are tracking respiratory viruses in sick children to watch for patterns, but this report offers no new medical guidanc…
CDC Apr 4, 2026

Questions about Respiratory Disease

Do cohort studies show clinical outcomes for pediatric acute respiratory infections?

Yes, cohort studies are the most common study type in pediatric ARI research, providing key data on pathogen profiles, co-infections, seasonal patterns, and clinical outcomes like hospitalization and severity.

Full answer →
How does chronic air pollution affect children and older adults in Puerto Rico?

Chronic air pollution in Puerto Rico increases risks of cancer, respiratory, and cardiovascular diseases, especially in children and older adults, through microbiome disruption and immune dysregulation.

Full answer →