Meta-analysis finds trivial cognitive effects of amyloid antibodies in mild Alzheimer's disease
Alzheimer’s Drugs Clear Plaques But Don’t Help Memory
This meta-analysis of 17 randomized trials found amyloid-beta-targeting monoclonal antibodies probably have little to no effect on cognitive…
This review shows that even when Alzheimer’s drugs clear amyloid from the brain, patients don’t see meaningful improvements in memory or dai…
Narrative review covers cardiovascular conditions and cognitive decline without reported trial data
Your Heart and Brain Are Talking to Each Other
This narrative review addresses a broad scope of cardiovascular conditions, including stroke, heart failure, atrial fibrillation, and ischem…
Imagine your heart and brain as two best friends who never stop texting each other.
Parecoxib reduces postoperative anxiety but not cognitive decline in pancreaticoduodenectomy patients
Pain Drug Cuts Anxiety After Major Surgery
This randomized controlled trial of 80 patients undergoing laparoscopic pancreaticoduodenectomy evaluated intravenous parecoxib versus salin…
A common pain drug called parecoxib significantly lowers anxiety and may reduce mental fog for patients recovering from major pancreatic sur…
CABG linked to higher impaired cognition risk in older CAD patients with APO genotype variation
Heart Surgery Tied to Memory Issues in Some Patients
This cohort study of older adults with coronary artery disease found that coronary artery bypass grafting was associated with a higher risk …
Heart bypass surgery may raise memory problem risks in older adults, especially those carrying a specific gene type linked to brain health.
Cognitive Remediation Therapy Re-analysis Shows Benefit Over Treatment As Usual on Global Assessment Scale
When Patients Rank Treatment Success Differently Than Doctors
This re-analysis of a randomized controlled trial evaluated Cognitive Remediation Therapy versus treatment as usual among participants and s…
Patients and doctors value different treatment benefits, and letting patients help decide what counts as success can change how we understan…
Poor multidimensional sleep health associated with cognitive impairment in middle-aged adults
One Simple Sleep Question Could Flag Early Brain Decline in Midlife
This cross-sectional analysis of 646 English-speaking adults aged 35 to 64 years found that poor multidimensional sleep health was associate…
A simple sleep question in your midlife checkup could help doctors spot early brain health risks before serious problems appear.
Phase 2b trial finds basmisanil does not improve cognitive deficits in schizophrenia
Schizophrenia Drug Failed to Fix Thinking Skills
A Phase 2b multicenter RCT randomized 213 patients with cognitive impairment associated with schizophrenia to basmisanil (80 mg or 240 mg tw…
A schizophrenia drug that improved thinking skills in animals failed to help human patients improve their cognitive function in a clinical t…
Virtual reality cognitive training shows benefit on cognition in older adults with mild cognitive impairment
Virtual Reality Training Helps Older Adults Keep Their Minds Sharp
This PRISMA-guided systematic review and meta-analysis of randomized controlled trials pooled 19 studies identified from 2,433 screened reco…
Virtual reality training helps older adults with mild cognitive impairment improve memory and daily living skills without boring homework.
Review of bilingualism effects on naming performance in Catalan-Spanish speakers with cognitive impairment
Why Knowing Two Languages Changes the Story
This narrative review synthesizes observational evidence on bilingualism and naming performance in Catalan-Spanish bilinguals with Alzheimer…
Active bilinguals with early memory loss made more naming errors than those who only knew one language well, showing that fluency matters fo…
Systematic review finds exercise prescription linked to mood, cognition, and stress resilience benefits
Your Workout May Boost Mood Through Your Gut, Not Just Your Brain
A systematic review suggests exercise prescription is associated with advantageous impacts on mood, cognitive function, and stress resilienc…
Daily exercise may lift your mood by changing gut bacteria to produce mood-boosting molecules that signal your brain.
REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data
Can a new computer tool help doctors spot brain diseases faster and more accurately?
This study developed a machine learning framework called REDDI that utilizes MEG resting-state data and Riemannian geometry for classifying…
A new computer tool helps doctors distinguish between hard-to-tell-apart brain diseases like Parkinson's and ALS with 13% better accuracy.
Hearing aid use associated with improved cognition and reduced cognitive impairment risk in older adults
Hearing Aids Do More Than Help You Hear — They May Protect Your Memory
This systematic review and meta-analysis of 231,565 older adults with hearing loss evaluated the association between hearing aid use and cog…
Older adults with hearing loss who use hearing aids show better memory, sharper attention, and significantly lower rates of cognitive declin…
Questions about Cognitive Dysfunction
How common is cognitive dysfunction in children who have had a liver transplant?
About 24% of children who have a liver transplant experience cognitive dysfunction, with higher rates in those transplanted before age 1 (39.4%) and in Asia (30.6%).
Full answer →