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Home › Conditions › Osteoarthritis

Osteoarthritis

Part of Arthritis

Subtypes of Osteoarthritis

Glenohumeral Osteoarthritis 1 Non-radiographic osteoarthritis 1 Radiographic osteoarthritis 1 Thumb osteoarthritis 0 Trapeziometacarpal joint osteoarthritis 0

25 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Osteoarthritis

237 trials tracked for Osteoarthritis: 82 in phase 3 or 4 and 14 with published results. The most-cited published study has 3532 citations.

237Trials tracked
82Phase 3 & 4
0Recruiting
14With published results
Phase distribution
Phase 4 33 Phase 3 49 Phase 2 21 Phase 1 4 Other / NA 130
  1. Phase 3 Intra-Articular Injections of Platelet-Rich Plasma in Knee Osteoarthritis: Unique Application Versus Triple Application Completed · 3,532 cited
  2. Phase 3 Tanezumab in Osteoarthritis of the Knee Completed · 148 cited
  3. Phase 3 Tanezumab in Osteoarthritis Of The Hip Completed · 148 cited
  4. Phase 3 Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) Completed · 107 cited
  5. Phase 3 Tanezumab In Osteoarthritis Of The Knee (2) Completed · 86 cited
  6. Phase 3 Tanezumab in Osteoarthritis of the Hip or Knee (2) Completed · 86 cited
Show 44 more trials
  1. Phase 3 A Study of Duloxetine in Participants With Chronic Pain Due to Osteoarthritis in China Completed · 71 cited
  2. Phase 3 Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis Completed · 52 cited
  3. Phase 4 Tranexamic Acid in Knee Joint Surgery Completed · 38 cited
  4. Phase 3 Testosterone Administration and ACL Reconstruction in Men Completed · 24 cited
  5. Phase 4 Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain Completed · 23 cited
  6. Phase 3 Randomized Study of the Efficacy and Safety of a Single Dose of Synvisc-One® in Chinese Patients With Symptomatic Osteoarthritis of the Knee Completed · 14 cited
  7. Phase 3 Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement Completed · 2 cited
  8. Phase 3 Understanding Cognition, Oxytocin & Pain in Elders Completed · 1 cited
  9. Phase 4 Efficacy and Safety of Buprenorphine Transdermal Patch in Non-cancer Pain of Moderate Intensity Completed
  10. Phase 4 Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical Completed
  11. Phase 4 Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis Completed
  12. Phase 4 Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty Completed
  13. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  14. Phase 4 Pain Expectations in Subjects With Osteoarthritis Completed
  15. Phase 4 Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty Completed
  16. Phase 4 Sigma CR150 Versus Sigma CR Knee RCT Completed
  17. Phase 4 Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty Completed
  18. Phase 4 Topical Tranexamic Acid (TXA) in Joint Arthroplasty Completed
  19. Phase 4 Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis Completed
  20. Phase 4 Colchicine for the Treatment of Osteoarthritis of the Knee Completed
  21. Phase 4 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Completed
  22. Phase 4 A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis Completed
  23. Phase 4 Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly Completed
  24. Phase 4 Hormone Function in Men Treated for Pain With Opioids or Placebo Completed
  25. Phase 4 Duloxetine in Osteoarthritis (OA) Pain Completed
  26. Phase 4 Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment Completed
  27. Phase 4 Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis Completed
  28. Phase 4 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed
  29. Phase 4 A Study of the Efficacy and Safety of Synvisc® in Chinese Subjects With Symptomatic Osteoarthritis of the Knee(s) Completed
  30. Phase 4 Time of Intravenous Acetaminophen Administration Completed
  31. Phase 4 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Participants With Osteoarthritis Completed
  32. Phase 4 The 3DKnee™ System: A Post-Market Study Completed
  33. Phase 4 A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis Completed
  34. Phase 4 The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery Completed
  35. Phase 4 An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain Completed
  36. Phase 4 The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty Completed
  37. Phase 4 An Efficacy, Safety and Effects on Quality of Life of Tramadol/Paracetamol as Add-on Therapy in Chronic Osteoarthritis Completed
  38. Phase 4 Range of Motion of Standard and High-Flexion Posterior Cruciate Retaining Total Knee Prostheses Completed
  39. Phase 4 Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty Completed
  40. Phase 3 Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe Completed
  41. Phase 3 To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion). Completed
  42. Phase 3 A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb Completed
  43. Phase 3 Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty Completed
  44. Phase 3 Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain Completed

Showing the 50 most-cited and recently-updated of 237 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis finds no clinically significant outcome differences with postoperative glenoid retroversion ≥15° after aTSA
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis finds no clinically significant outcome differences with postoperative glenoid retroversion ≥15° after aTSA Does shoulder implant angle matter for recovery? A new review suggests maybe not
A systematic review and meta-analysis of 15 studies involving 1,190 shoulders found no clinically significant differences in patient-reporte…
After shoulder replacement, surgeons often worry about how the socket implant is angled.
Apr 2, 2026

Research across Arthritis

Related studies from across the Arthritis family.

Kinematic alignment improves function and pain over mechanical alignment in robotic TKA
Orthopedics & Sports Medicine Meta-analysis
Kinematic alignment improves function and pain over mechanical alignment in robotic TKA Kinematic alignment beats mechanical in knee replacement
This meta-analysis of 1470 patients undergoing robotic-assisted total knee arthroplasty found that kinematic alignment (KA) was superior to …
A new analysis suggests aligning the knee implant to a patient's natural anatomy may lead to less pain and better function after robotic kne…
Jun 1, 2026
Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function
Rheumatology Meta-analysis
Systematic review and meta-analysis of Wuqinxi for knee osteoarthritis joint function Wuqinxi exercise improves knee function and muscle strength in osteoarthritis patients
This systematic review and meta-analysis evaluated Wuqinxi (WQX) in patients with knee osteoarthritis. The analysis pooled data from 809 par…
A review of eight hundred and nine patients found that Wuqinxi exercise significantly improved knee function and muscle strength compared to…
Frontiers May 22, 2026
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
Physical Medicine & Rehab RCT
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis Hip replacement beats exercise for severe hip arthritis
This single-centre randomized controlled trial enrolled 120 patients with moderate-to-severe hip osteoarthritis (Kellgren-Lawrence grades 2 …
A new trial finds hip replacement plus rehab dramatically outperforms exercise alone for moderate-to-severe hip osteoarthritis.
May 1, 2026
Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response
Anesthesiology & Pain Medicine RCT
Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response New Gene Test Predicts Who Gets Pain Relief From Acupuncture
This randomized trial compared verum acupuncture, sham acupuncture, celecoxib, placebo, and waiting list in 180 patients with chronic knee p…
A new gene test might help doctors know if acupuncture will actually stop your knee pain before you start treatment.
Apr 30, 2026
Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
Allergy & Immunology Sys. Review
Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data Engineered Exosomes Could Change How We Treat Knee Pain
This narrative review examines the potential of engineered exosomes for treating knee osteoarthritis.
New engineered cell parts show promise for stopping knee arthritis damage in early tests before human trials.
Frontiers Apr 29, 2026
Feasibility Review of Portable Markerless Motion Capture for Knee OA
Orthopedics & Sports Medicine
Feasibility Review of Portable Markerless Motion Capture for Knee OA New tech brings knee pain insights to real-world settings
This review of a feasibility study involving 85 individuals with knee OA examined a portable markerless motion capture system.
Scientists are using smart cameras in community centers to see how knee osteoarthritis really affects movement, revealing new paths to perso…
medRxiv Apr 29, 2026
Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events
Rheumatology Meta-analysis
Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events Knee Pain Relief That Lasts? This Shot Could Be It
A systematic review and meta-analysis of nineteen randomized controlled trials evaluated intra-articular adipose-derived cell therapies for …
This new treatment could help people with stubborn knee pain finally walk without wincing.
Frontiers Apr 24, 2026
Observational transcriptomic analysis identifies genes associated with knee osteoarthritis severity in older adults
Genetics & Precision Medicine
Observational transcriptomic analysis identifies genes associated with knee osteoarthritis severity in older adults Knee Pain Could Start in Your Thigh Muscles, Study Says
This observational study analyzed vastus lateralis muscle RNA from 523 older adults with knee radiographs.
Scientists found specific genes in thigh muscles linked to knee arthritis severity.
medRxiv Apr 23, 2026
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program
Physical Medicine & Rehab Cohort
Structured rehabilitation reduced pain in hip or knee osteoarthritis patients in a Danish nationwide program Good News for Knee Pain: Your Therapist Choice May Not Matter
This observational cohort study evaluated a structured rehabilitation program delivered by trained healthcare professionals to adults with h…
A new study shows the rehab program matters more than the specific therapist treating you.
medRxiv Apr 21, 2026
Topical S. officinale preparations show efficacy for acute back pain, knee osteoarthritis, ankle sprains, and myalgia versus placebo
Drug Pipeline RCT
Topical S. officinale preparations show efficacy for acute back pain, knee osteoarthritis, ankle sprains, and myalgia versus placebo Comfrey’s Ancient Healing Power, Now Backed by Science
This review evaluated topical S. officinale preparations for conditions including acute back pain, knee osteoarthritis, ankle sprains, and m…
An ancient herb used for 2,000 years to heal wounds and broken bones now has science backing its ability to ease pain and speed recovery whe…
Frontiers Apr 18, 2026
7-Year Observational Study Abstract Links BMI and Alignment to Cartilage Loss in Knee Osteoarthritis
Orthopedics & Sports Medicine
7-Year Observational Study Abstract Links BMI and Alignment to Cartilage Loss in Knee Osteoarthritis Heavier Weight + Bow-Legged? Your Knees Are at Much Higher Risk
This 7-year observational study abstract involving 3,016 participants in the Osteoarthritis Initiative examined body mass index and lower li…
Carrying extra weight and having bow-legged knees together speed up cartilage loss much faster than either factor alone.
medRxiv Apr 18, 2026
Meta-analysis finds 87% implant survivorship after 10 years in patients under 50 undergoing TKA
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis finds 87% implant survivorship after 10 years in patients under 50 undergoing TKA Young Knee Pain Has a New Solution
This systematic review and meta-analysis examined 17,705 patients aged less than 50 years undergoing total knee arthroplasty (TKA) with a me…
Getting a new knee joint can give young adults the freedom to move again without pain.
Apr 15, 2026

Questions about Osteoarthritis

How long do knee implants last in patients under 50?

For patients under 50, knee implants (total knee arthroplasty) show 87% survival at 10+ years, with aseptic loosening as the main reason for revision.

Full answer →
Can engineered exosomes be used to treat osteoarthritis?

Yes, early research shows engineered exosomes can target cartilage, reduce inflammation, and promote repair in osteoarthritis, but human trials are still needed.

Full answer →
Which genes are linked to osteoarthritis in meniscus and cartilage?

Genes linked to osteoarthritis in meniscus and cartilage include 27 meniscus-specific, 28 shared, and 20 cartilage-specific causal genes, such as VEGFA and CLEC18A, identified through genomic analysis.

Full answer →
What role do exosomal non-coding RNAs play in osteoarthritis?

Exosomal non-coding RNAs regulate osteoarthritis by controlling inflammation, cartilage breakdown, and joint cell communication, and show promise as biomarkers and therapies.

Full answer →