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Home › Conditions › Overweight

Overweight

33 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Overweight

140 trials tracked for Overweight: 42 in phase 3 or 4 and 24 with published results. The most-cited published study has 6045 citations.

140Trials tracked
42Phase 3 & 4
0Recruiting
24With published results
Phase distribution
Phase 4 11 Phase 3 31 Phase 2 15 Phase 1 5 Other / NA 78
  1. Phase 4 The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS Completed · 6,045 cited
  2. Phase 3 Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity Completed · 4,362 cited
  3. Phase 3 STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity Completed · 1,279 cited
  4. Phase 3 Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity Completed · 1,262 cited
  5. Phase 3 Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program Completed · 989 cited
  6. Phase 3 Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity Completed · 861 cited
Show 44 more trials
  1. Phase 3 Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity Completed · 764 cited
  2. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight Completed · 664 cited
  3. Phase 3 A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity Completed · 618 cited
  4. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities Completed · 399 cited
  5. Phase 3 Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1) Completed · 371 cited
  6. Phase 3 Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach Completed · 264 cited
  7. Phase 4 A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors Completed · 263 cited
  8. Phase 4 Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes Completed · 242 cited
  9. Phase 3 Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD) Completed · 118 cited
  10. Phase 3 Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity. Completed · 111 cited
  11. Phase 3 A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obesity or Overweight (SURMOUNT-CN) Completed · 104 cited
  12. Phase 3 Targeting Inflammation Using Salsalate in CardioVascular Disease Completed · 61 cited
  13. Phase 3 Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range Completed · 60 cited
  14. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss Completed · 14 cited
  15. Phase 3 Low Level Laser Treatment (LLLT) and Lorcaserin for Weight Management Completed · 13 cited
  16. Phase 4 Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc Completed · 3 cited
  17. Phase 3 A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program Completed · 3 cited
  18. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight Completed · 1 cited
  19. Phase 4 Mechanisms of Weight Loss With SGLT2 Inhibition Completed
  20. Phase 4 Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers Completed
  21. Phase 4 Angiotensin II Blockade and Inflammation in Obesity Completed
  22. Phase 4 Effect of Calcium + Vitamin D Supplementation on Weight Management in Very-low Calcium Consumers Completed
  23. Phase 4 Exercise and Phytoestrogens: Effect on Factors Predisposing to Cardiovascular Disease(CVD) in Postmenopausal Women Completed
  24. Phase 4 Effect of Orlistat in Body Composition Completed
  25. Phase 4 Litramine in Weight Maintenance Completed
  26. Phase 3 Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function Completed
  27. Phase 3 A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range Completed
  28. Phase 3 Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension Completed
  29. Phase 3 A Safety and Efficacy Study of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Participating in an Intensive Behavior Modification Program Completed
  30. Phase 3 Effect of Vitamin D on Metabolic Profile in Overweight or Obese Women Completed
  31. Phase 3 A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects Completed
  32. Phase 3 Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects Completed
  33. Phase 3 A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects Completed
  34. Phase 3 Efficacy and Safety of IQP-VV-102 in Weight Management Completed
  35. Phase 3 Efficacy and Safety of Zenoctil in Reducing Body Weight Completed
  36. Phase 3 A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes Completed
  37. Phase 2 Trial of Leptin Administration After Roux-en-Y Gastric Bypass Completed
  38. Phase 2 A Study of LY3437943 in Participants Who Have Obesity or Are Overweight Completed
  39. Phase 2 Break It Up: A Study Evaluating Breaking Up Daily Sedentary Behavior in Youth Completed
  40. Phase 2 A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults Completed
  41. Phase 2 A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects Completed
  42. Phase 2 Inflammation, Polyphenols, and Genetics Completed
  43. Phase 2 A Study to Evaluate How VI-0521 Affect Psychomotor Performance in Healthy Overweight and Obese Subjects. Completed
  44. Phase 2 Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity. Completed

Showing the 50 most-cited and recently-updated of 140 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
GZR18 showed weight loss in Chinese adults with overweight or obesity in a phase 1b/2a trial
Diabetes & Endocrinology RCT
GZR18 showed weight loss in Chinese adults with overweight or obesity in a phase 1b/2a trial New Drug Cuts Weight by Nearly 20% in Just 35 Weeks
In this randomized, placebo-controlled phase 1b/2a trial, 60 Chinese adults with overweight or obesity received GZR18 or placebo.
This new treatment shows huge promise for helping people reach their weight goals without daily pills.
Apr 23, 2026
Tirzepatide MTD Demonstrates Cost-Effectiveness Versus Semaglutide MTD in Obesity Simulation Modeling Study
Diabetes & Endocrinology Phase III
Tirzepatide MTD Demonstrates Cost-Effectiveness Versus Semaglutide MTD in Obesity Simulation Modeling Study Tirzepatide Saves Money and Health Over Semaglutide
This simulation modeling study using Phase-3 trial data evaluated tirzepatide versus semaglutide in individuals with obesity or overweight w…
Imagine standing in a doctor's office, facing a choice between two powerful weight-loss medicines.
Apr 22, 2026
Meta-analysis links ultra-processed food intake to higher odds of adolescent overweight/obesity
Diabetes & Endocrinology Meta-analysis
Meta-analysis links ultra-processed food intake to higher odds of adolescent overweight/obesity High ultra-processed food intake linked to higher obesity risk in teens
This systematic review and meta-analysis synthesizes evidence on ultra-processed food consumption and overweight/obesity in adolescents.
Teens who eat lots of ultra-processed foods have 63% higher odds of being overweight or obese compared to those with lower intake.
Apr 16, 2026
Theory-informed behavioural intervention reduces ultra-processed food intake and weight in UK adults
Nutrition & Obesity Medicine RCT
Theory-informed behavioural intervention reduces ultra-processed food intake and weight in UK adults You Can Eat Better And Lose Weight By Swapping Foods
This exploratory single-arm pre-post study in 45 UK adults with overweight or obesity and habitual ultra-processed food (UPF) intake of at l…
A new plan to swap processed snacks for real food helps people lose weight and feel better.
medRxiv Apr 16, 2026
Network meta-analysis finds metabolic surgery superior to GLP-1 agonists for weight loss in obesity
Nutrition & Obesity Medicine Meta-analysis
Network meta-analysis finds metabolic surgery superior to GLP-1 agonists for weight loss in obesity Weight-Loss Surgery Still Leads, But a New Medication Closes the Gap
A network meta-analysis of 20,015 adults with overweight or obesity compared metabolic/bariatric surgery, GLP-1 receptor agonists, and lifes…
Weight-loss surgery still beats drugs overall, but the newest medication tirzepatide closes the gap enough to matter for people who can't ha…
Apr 14, 2026
Post-hoc analysis finds both continuous and intermittent calorie restriction reduce weight in type 2 diabetes
Nutrition & Obesity Medicine RCT
Post-hoc analysis finds both continuous and intermittent calorie restriction reduce weight in type 2 diabetes Two calorie-restricted diets helped people with type 2 diabetes lose weight in a small study
A post-hoc analysis of RCTs in 67 people with type 2 diabetes and overweight or obesity compared 3-month continuous vs.
Two calorie-restricted diets helped people with type 2 diabetes lose weight and reduce fat while gaining muscle in a new study.
Apr 13, 2026
Overweight status at diagnosis in Kuwaiti children with new-onset type 1 diabetes is associated with milder clinical presentation and lower HbA1c
Diabetes & Endocrinology Cohort
Overweight status at diagnosis in Kuwaiti children with new-onset type 1 diabetes is associated with milder clinical presentation and lower HbA1c Overweight Kids With Diabetes Have Milder Symptoms
This retrospective cohort study analyzed 1,265 children aged 14 years or younger newly diagnosed with type 1 diabetes in Kuwait.
Being overweight changes how type 1 diabetes starts in children, making the early stage look different and easier to manage initially.
Frontiers Apr 12, 2026
Full-fat dairy vs. low-fat dairy with energy restriction for weight and metabolic outcomes in adults with overweight/obesity
Nutrition & Obesity Medicine RCT
Full-fat dairy vs. low-fat dairy with energy restriction for weight and metabolic outcomes in adults with overweight/obesity Full-Fat Dairy May Help Your Heart, Even Without Weight Loss
A 12-week RCT in 74 adults with overweight or obesity compared three daily servings of full-fat dairy to a low-fat dairy energy restriction …
Adding three daily servings of full-fat dairy improved blood pressure and diet quality in adults with overweight, offering heart benefits ev…
Apr 11, 2026
Meta-analysis finds distinct neural activation patterns to food and monetary rewards in overweight/obesity
Nutrition & Obesity Medicine Meta-analysis
Meta-analysis finds distinct neural activation patterns to food and monetary rewards in overweight/obesity Brain scans reveal how food and money rewards differ in people with overweight or obesity
A meta-analysis of 26 fMRI studies (1065 participants) found individuals with overweight/obesity show both overlapping and distinct neural a…
Researchers analyzed brain scan data from over 1,000 people to see how brains respond to food and money rewards.
Apr 8, 2026
Cognitive training add-on to behavioral weight-loss intervention shows moderate BMI reductions at 6 months
Primary Care & Family Medicine RCT
Cognitive training add-on to behavioral weight-loss intervention shows moderate BMI reductions at 6 months Cognitive training added to weight loss program shows modest benefits in small trial
A randomized trial in 148 adults with excess weight found that adding comprehensive cognitive training to standard behavioral weight-loss in…
Adding mental exercises to a weight loss program helped adults lose more weight and lower their BMI compared to standard care alone.
Apr 8, 2026
Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
Diabetes & Endocrinology RCT
Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA Small study finds adding exercise to calorie restriction may reduce knee pain and inflammation
A 4-week RCT in 23 overweight/obese adults with knee osteoarthritis compared calorie restriction alone to restriction plus aerobic exercise.
Adding exercise to a calorie-reduced diet lowered knee pain and a specific inflammation marker in overweight people with knee osteoarthritis…
Apr 8, 2026
GLP-1RAs reduce MACE risk in Asian and White adults with diabetes or overweight
Nutrition & Obesity Medicine Meta-analysis
GLP-1RAs reduce MACE risk in Asian and White adults with diabetes or overweight Do heart benefits from diabetes drugs work equally well across different races?
A meta-analysis of 74,703 adults with type 2 diabetes or overweight/obesity found GLP-1RAs reduced MACE risk versus placebo.
Diabetes drugs protect hearts in Asian and White adults, but the benefit for Black adults remains unclear due to small study numbers.
Apr 8, 2026

Questions about Overweight

Did extending sleep duration change insulin sensitivity in people with overweight?

No, extending sleep by about 1 hour per night for 6 weeks did not change insulin sensitivity in people with overweight or obesity who were short sleepers.

Full answer →
Do wholegrain rye diets help with weight loss in overweight adults?

Wholegrain rye diets do not lead to significantly more weight loss than refined wheat diets in overweight adults, but they improve metabolic markers like inflammation and gut health.

Full answer →
Do stand-alone digital lifestyle interventions improve weight for adults with overweight?

Yes, stand-alone digital lifestyle interventions (fully automated apps or websites) lead to modest weight loss and improved dietary habits in adults with overweight or obesity, based on a 2026 meta-analysis.

Full answer →
How does tirzepatide compare to semaglutide for weight reduction in adults without diabetes?

Tirzepatide leads to greater weight loss than semaglutide in adults without diabetes, based on network meta-analyses and cohort studies.

Full answer →