Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
Stopping arthritis drugs before surgery may raise flare risk
This living systematic review evaluates perioperative management of conventional synthetic DMARDs in adults with rheumatoid arthritis, psori…
Low-certainty evidence suggests stopping certain arthritis drugs before surgery might increase the chance of a disease flare, but infection …
Meta-analysis of upadacitinib for rheumatoid arthritis finds similar efficacy for 15 mg and 30 mg doses
Upadacitinib improves rheumatoid arthritis symptoms in meta-analysis
This systematic review and meta-analysis of 5,237 participants with rheumatoid arthritis found that upadacitinib 15 mg and 30 mg significant…
A new analysis finds upadacitinib helps rheumatoid arthritis symptoms, but higher dose raises infection risk.
Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
Safer CD40/CD40L targeting needs selectivity for autoimmune diseases
This narrative review examines CD40/CD40L signaling regulation in rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome…
A narrative review suggests that safer therapeutic targeting of CD40/CD40L signaling will require greater selectivity to treat rheumatoid ar…
Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
A new enzyme target could treat many serious diseases at once
This narrative review synthesizes evidence on PAD4-mediated citrullination and PAD4-directed therapies for conditions including rheumatoid a…
A single enzyme called PAD4 helps cause many different diseases, and new medicines targeting it might finally help people with multiple cond…
Narrative review explores m6A modification and metabolic reprogramming in rheumatoid arthritis
Rheumatoid Arthritis May Start With a Tiny Chemical Tag on Your Genes
This narrative review examines the role of m6A modification in metabolic reprogramming during rheumatoid arthritis pathogenesis. The authors…
A hidden chemical switch in your cells may drive rheumatoid arthritis by turning on inflammation and joint damage.
Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
Autoimmune Disease May Fuel Heart Disease Through Shared Inflammation Pathway
This narrative review synthesizes evidence on pharmacological inhibition of peptidylarginine deiminase 4 and gasdermin pore formation in chr…
A new review explains why people with lupus and rheumatoid arthritis face higher heart risks and points to a shared inflammatory pathway tha…
Narrative review on multi-omics for spondyloarthritis and psoriatic arthritis
New multi-omics strategies help doctors better understand spondyloarthritis and psoriatic arthritis conditions
This narrative review synthesizes evidence on multi-omics strategies for spondyloarthritis and psoriatic arthritis. It argues that integrati…
Doctors are using advanced genetic and protein tests to study spondyloarthritis and psoriatic arthritis. These new methods help find better …
Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients
Rheumatoid Arthritis Patients Face Higher Shingles Risk Than General Public
This systematic review and meta-analysis synthesized data on herpes zoster risk in rheumatoid arthritis patients. The pooled proportion of h…
People with rheumatoid arthritis have a much higher chance of getting shingles, and doctors must watch for specific risk factors like high s…
Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
Plant Particles Quiet Joint Fire in Rheumatoid Arthritis Patients
This narrative review summarizes preclinical evidence on plant-derived extracellular vesicles (PDEVs) for rheumatoid arthritis. PDEVs show p…
• Tiny plant particles calm joint swelling and pain in lab tests • Helps RA patients tired of harsh drug side effects • Still years from pha…
FDA Approves Hadlima (adalimumab) for Multiple Inflammatory Indications
FDA approves Hadlima, a new biosimilar for several inflammatory diseases.
The FDA approved Hadlima (adalimumab) for several inflammatory conditions including rheumatoid arthritis, juvenile idiopathic arthritis, pso…
The FDA approved Hadlima (adalimumab) for treating conditions like rheumatoid arthritis, psoriasis, and Crohn's disease. It is a biosimilar,…
Telephone-delivered Walk With Ease program recruitment strategies compared in adults with arthritis
Radio ads and Facebook work best to recruit arthritis patients
This randomized trial in 267 adults with arthritis compared recruitment strategies for a telephone-delivered walking program. Facebook was t…
Radio ads and Facebook ads work best to get arthritis patients into walking programs, but the best method depends on who you are trying to r…
Meta-analysis of 38 rodent studies shows sinomenine reduces arthritis markers in preclinical models
Sinomenine reduces joint swelling and inflammation in arthritis mice
This systematic review and meta-analysis evaluates sinomenine in 38 rodent models of rheumatoid arthritis. The authors synthesize data on in…
A new review shows sinomenine stops joint swelling and protects bone in mice, but doctors still need to test it on humans.
Questions about Rheumatoid Arthritis
Did baricitinib work well for juvenile idiopathic arthritis eye inflammation?
Baricitinib showed limited effectiveness for treating eye inflammation in children with juvenile idiopathic arthritis who did not respond to other standard treatments.
Full answer →Can machine learning predict when juvenile idiopathic arthritis will go inactive?
Yes, machine learning models using registry data can predict inactive disease in juvenile idiopathic arthritis with about 70-76% accuracy, but they are not yet ready for routine clinical use.
Full answer →Can Hadlima be used to treat juvenile idiopathic arthritis?
Yes, Hadlima (adalimumab) is FDA-approved to treat moderately to severely active polyarticular juvenile idiopathic arthritis in patients aged 2 years and older.
Full answer →How does macrophage metabolism change in gouty arthritis patients?
In gouty arthritis, macrophages shift their energy use from oxidative phosphorylation to glycolysis and change from pro-inflammatory to anti-inflammatory states as the attack resolves.
Full answer →Does quercetin work for gouty arthritis based on recent reviews?
Recent reviews suggest quercetin has anti-inflammatory and antioxidant properties that could help with gout, but there is currently no strong clinical proof it works for gouty arthritis in humans.
Full answer →Why do current gouty arthritis models fail to match human disease?
Current gout models fail because they do not fully capture the complex metabolic changes in macrophages or the chronic, multi-factorial nature of human disease.
Full answer →How is Arthritis Awareness Month observed to highlight the condition's impact?
Arthritis Awareness Month is observed in May to bring attention to the condition and its impact on daily life.
Full answer →What percentage of U.S. adults with arthritis engage in physical activity?
About 67% of U.S. adults with arthritis engage in at least one type of physical activity, though many do not meet full health guidelines.
Full answer →All Rheumatoid Arthritis Articles
- Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
- Meta-analysis of upadacitinib for rheumatoid arthritis finds similar efficacy for 15 mg and 30 mg doses
- Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
- Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
- Narrative review explores m6A modification and metabolic reprogramming in rheumatoid arthritis
- Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
- Narrative review on multi-omics for spondyloarthritis and psoriatic arthritis
- Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients
- Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
- FDA Approves Hadlima (adalimumab) for Multiple Inflammatory Indications
- Telephone-delivered Walk With Ease program recruitment strategies compared in adults with arthritis
- Meta-analysis of 38 rodent studies shows sinomenine reduces arthritis markers in preclinical models
- Psoriatic arthritis linked to interstitial lung disease prevalence
- Targeted therapies for psoriasis and psoriatic arthritis significantly alter lipid profiles across diverse patient populations
- Systematic review explores the role of RNA methylation in autoimmune rheumatic diseases
- Narrative review of transposable element methylation in autoimmune diseases
- Team-based care with rheumatological specialist assistants improved patient satisfaction in seropositive rheumatoid arthritis flares
- Systematic review and meta-analysis of diagnostic algorithms for rheumatoid arthritis and juvenile idiopathic arthritis
- High-intensity exercise improves strength and aerobic capacity in rheumatoid arthritis patients compared to low-intensity exercise
- Late-onset rheumatoid arthritis shows higher DAS28 scores and lower remission rates compared to young-onset disease in a meta-analysis
- Systematic review and meta-analysis of supervised exercise for foot pain in rheumatoid arthritis
- Ixekizumab shows efficacy in children with enthesitis-related and juvenile psoriatic arthritis
- GWAS and Mendelian randomization link aging, rheumatoid arthritis, and herpes zoster via shared MHC signals
- Narrative review on macrophage metabolism in gouty arthritis and therapeutic gaps
- Nomogram Predicts Osteoporosis Risk in Rheumatoid Arthritis Patients
- Combined MSK US and machine learning model improves rheumatoid arthritis disease activity assessment
- Etanercept therapy alters monocyte subsets and improves DAS28-CRP in rheumatoid arthritis patients
- Multi-ancestral GWAS identifies 152 RA loci with improved polygenic risk scores for AFR and AMR populations
- Meta-analysis identifies genetic variants linked to inflammatory pathways in rheumatoid arthritis and axial spondyloarthritis
- Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions
- Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations
- Secukinumab improves skin response in Chinese patients with psoriatic arthritis
- Longitudinal ANA dynamics predict 12-month remission in 688 adults with rheumatoid arthritis
- Autoimmune Thyroiditis Prevalence Higher in Obese Women With PCOS in Retrospective Cohort Analysis
- Biological and clinical factors associated with peripheral neuropathy in rheumatoid arthritis cohort
- Machine learning models predict inactive disease in juvenile idiopathic arthritis using registry data
- FDA Approves Stelara (ustekinumab) for moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis
- FDA Approves Stelara (ustekinumab) for moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis
- Narrative review discusses transcriptomics and algorithms in rheumatoid arthritis care
- Narrative review explores multimodal approaches for autoimmune diseases including rheumatoid arthritis and Crohn's
- Baricitinib showed limited efficacy in pediatric JIA-uveitis patients refractory to methotrexate or biologics at week 24
- Systematic review examines IL-35 and IL-39 roles in rheumatoid arthritis pathophysiology and therapeutic potential
- Guselkumab Phase III trials validate 3VAS and 4VAS measures for psoriatic arthritis disease activity assessment
- Systematic review and meta-analysis finds CEUS comparable to MRI for synovitis detection
- Case report suggests grade 3 ICI-induced inflammatory arthritis may correlate with sustained response to tislelizumab in advanced head and neck carcinoma
- Natural and synthetic compounds suppress inflammasome activation in NLRP3-driven pathologies
- Systematic review of gouty arthritis models highlights limitations in reproducing human disease complexity
- Implementation of cliexa-RA digital platform improved patient experience and time efficiency for 300 rheumatoid arthritis patients
- Systematic review examines lipid-immune crosstalk and dyslipidemia in rheumatoid arthritis patients
- Review of quercetin in metabolic diseases shows promise but lacks clinical validation
- Systematic review links gut microbiota dysbiosis to CKD-MBD, RA, OA, and OP pathogenesis
- Interstitial lung disease reduces achievement of rheumatoid arthritis treatment goals over 24 months
- Biological DMARDs show marginal patient-reported outcome benefits over conventional therapy in early rheumatoid arthritis
- Hand massage improves grip strength and function in early RA patients in pilot trial
- Post-hoc analysis of RCTs and cohorts identifies predictors of remission in ACPA-positive early RA treated with abatacept plus methotrexate or methotrexate alone
- Cross-sectional study finds association between autoimmune thyroiditis and rheumatoid arthritis
- Phase 2 trial finds hydroxychloroquine does not prevent rheumatoid arthritis in at-risk individuals
- Occupational inhalant exposures associated with increased rheumatoid arthritis risk in meta-analysis
- Meta-analysis compares HAQ-DI, SF36-PF, and SF36-PCS for physical function in psoriatic arthritis trials
- Rheumatoid arthritis is associated with a 58% higher risk of COPD compared to the general population
- FPGS Gene Variants Linked to Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis
- Reduced anti-CXCR3 antibodies associated with systemic autoimmunity and atherosclerosis in cohort study
- Meta-analysis finds oral JAK inhibitors increase HDL and LDL cholesterol levels in patients from RCTs
- Arthritis affects 22.7% of U.S. adults, projected to reach 78.4 million by 2040
- Immune signatures precede and accompany subclinical joint inflammation in ACPA-positive individuals at high risk for RA
- Arthritis Awareness Month observed in May to highlight condition impact
- Southeastern US states show highest arthritis-related severe joint pain and inactivity
- National prevalence of arthritis and associated activity limitations in U.S. adults examined
- Report describes physical activity patterns among US adults with arthritis
- Survey describes arthritis prevalence by age and sex among US adults
- Nurse counseling improves pain, fatigue, and function in rheumatoid arthritis patients in small RCT
- Review Links Gut Dysbiosis to Immune Dysfunction in Rheumatoid Arthritis
- Report examines arthritis diagnosis among U.S. veterans, specific numbers not provided
- Phenotype-based pain management in RA patients shows improved outcomes in retrospective cohort
- Elevated neutrophil-to-lymphocyte ratio correlates with higher mortality in rheumatoid arthritis
- Menopausal hormone therapy associated with modestly increased rheumatoid arthritis risk in meta-analysis
- Meta-analysis finds nausea in 24% and abdominal pain in 20% of RA patients on methotrexate