ADHD and ASD polygenic risk scores correlate with antipsychotic responsiveness in schizophrenia postmortem brains
Genes for ADHD and Autism May Predict Schizophrenia Drug Response
This postmortem brain study in 24 patients with schizophrenia and 48 controls examined polygenic risk scores for ADHD and ASD. It found a su…
Genes tied to ADHD and autism may predict how well antipsychotic drugs work in schizophrenia patients.
Observational study identifies cortical organization and topological alterations in schizophrenia
New Brain Maps Show Two Distinct Types of Schizophrenia
This observational study abstract examines cortical organization and subtyping in 3,958 individuals with schizophrenia compared to 5,489 neu…
New brain scans reveal two distinct patterns in schizophrenia that could lead to better personalized care for patients with the condition.
Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients
Researchers report framework for psychosurgery in treatment-refractory cases
This narrative critical review synthesizes contemporary psychosurgery options for treatment-refractory psychiatric disorders. It proposes a …
A new framework proposes connectomic-guided psychosurgery for treatment-refractory OCD, depression, and related disorders, based on symptom …
Systematic review links CNTN6 gene to neurodevelopmental and mental disorders
This Brain Protein Might Explain Autism and Schizophrenia
This systematic review summarizes evidence on CNTN6 gene involvement in neurodevelopment and disease. Rodent studies show CNTN6 protein affe…
Scientists have identified a specific protein that helps wire the brain and may be linked to mental health conditions.
Paracingulate sulcus prevalence reduced in patients with catatonia compared to controls
New Brain Scan Clue Points to Catatonia Risk
This hospital-based cohort study compared the paracingulate sulcus (PCS) in 109 patients with catatonia, 323 non-catatonic psychiatric patie…
A new study links specific brain shapes to catatonia, offering hope for better understanding.
Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
Why Blood Tests Fail to Predict Mental Health
This UK Biobank cohort study examined how technical, demographic, behavioral, and temporal factors influence 29 blood biomarkers. Variance e…
Many doctors rely on blood work to check your physical health.
Transcriptomic analysis of DLPFC identifies five-gene model for schizophrenia diagnosis in small cohort
Five Genes Could Help Diagnose Schizophrenia Sooner
This cohort study with 9 SCZ patients and 14 controls utilized single-cell and bulk RNA-seq data to identify gene expression patterns in the…
Five genes linked to brain cell energy problems could help doctors spot schizophrenia earlier in life before clear symptoms appear.
Observational study links striatal dopamine changes to psychosis remission in schizophrenia patients
Brain chemistry drops as schizophrenia symptoms fade, but relapse risks remain unclear.
This observational study examined 18F-DOPA PET scans and clinical assessments in 28 patients with schizophrenia and 21 healthy controls. The…
A new look at brain scans shows dopamine storage falls when psychosis remits, yet patients who relapsed still showed different patterns than…
Observational study evaluates dynamic prediction model for clozapine initiation in Danish schizophrenia patients
Can we predict who needs clozapine soon? A new model says yes for many patients.
This observational research article evaluates a dynamic prediction model designed to forecast incident clozapine prescriptions within 365 da…
A new model predicts which schizophrenia patients need clozapine within a year, helping doctors start this life-saving treatment sooner for …
Elobixibat improved constipation in schizophrenia or depression patients during postmarketing surveillance in Japan.
New Hope for Constipation in Mental Health Patients
This postmarketing cohort study evaluated elobixibat in 105 patients with schizophrenia and 129 with depression in Japan. Defecation frequen…
A new drug helps millions with mental health conditions overcome severe constipation caused by their mood-stabilizing medications.
Cognitive Remediation Therapy Re-analysis Shows Benefit Over Treatment As Usual on Global Assessment Scale
When Patients Rank Treatment Success Differently Than Doctors
This re-analysis of a randomized controlled trial evaluated Cognitive Remediation Therapy versus treatment as usual among participants and s…
Patients and doctors value different treatment benefits, and letting patients help decide what counts as success can change how we understan…
Multimodal MRI Protocol to Study Interoception in Schizophrenia
How Schizophrenia Changes the Body’s Inner Signals
This is a protocol for a cross-sectional multimodal MRI study in 30 individuals with schizophrenia and 30 matched healthy controls. It outli…
Understanding how the brain reads the body could unlock new ways to treat the emotional struggles of schizophrenia.