Multi-omics data integration in Spanish psychiatric patients and controls
Scientists Are Building a Mental Health Database That Could Change Treatment Forever
This cohort study in Spain involved over 4,400 participants, including approximately 2,300 psychiatric patients and 2,100 controls. The rese…
This project could finally help doctors match the right treatment to the right patient, reducing the trial-and-error that many people face t…
Cohort study shows schizophrenia patients and siblings differ in gray matter volume compared to healthy controls.
Why Age Changes Brain Risk
This cohort study examined gray matter volume patterns in 31 schizophrenia patients, 62 healthy siblings, and 31 healthy controls. One-way A…
Age changes brain risk for schizophrenia siblings, as new findings show brain structure differs between those in their teens and those in th…
Meta-analysis finds gamma neuromodulation benefits in schizophrenia and major depressive disorder
Gamma neuromodulation showed symptom improvements in schizophrenia and depression in this review
This systematic review and meta-analysis synthesizes evidence on gamma neuromodulation for neuropsychiatric disorders. It reports moderate i…
Gamma neuromodulation improved positive and negative symptoms, anxiety, and thinking skills in schizophrenia while reducing depression in ma…
Pathway-partitioned schizophrenia polygenic risk scores associate with age of psychosis onset in multi-ancestry cohorts.
Why Schizophrenia Hits Some People Younger Than Others
This cohort study utilized harmonized North American and UK Biobank datasets to evaluate genome-wide and pathway-partitioned schizophrenia p…
Tiny blood vessel and brain wiring genes may shape when schizophrenia first appears, helping families understand why some young adults devel…
Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk.
Feeling Alone May Quietly Rewire Your Mental Health
This Mendelian randomization study investigated the causal relationship between loneliness and severe mental illness, including schizophreni…
Loneliness may directly raise the risk of schizophrenia and depression by changing body chemistry through inflammation, affecting millions o…
Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders.
Your Brain's Blueprint May Not Predict Mental Illness After All
This cross-trait analysis examined genetic loci shared between cortical surface area or thickness and various psychiatric conditions. Result…
Brain shape genes and mental illness genes often push in opposite directions, complicating hopes for using scans and DNA to predict conditio…
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia.
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Immuno-kynurenine shifts track cognitive change in antipsychotic-naive first-episode schizophrenia
New Brain Signals Show Why Early Treatment Works
A longitudinal observational study of antipsychotic-naive first-episode schizophrenia patients and healthy controls examined peripheral infl…
Early treatment for schizophrenia clears thinking fog by fixing brain chemistry and immune signals that cause mental confusion before scary …
Prochlorperazine Labeling: Indicated for Severe Nausea/Vomiting and Schizophrenia
The FDA approved a new injection to treat severe nausea and schizophrenia when pills cannot be taken.
FDA labeling for prochlorperazine lists two approved indications: control of severe nausea and vomiting and treatment of schizophrenia. The …
A new FDA-approved injection now treats severe nausea and schizophrenia when patients cannot take pills by mouth.
New NeuroMark SPECT template identified replicable perfusion networks in schizophrenia cohorts.
Can brain scans reveal hidden patterns in schizophrenia without needing new drugs?
This cohort study applied a new NeuroMark SPECT template using spatially constrained ICA to two large sample datasets and an independent sch…
A new brain scan method finds consistent blood flow patterns in schizophrenia, helping doctors understand the condition without relying on t…
C3 and C4 levels correlate with schizophrenia outcomes in a small cohort study
Your Immune System May Shape How Severe Schizophrenia Becomes
A cohort study of 39 patients with schizophrenia found that higher baseline peripheral complement C3 and C4 levels correlated with longer du…
Two immune proteins in the blood may be linked to how severe schizophrenia symptoms become and how long they go untreated.
MTHFR C677T polymorphism linked to elevated risk of schizophrenia and type 2 diabetes comorbidity in Han Chinese patients.
Gene variation linked to higher risk of schizophrenia and diabetes in Chinese patients
This observational cohort study examined Han Chinese patients with comorbid schizophrenia and type 2 diabetes mellitus alongside healthy con…
A specific gene variation linked to schizophrenia and diabetes may serve as a susceptibility factor for these conditions appearing together …