Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV.
When HIV and Depression Collide, Treatment Suffers
This systematic review and meta-analysis of 32 studies involving people living with HIV (PLWH) examined the impact of mental health-related …
When depression, trauma, and poverty pile onto HIV, people struggle more to take their meds and keep the virus in check.
Right unilateral and bitemporal ECT show similar symptom improvement in resistant schizophrenia
For resistant schizophrenia, does one electric shock method work better than another?
A small RCT of 17 patients with resistant schizophrenia found both right unilateral (RUS) and bitemporal (BTS) ECT techniques produced signi…
For resistant schizophrenia, both electric shock methods work equally well, but one uses less power and protects against mental slowing.
Aerobic exercise and cognitive stimulation show no significant between-group cognitive benefits in schizophrenia trial
Exercise and computer training showed mixed results for schizophrenia patients in this small study.
A 12-week randomized controlled trial in 58 patients with schizophrenia found no statistically significant between-group differences in gene…
Schizophrenia patients without any intervention worsened in thinking skills and quality of life over 12 weeks, while exercise and computer t…
Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors.
Does the right antipsychotic drug reduce violence in people with schizophrenia and conduct disorder?
This RCT evaluated clozapine, olanzapine, or haloperidol in 99 individuals with schizophrenia and assaultive behaviors. Reductions in assaul…
Clozapine reduced violent urges in schizophrenia patients even when their mental symptoms did not improve, suggesting a direct calming effec…
Plasma H2S levels rise with cognitive gains in schizophrenia patients on atypical antipsychotics
Could a chemical change in your blood explain why some schizophrenia treatments boost your brain power?
A prospective observational study of 25 schizophrenia patients with acute exacerbation found that two months of atypical antipsychotic treat…
Schizophrenia patients taking standard medicine saw their memory and focus improve as a specific blood chemical level rose alongside their r…
Corticolimbic Glutamate-Functional Connectivity Associations Found in Antipsychotic-Naive CHR-P Individuals
Could early brain changes in psychosis risk be linked to specific chemical connections?
An observational study of antipsychotic-naive clinical high-risk for psychosis (CHR-P) participants (n=22), healthy controls (n=23), and fir…
People at high risk for psychosis show weaker brain chemical connections before symptoms appear, unlike those who have already developed the…
Normative latent cognitive structure metrics delineate cognitive heterogeneity across schizophrenia liability spectrum in healthy controls, siblings, and patients.
Study finds cognitive changes in schizophrenia siblings before clinical symptoms appear
This observational study evaluated cognitive heterogeneity using a normative latent cognitive structure (N-LCS) in healthy controls, unaffec…
Cognitive changes in reasoning and processing speed appear in schizophrenia siblings before clinical symptoms show, offering early warning s…
Cohort study in Portuguese families finds co-segregation of serious mental illnesses and rare CHD2 variant
Do serious mental illnesses share family roots? A rare gene clue emerges.
An observational cohort study of 173 multiplex families from the Portuguese Island Collection found co-segregation of psychotic and mood dis…
A rare gene mutation linked to autism and schizophrenia may also explain why psychotic and mood disorders often appear together in families.
Meta-analysis links auditory hallucinations in schizophrenia to specific brain activity patterns and neurotransmitter systems
Brain activity patterns linked to hearing voices in schizophrenia, research review finds
A systematic review and meta-analysis of neuroimaging studies in schizophrenia patients with auditory verbal hallucinations found AVH associ…
Hearing voices in schizophrenia is linked to increased brain activity in hearing and language areas alongside decreased activity in sensorim…
Protocol published for trial testing tDCS plus cognitive training in schizophrenia
Researchers plan trial to test brain stimulation plus cognitive training for schizophrenia
A study protocol describes a future randomized controlled trial of 120 adults with stable schizophrenia. The trial will compare active tDCS …
A new trial plans to test if gentle brain stimulation combined with computer training improves thinking and memory for people with schizophr…
Antipsychotic exposure shows time-dependent associations with vocational recovery in schizophrenia cohort
Do antipsychotics help people with schizophrenia get back to work or school?
A Danish register-based cohort study of 65,630 individuals with incident schizophrenia spectrum disorders found antipsychotic exposure was a…
Antipsychotic medication use initially lowers work or school chances for schizophrenia patients but eventually shows a small positive link a…
Psychological interventions show minimal symptom benefit, no substance use effect in schizophrenia with SUD
Do current talk therapies help people with schizophrenia who also use substances?
A meta-analysis of 35 RCTs (3,831 participants) found psychological interventions for adults with schizophrenia and substance use disorders …
Nearly half of people with schizophrenia also use substances, yet current talk therapies show almost no benefit for reducing drug or alcohol…