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Psychiatry
Meta-analysis
Meta-analysis finds distinct hedonic deficits in schizophrenia and depression
How do depression and schizophrenia change how we look forward to things?
A meta-analysis of 1,464 participants found schizophrenia spectrum individuals reported less anticipated pleasure than controls (g = -0.22, …
People with depression expect less joy and more dread from the future, while those with schizophrenia expect less joy but feel the same drea…
Apr 3, 2026
Psychiatry
RCT
Active tDCS shows large effect on life engagement in schizophrenia outpatients versus sham
Can brain stimulation help people with schizophrenia feel more engaged with life?
A randomized controlled trial of 50 outpatients with schizophrenia found active tDCS (15 weekday sessions) produced significantly greater re…
Non-invasive brain stimulation helped people with schizophrenia feel more engaged in daily life, work, and relationships after 15 sessions.
Apr 3, 2026
Psychiatry
Meta-analysis
Meta-analysis finds mGluR modulators show no significant efficacy for schizophrenia symptoms
Study finds experimental schizophrenia drugs not more effective than current treatments
A meta-analysis of 10 RCTs involving 3715 participants with schizophrenia found that mGluR agonists and positive allosteric modulators (POMA…
New experimental drugs for schizophrenia did not improve symptoms better than current standard treatments and caused more side effects leadi…
Apr 2, 2026