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Home › Medications › ketamine

ketamine

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of ketamine

139 trials tracked of ketamine: 61 in phase 3 or 4 and 28 with published results. The most-cited published study has 600 citations.

139Trials tracked
61Phase 3 & 4
0Recruiting
28With published results
Phase distribution
Phase 4 46 Phase 3 15 Phase 2 41 Phase 1 10 Other / NA 27
  1. Phase 4 Research Study for Major Depressive Disorder: Investigation of Glutamate Medications Completed · 600 cited
  2. Phase 4 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed · 559 cited
  3. Phase 4 Ketamine in the Treatment of Suicidal Depression Completed · 428 cited
  4. Phase 4 Ketamine For Suicidal Ideation Completed · 297 cited
  5. Phase 3 ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) Completed · 262 cited
  6. Phase 3 Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD) Completed · 240 cited
Show 44 more trials
  1. Phase 4 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Completed · 163 cited
  2. Phase 3 Pain Reduction With Intranasal Medications for Extremity Injuries Completed · 116 cited
  3. Phase 4 Biomarker Assessment of Glutamatergic Target Engagement Completed · 104 cited
  4. Phase 4 Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery Completed · 95 cited
  5. Phase 4 Geriatric Ketamine for Pain Management Study Completed · 79 cited
  6. Phase 4 Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients Completed · 78 cited
  7. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 63 cited
  8. Phase 3 Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy Completed · 46 cited
  9. Phase 4 Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression Completed · 41 cited
  10. Phase 4 Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention Completed · 32 cited
  11. Phase 4 Ketamine and Propofol for Upper Endoscopy Completed · 29 cited
  12. Phase 4 Randomized Trial of Sedative Choice for Intubation Completed · 27 cited
  13. Phase 4 Ketamine Infusion for Adolescent Depression and Anxiety Completed · 20 cited
  14. Phase 4 The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Completed · 18 cited
  15. Phase 3 Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain Completed · 14 cited
  16. Phase 4 Ketamine for Older Adults Pilot Completed · 13 cited
  17. Phase 3 Ketamine for Treatment Resistant Late-Life Depression Completed · 12 cited
  18. Phase 4 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine Completed · 11 cited
  19. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  20. Phase 4 The Impact of Perioperative Ketamine Infusion on Surgical Recovery Completed · 7 cited
  21. Phase 3 Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda Completed · 7 cited
  22. Phase 3 Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial Completed · 5 cited
  23. Phase 4 NMDA Antagonists in Bipolar Depression Completed
  24. Phase 4 Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients Completed
  25. Phase 4 Ketamine For Acute Treatment of Pain in Emergency Department Completed
  26. Phase 4 A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion Completed
  27. Phase 4 Sub-dissociative Ketamine for the Management of Acute Pediatric Pain Completed
  28. Phase 4 Ketamine for Depression: An MRI Study Completed
  29. Phase 4 Ketamine Versus Etomidate for Rapid Sequence Intubation Completed
  30. Phase 4 Effect of Ketamine on Analgesia Post-Cardiac Surgery Completed
  31. Phase 4 Ketamine Effect After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study Completed
  32. Phase 4 A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD) Completed
  33. Phase 4 Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department Completed
  34. Phase 4 Ketamine vs Hydromorphone Completed
  35. Phase 4 Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department Completed
  36. Phase 4 Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation Completed
  37. Phase 4 Sub-dissociative Dose Ketamine Dosing Study Completed
  38. Phase 4 Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy Completed
  39. Phase 4 Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery Completed
  40. Phase 4 Ketamine Treatment Effects on Synaptic Plasticity in Depression Completed
  41. Phase 4 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Completed
  42. Phase 4 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Completed
  43. Phase 4 Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects Completed
  44. Phase 4 The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion Completed

Showing the 50 most-cited and recently-updated of 139 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ketamine shows cognitive effects in animal models but cognitive worsening in human Huntington's disease study
Neurology Meta-analysis
Ketamine shows cognitive effects in animal models but cognitive worsening in human Huntington's disease study Can ketamine help brain injuries? Animal studies say maybe, but human evidence is thin
A systematic review and meta-analysis of 22 studies (21 animal, 1 human) found ketamine showed positive cognitive effects in 93.2% of animal…
Animal studies suggest ketamine might help brain injuries, but the only human trial found it worsened thinking in patients with Huntington's…
Frontiers Apr 2, 2026
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients
Orthopedics & Sports Medicine RCT
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients Which drug works best for pain when positioning patients with broken hips?
A 75-patient RCT compared IV ketamine (0.3 mg/kg), IV dexmedetomidine (0.5 μg/kg), and femoral nerve block for analgesia during positioning …
Ketamine outperformed nerve blocks and dexmedetomidine for reducing severe pain when positioning patients with broken hips before surgery.
Apr 2, 2026
Intranasal ketamine shows similar pain relief to IV opioids for renal colic in ED meta-analysis
Anesthesiology & Pain Medicine Meta-analysis
Intranasal ketamine shows similar pain relief to IV opioids for renal colic in ED meta-analysis Intranasal ketamine and IV opioids show similar pain relief for kidney stones
A meta-analysis of 4 RCTs including 454 patients with renal colic found no significant differences in pain scores at 5, 15, or 30 minutes be…
Nasal ketamine and IV opioids provide equal pain relief for kidney stones, with no difference in side effects or need for extra medication.
Apr 2, 2026
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use
Psychiatry Phase IV
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use Could Ketamine Be the Key to Easing Pain and Healing Minds After Surgery?
This Phase 4 trial investigates ketamine's efficacy in reducing postoperative pain and opioid use in orthopedic trauma patients.
A new trial tests if giving ketamine during orthopedic surgery reduces pain, opioid needs, and symptoms of depression and PTSD compared to s…
CT.gov Mar 27, 2026