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Epilepsy

Subtypes of Epilepsy

Focal epilepsy 5 Developmental and Epileptic Encephalopathies 3 Partial-Onset Seizures 3 Dravet syndrome 2 Functional seizures 2 Infantile epileptic spasms syndrome 2 Nonconvulsive status epilepticus 2 Temporal lobe epilepsy 2 Epilepsy related to fever sensitivity 1 Epilepsy with myoclonic-atonic seizures 1 Generalized epilepsy 1 Generalized epilepsy with febrile seizures plus 1 Genetic epilepsy 1 Genetic generalised epilepsy 1 Mesial temporal lobe epilepsy 1 Multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2) 1 Neurodevelopmental disorder with epilepsy 1 PCDH19-related epilepsy 1 Primary Generalized Tonic-Clonic Seizures 1 Self-limited epilepsy with centrotemporal spikes 1 Juvenile myoclonic epilepsy 0

46 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Epilepsy

233 trials tracked for Epilepsy: 103 in phase 3 or 4 and 33 with published results. The most-cited published study has 1653 citations.

233Trials tracked

103Phase 3 & 4

0Recruiting

33With published results

Phase distribution

Phase 4 25 Phase 3 78 Phase 2 54 Phase 1 31 Other / NA 45

Phase 3 Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1) Completed · 1,653 cited
Phase 3 Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults Completed · 973 cited
Phase 4 RNS® System LTT Study Completed · 640 cited
Phase 3 Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study Completed · 636 cited
Phase 3 GWPCARE2 A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet Syndrome Completed · 261 cited
Phase 3 Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures Completed · 249 cited

Show 44 more trials

Phase 3 Brivaracetam Safety and Efficacy Follow-up Study in Subjects With Epilepsy Completed · 234 cited
Phase 3 Brivaracetam Efficacy and Safety Study in Subjects With Partial Onset Seizures Completed · 234 cited
Phase 3 Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures Completed · 228 cited
Phase 3 Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From Epilepsy Completed · 160 cited
Phase 3 Progesterone vs Placebo Therapy for Women With Epilepsy Completed · 156 cited
Phase 3 Effect of Brivaracetam (BRV) on Nonpsychotic Behavioral Side Effects in Subjects Treated Previously With Levetiracetam (LEV) Completed · 154 cited
Phase 3 An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromes Completed · 107 cited
Phase 3 A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults Completed · 82 cited
Phase 3 Study to Investigate Lacosamide as Add-on Therapy in Subjects ≥4 Years to <17 Years of Age With Partial Onset Seizures Completed · 62 cited
Phase 3 Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures. Completed · 40 cited
Phase 3 This Trial, Evaluating the Long-term Safety and Tolerability of Brivaracetam Will Provide Subjects Suffering From Epilepsy, Who May Have Benefited From Brivaracetam as Adjunctive Treatment, the Opportunity to Receive Open Label Brivaracetam Treatment Completed · 34 cited
Phase 4 Methylphenidate Treatment of Attention Deficits in Epilepsy Completed · 30 cited
Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset Seizures Completed · 25 cited
Phase 3 A Clinical Study to Investigate the Long-term Use of Lacosamide as Monotherapy in Subjects Who Completed Study SP0994 Completed · 25 cited
Phase 3 Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy Completed · 24 cited
Phase 3 Evaluation of Long-term Safety, and Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects With Epilepsy Completed · 24 cited
Phase 3 An Open-label, Multinational, Multicenter, Follow-up Study to Evaluate the Long-term Safety and Efficacy of Brivaracetam Completed · 24 cited
Phase 3 Follow-up Trial to Evaluate Long-term Safety and Efficacy of Brivaracetam in Subjects Suffering From Epilepsy Completed · 24 cited
Phase 3 Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic Therapy Completed · 22 cited
Phase 3 Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and Older Completed · 17 cited
Phase 3 Study to Evaluate the Safety and Efficacy of USL261 in Patients With Increased Bouts of Seizure Activity in the EMU Completed · 16 cited
Phase 3 Add on Lacosamide Versus High Dose Monotherapy Completed · 12 cited
Phase 3 Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy Completed · 9 cited
Phase 3 Study to Investigate Safety and Tolerability of Intravenous Lacosamide in Children. Completed · 7 cited
Phase 3 Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures Completed · 4 cited
Phase 3 A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization Completed
Phase 3 A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy Completed
Phase 4 BEEP Follow Up: Evaluation of Repeatability of Lamotrigine Pharmacokinetics in Epileptic Patients Completed
Phase 4 Comparison of the Cognitive and Behavioral Effects of Eslicarbazepine Acetate and Carbamazepine in Healthy Adults Completed
Phase 4 A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Completed
Phase 4 Trial Evaluating the Efficacy and Safety of Perampanel Added to Monotherapy in Participants With Partial Onset Seizures With or Without Secondary Generalization Completed
Phase 4 Anxiety and Depression in Epilepsy: A Treatment Study Completed
Phase 4 Lamotrigine Bioequivalence Completed
Phase 4 Use of Clobazam for Epilepsy and Anxiety Completed
Phase 4 Fycompa Titration Intervals and Effects on Retention Rate Completed
Phase 4 Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER). Completed
Phase 4 First Add-on vs. Mono-therapy Study of Topiramate in Neuro-Surgical Patients Completed
Phase 4 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients Completed
Phase 4 A Study to Assess Tolerability and Efficacy of Topiramate Monotherapy in Recently Diagnosed Patients With Epilepsy Completed
Phase 4 Comparative Study of Zonisamide and Carbamazepine as an Initial Monotherapy: Efficacy and Safety Evaluation Completed
Phase 4 Valproate Dose Reduction and Its Clinical Evaluation by Introducing Lamotrigine in Japanese Women With Epilepsy - Single Arm, Multicenter, and Open-label Study Completed
Phase 4 The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ Monotherapy Completed
Phase 4 Low and High Dose Zonisamide in Children as Monotherapy Completed
Phase 4 Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subjects With Newly or Recently Diagnosed Partial Epilepsy Completed

Showing the 50 most-cited and recently-updated of 233 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Questions about Epilepsy

Does prior brain surgery change how vagus nerve stimulation works?

Prior brain surgery for epilepsy does not appear to change how well vagus nerve stimulation works for drug-resistant epilepsy, based on real-world data.

Full answer →

Can deep learning detect focal cortical dysplasia in pediatric drug-resistant epilepsy?

Yes, deep learning models like MELD Graph and 3D-nnUNet can detect focal cortical dysplasia in pediatric drug-resistant epilepsy, with moderate accuracy and fewer false positives in MRI-negative cases.

Full answer →

How does vagus nerve stimulation work for drug-resistant epilepsy?

Vagus nerve stimulation (VNS) works by sending electrical impulses to the vagus nerve, which then modulates brain networks and neurotransmitters to reduce seizure frequency in drug-resistant epilepsy.

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Can heart rhythm tests predict seizures in children with epilepsy?

Heart rhythm tests like ECG can detect changes before some seizures, but they are not yet reliable enough to predict seizures in children with epilepsy.

Full answer →