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Home › Conditions › Hip Fracture

Hip Fracture

Subtypes of Hip Fracture

Femoral Neck Fracture 3 Proximal femoral fracture 2

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hip Fracture

31 trials tracked for Hip Fracture: 10 in phase 3 or 4 and 4 with published results. The most-cited published study has 95 citations.

31Trials tracked
10Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 7 Phase 3 3 Phase 2 5 Other / NA 16
  1. Phase 4 Randomized Controlled Trial for Exparel Hip Fracture Completed · 95 cited
  2. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 78 cited
  3. Phase 4 Comparative Study Between Levobupivacaine and Ropivacaine in the Hip Fractures of the Elderly Completed · 6 cited
  4. Phase 4 Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients Completed · 2 cited
  5. Phase 4 Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery? Completed
  6. Phase 4 Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients Completed
Show 25 more trials
  1. Phase 4 Does Omeprazole Decrease Intestinal Calcium Absorption? Completed
  2. Phase 4 A Randomised, Controlled Comparison of Vitamin D Strategies is Acute Hip Fracture Patients Completed
  3. Phase 3 Exercise and Testosterone Therapy in Elderly Men With Physical Frailty Completed
  4. Phase 3 Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population Completed
  5. Phase 2 Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery Completed
  6. Phase 2 Acute Hip Fracture Study in Patients 65 Years or Greater Completed
  7. Phase 2 Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement Completed
  8. Phase 2 Ultrasound-guided Femoral Nerve Blocks in Elderly Patients With Hip Fractures Completed
  9. Phase 2 Pilot Study of Atorvastatin for Orthopedic Surgery Patients Completed
  10. N/A Polyurethane Foam on the Sacrum for Prevention Completed
  11. N/A Surgical Treatment of Hip Fractures Under Peripheral Regional Anesthesia Completed
  12. N/A Variations in Anesthesia Care for Hip Fracture Surgery Completed
  13. N/A Optimizing Cerebral Autoregulation During Surgery Completed
  14. N/A Post-Operative Delirium in Elderly Surgical Patients Completed
  15. N/A Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures Completed
  16. N/A Role of Vacuum Assisted Closure (VAC) Device in Postoperative Management of Pelvic and Acetabular Fractures Completed
  17. N/A Mobilizing Evidence Into Action to Improve Outcomes of Vulnerable Seniors Completed
  18. N/A Validity and Reliability of Thai Version of Barthel Index for Hip Fracture Patients Completed
  19. N/A Vitamin D Levels in Frail Elderly Patients With a Hip Fracture Completed
  20. N/A Observational Clinical Study on Elderly Patients With Fracture of the Proximal Femur Treated With the Chimaera Nail Completed
  21. N/A Women's Health Initiative Strong and Healthy Study Completed
  22. N/A Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture Completed
  23. N/A Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Completed
  24. N/A A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia Completed
  25. N/A Body Weight Supported Treadmill Training Following Hip Fracture Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hip Fracture: what the trials found

For pain management after hip fracture surgery, local anesthetics such as Exparel 4 and levobupivacaine 5 have been studied, as well as intravenous fentanyl 6 and intravenous morphine 8. A phase 4 trial of IV morphine showed significant pain reduction at 30 minutes (p<.0001) and 60 minutes (p<.05) compared to comparators 8. Another trial reported a pain score change of 4 vs 2 with IV fentanyl 6.

Tranexamic acid (TXA) has been evaluated in multiple trials for reducing transfusion needs. One phase 4 trial found a lower mean number of units transfused (1.8 vs 1.2) 7, while a phase 3 trial showed no significant difference in transfusion rates (p=0.966) 12. Mortality was not significantly different (p=0.75) 7. The evidence on TXA's effect on transfusion is mixed.

Testosterone therapy was assessed in two phase 3 trials. One trial found a significant increase in total lean body mass (p=0.01) but no significant change in muscle strength 13. Another trial showed no significant improvement in six-minute walk distance (p=0.853) or lean body mass (p=0.336) 11. Thus, evidence for testosterone's functional benefit is conflicting.

Vitamin D2 supplementation was studied in a phase 4 trial, which reported functional outcomes including Timed Up and Go test and Two Minute Walk Test at 3 months, but no p-values were provided for comparison 10.

Recent results — preliminary, needs further review

  • A phase 2 trial of VK5211 showed significant improvement in efficacy in hip fracture patients confirmed by DXA scan (p=0.0032) 1.
  • A large trial of physical activity (N=49331) found no significant reduction in cardiovascular events (p=0.49) but significant improvement in physical function score (p<0.001) 2.
  • A trial of Chimaera short nail with telescopic cephalic screws reported 0% needing second surgery and functional scores of 4.11, 3.14, 1.73 3.
  • A trial of blood pressure management according to cerebral autoregulation found no significant differences in mean arterial pressure outside limits (p=0.60), estimated blood loss (p=0.60), or myocardial infarction (p=1.0) 18.

For the clinician treating this condition

  • For pain control, IV morphine and fentanyl are effective options; local anesthetics like Exparel and levobupivacaine are also available.
  • Tranexamic acid may reduce transfusion needs in some patients, but evidence is mixed; no mortality benefit was observed.
  • Testosterone therapy may increase lean body mass but does not consistently improve functional outcomes.
  • Recent evidence suggests VK5211 may improve bone density, and physical activity can enhance physical function without reducing cardiovascular events.

AI synthesis of 13 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
MMPro-HIP Model Improves Hip Fracture Risk Prediction Accuracy Compared to Global Machine Learning Model
Rheumatology Cohort
MMPro-HIP Model Improves Hip Fracture Risk Prediction Accuracy Compared to Global Machine Learning Model Smart System Helps Doctors Spot Hip Fracture Risks Early
This retrospective cohort study analyzed 1,287 elderly clinical records from Beijing Jishuitan Hospital.
A new artificial intelligence model predicts hip fracture risk in older adults even when doctors lack complete medical records.
Frontiers Apr 28, 2026
Systematic review and meta-analysis evaluates femoral neck system versus cannulated screws for Pauwels type III fractures
Drug Pipeline Meta-analysis
Systematic review and meta-analysis evaluates femoral neck system versus cannulated screws for Pauwels type III fractures Femoral Neck Fractures Heal Faster With New Implant
This systematic review and meta-analysis evaluated the Femoral Neck System (FNS) versus cannulated screws (CS) in 557 non-elderly adults wit…
A new hip implant helps young adults with severe fractures heal faster and avoid early surgery replacements compared to standard screws.
Frontiers Apr 18, 2026
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults
Orthopedics & Sports Medicine RCT
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults Can a single dose of methadone during hip surgery reduce painkiller needs?
In this randomized trial of 129 patients aged 60 or older undergoing hip fracture surgery, a single intraoperative dose of methadone (0.10 m…
A single methadone dose during hip surgery cuts early morphine use but keeps older patients in the hospital longer than those given a placeb…
Apr 17, 2026
3D printing-assisted one-stage THA with fixation for DDH and ipsilateral intertrochanteric fracture
Orthopedics & Sports Medicine Sys. Review
3D printing-assisted one-stage THA with fixation for DDH and ipsilateral intertrochanteric fracture 3D Print Helps Fix Broken Hip in Complex Case
This single-patient case report describes a 57-year-old female with Hartofilakidis type II developmental dysplasia of the hip (DDH) and an a…
A 3D-printed model helped a surgeon fix a complex broken hip and replace the joint in one surgery for a patient with a rare condition.
Frontiers Apr 17, 2026
Selective transfer via Collingwood Hip Fracture Rule reduced median travel distance for hip fracture patients in Ontario LTC
Orthopedics & Sports Medicine
Selective transfer via Collingwood Hip Fracture Rule reduced median travel distance for hip fracture patients in Ontario LTC Hip Fracture Patients Could Travel Less, But Not Everyone Wins
This retrospective cross-sectional analysis examined transport distances for Ontario long-term care residents with hip fractures.
A new map-based study shows that while direct transport saves time for broken hips, it creates a heavy burden for emergency crews in remote …
medRxiv Apr 14, 2026
Stroke survivors face substantially increased hip fracture incidence and elevated mortality compared to non-stroke populations
Geriatrics & Aging Sys. Review
Stroke survivors face substantially increased hip fracture incidence and elevated mortality compared to non-stroke populations Stroke Survivors Face High Risk of Broken Hips
This narrative review examines epidemiological and clinical interrelationships between stroke and hip fractures in stroke survivors over a 5…
A broken hip after a stroke is a dangerous double hit that kills faster and hurts more than in anyone else.
Frontiers Apr 9, 2026
Deep learning model detects and classifies femoral neck fractures with 93% accuracy in retrospective study
Rheumatology Cohort
Deep learning model detects and classifies femoral neck fractures with 93% accuracy in retrospective study AI model shows promise for detecting and classifying hip fractures on medical images
A retrospective multicenter diagnostic study of 806 patients from four Chinese hospitals evaluated a deep learning model for femoral neck fr…
A new AI tool helps doctors spot and classify hip fractures with over 93% accuracy, improving diagnostic skills for junior physicians.
Frontiers Apr 8, 2026
CVC catheters reduce puncture site leakage versus CPNB catheters for fascia iliaca block in elderly hip fracture surgery
Orthopedics & Sports Medicine RCT
CVC catheters reduce puncture site leakage versus CPNB catheters for fascia iliaca block in elderly hip fracture surgery For hip fracture pain relief, does the catheter type matter for leakage?
A 64-patient RCT in elderly patients undergoing hip fracture fixation compared single-lumen CVCs to CPNB catheters for continuous fascia ili…
After hip surgery, a common pain relief method involves a catheter that can leak at the skin.
Apr 3, 2026

Questions about Hip Fracture

What care strategies help older adults with hip fractures who also have memory problems?

For older adults with hip fracture and memory problems, key strategies include careful pain management, delirium prevention, early mobilization, and a team-based orthogeriatric approach.

Full answer →