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Hypertension

Subtypes of Hypertension

Pulmonary Arterial Hypertension 7 Pregnancy induced hypertension 5 Persistent Pulmonary Hypertension of the Newborn 2 Elevated blood pressure 1 Fulminant idiopathic intracranial hypertension 1 High-altitude pulmonary hypertension 1 Prehypertension 1 Pulmonary Hypertension Associated with Interstitial Lung Disease 1 Salt-sensitive hypertension 1 TBX4-associated pulmonary hypertension 1 Chronic Thromboembolic Pulmonary Hypertension 0 Grade I Hypertension 0 Post-capillary pulmonary hypertension 0 Pre-capillary pulmonary hypertension 0

122 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hypertension

928 trials tracked for Hypertension: 391 in phase 3 or 4 and 61 with published results. The most-cited published study has 1373 citations.

928Trials tracked
391Phase 3 & 4
0Recruiting
61With published results
Phase distribution
Phase 4 176 Phase 3 215 Phase 2 141 Phase 1 42 Other / NA 354
  1. Phase 3 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Completed · 1,373 cited
  2. Phase 3 Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE Completed · 603 cited
  3. Phase 3 Idiopathic Intracranial Hypertension Treatment Trial Completed · 538 cited
  4. Phase 4 Chronic Hypertension and Pregnancy (CHAP) Project Completed · 519 cited
  5. Phase 3 Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH Completed · 317 cited
  6. Phase 4 Stop Atherosclerosis in Native Diabetics Study Completed · 247 cited
Show 44 more trials
  1. Phase 4 Reducing Total Cardiovascular Risk in an Urban Community Completed · 192 cited
  2. Phase 4 A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis Completed · 167 cited
  3. Phase 4 Value of Liquid Potassium Magnesium Citrate in Controlling Hypertension Completed · 164 cited
  4. Phase 3 Diuretic Comparison Project Completed · 147 cited
  5. Phase 4 Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents Completed · 140 cited
  6. Phase 3 Comparing Safety and Efficacy of BOL-303259-X With Timolol Maleate in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed · 127 cited
  7. Phase 3 Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension Completed · 108 cited
  8. Phase 4 Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan Completed · 105 cited
  9. Phase 3 24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension Completed · 101 cited
  10. Phase 3 Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension Completed · 88 cited
  11. Phase 3 Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension Completed · 88 cited
  12. Phase 4 Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control Completed · 82 cited
  13. Phase 3 Long-Term Safety of Latanoprostene Bunod Ophthalmic Solution 0.024% in Japanese Subjects With OAG or OHT Completed · 79 cited
  14. Phase 4 Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension Completed · 77 cited
  15. Phase 4 Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF Completed · 71 cited
  16. Phase 3 Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed · 71 cited
  17. Phase 3 Randomized Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, 0.5% Completed · 61 cited
  18. Phase 3 Clinical Study to Evaluate the Antihypertensive Efficacy and Safety of Fimasartan in Hypertension Patients Completed · 60 cited
  19. Phase 3 Center of Research Translation (CORT) Project 2 Completed · 51 cited
  20. Phase 4 Mineralocorticoid Receptor (MR) Antagonist (Eplerenone) vs Amlodipine and STRIATIN Completed · 50 cited
  21. Phase 3 Tadalafil for Sarcoidosis Associated Pulmonary Hypertension Completed · 42 cited
  22. Phase 3 Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults Completed · 38 cited
  23. Phase 3 Efficacy and Safety of GMRx2 Compared to Dual Combinations for the Treatment of Hypertension Completed · 37 cited
  24. Phase 3 Efficacy and Safety of GMRx2 Compared to Placebo for the Treatment of Hypertension Completed · 32 cited
  25. Phase 3 Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension Completed · 29 cited
  26. Phase 4 Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure Completed · 26 cited
  27. Phase 3 Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension Completed · 24 cited
  28. Phase 4 Nebivolol and the Endothelin (ET)-1 System Completed · 23 cited
  29. Phase 3 A Study to Evaluate the Long-term Use of Valsartan in Children 6 Months to 5 Years Old With Hypertension Completed · 22 cited
  30. Phase 4 Study of Rhopressa® for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting Completed · 19 cited
  31. Phase 3 Olmesartan/HCTZ 40/12.5 mg Combination Therapy Versus Olmesartan Medoxomil 40 mg Monotherapy in Essential Hypertension Completed · 17 cited
  32. Phase 3 Clinical Study Comparing Two Models of a Travoprost Intraocular Implant Completed · 17 cited
  33. Phase 4 Targeting Right Ventricle in Pulmonary Hypertension Gilead Completed · 16 cited
  34. Phase 4 Targeting the Right Ventricle in Pulmonary Hypertension Completed · 16 cited
  35. Phase 3 24 Hour Ambulatory Cardiac Oxygen Consumption Completed · 16 cited
  36. Phase 3 Efficacy and Safety Study of Netarsudil 0.02% Ophthalmic Solution Compared to Ripasudil Hydrochloride Hydrate 0.4% Ophthalmic Solution in Japanese Subjects With Primary Open Angle Glaucoma or Ocular Hypertension Completed · 15 cited
  37. Phase 3 A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension Completed · 14 cited
  38. Phase 4 Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension Completed · 12 cited
  39. Phase 3 MK-0954E Study in Participants With Hypertension (MK-0954E-357) Completed · 12 cited
  40. Phase 3 Non-inferiority of PRO-122 Ophthalmic Solution vs KRYTANTEK Ofteno® in Glaucoma or Ocular Hypertension (CONFORTK) Completed · 12 cited
  41. Phase 4 Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients Completed · 11 cited
  42. Phase 3 A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension Completed · 11 cited
  43. Phase 3 Cardioprotective Benefits of Carvedilol-CR or Valsartan Added to Lisinopril Completed · 10 cited
  44. Phase 3 Evaluation of Safety of SPARC0913 in Open Angle Glaucoma or Ocular Hypertension Completed · 10 cited

Showing the 50 most-cited and recently-updated of 928 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Hypertension

Will having bilateral optic nerve sheath fenestration reduce my papilledema?

Bilateral optic nerve sheath fenestration is associated with significant improvement in papilledema and visual function for patients with idiopathic intracranial hypertension.

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Does optic nerve sheath fenestration improve vision for idiopathic intracranial hypertension?

Optic nerve sheath fenestration (ONSF) improves vision and reduces swelling in many patients with idiopathic intracranial hypertension, especially when other treatments fail.

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Can urgent venous sinus stenting help my fulminant idiopathic intracranial hypertension?

Urgent venous sinus stenting can rapidly improve vision and reduce pressure in fulminant idiopathic intracranial hypertension, but success depends on acting before permanent optic nerve damage occurs.

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Does one eye laser treatment lower pressure in the other eye for OHT?

Yes, unilateral selective laser trabeculoplasty (SLT) can lower IOP in the untreated eye, with a mean reduction of about 1.85 mmHg at 3-6 months.

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Do different regions have different rates of hypertension alongside hidradenitis suppurativa?

Yes, a systematic review found significant regional differences in hypertension rates among HS patients, with North America having higher odds than the Middle East/Asia.

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See all 5 questions about Hypertension →