Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery
This Common Memory Drug Cuts Opioid Use After Knee Replacement
A randomized controlled trial in adults with knee osteoarthritis found memantine did not significantly lower pain scores versus placebo, but…
A drug already approved for Alzheimer's disease may help knee replacement patients rely less on opioids during recovery — even if it does no…
Platelet-rich plasma therapy in knee osteoarthritis patients showed high prediction accuracy for pain reduction
Can a simple injection predict who gets real pain relief from knee treatment?
This retrospective cohort study evaluated 102 patients with knee osteoarthritis receiving platelet-rich plasma (PRP) therapy.
A new test can predict with over 90% accuracy which knee osteoarthritis patients will feel real pain relief from platelet-rich plasma inject…
Meta-analysis finds noninvasive electrical stimulation improves pain and function in knee osteoarthritis
Electric Stimulation Eases Knee Pain
A meta-analysis of 1,137 participants with knee osteoarthritis found that noninvasive electrical stimulation (NIES) demonstrated significant…
Safe electrical devices help older adults with knee pain move better and feel less pain without needing surgery.
CT-SMA improves trabecular estimation and OA diagnosis in knee osteoarthritis cohorts
The Hidden Bone Problem
This cohort study evaluated a CT-based Subchondral Microstructural Analysis (CT-SMA) method utilizing distillation learning technology in a …
A new method lets routine knee CT scans reveal hidden bone damage that usually requires expensive, hard-to-get MRI appointments.
Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysis
Otago Exercise Program Shows Promise for Recovery After Knee Replacement Surgery
A systematic review and meta-analysis of randomized controlled trials involving 1,088 patients undergoing total knee arthroplasty found that…
A structured exercise program may improve knee function and balance better than conventional rehab after knee replacement surgery, based on …
Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
Small study finds adding exercise to calorie restriction may reduce knee pain and inflammation
A 4-week RCT in 23 overweight/obese adults with knee osteoarthritis compared calorie restriction alone to restriction plus aerobic exercise.
Adding exercise to a calorie-reduced diet lowered knee pain and a specific inflammation marker in overweight people with knee osteoarthritis…
Deep learning reconstruction improves 5.0 Tesla knee MRI quality and diagnostic agreement in 69-patient cohort
Deep learning algorithm improves knee MRI image quality in small study
A prospective cohort study of 69 patients undergoing knee arthroscopy and 5.0 Tesla MRI found that deep learning-based reconstruction (DLR) …
A computer program using deep learning improved knee MRI image clarity by up to 350% compared to standard scans in a small study.
IPFP preservation versus resection in TKA shows no significant difference in 12-month KOOS scores
Study finds no clear benefit to preserving or removing knee fat pad during joint replacement
This RCT in patients undergoing TKA for knee osteoarthritis found no statistically significant difference in 12-month KOOS score improvement…
Whether to keep or remove the fat pad under your kneecap during knee replacement surgery makes no difference to your recovery or pain relief…
Pain catastrophizing predicts tDCS response patterns in knee osteoarthritis pain
Why does brain stimulation help some knee pain patients but not others?
A secondary analysis of 60 participants with knee osteoarthritis from a randomized trial used machine learning to identify predictors of res…
Knee pain patients who fear their pain the most often fail to benefit from brain stimulation therapy, while those with lower initial pain le…
Mobilization with movement reduces pain and disability in knee osteoarthritis meta-analysis
Mobilization therapy shows promise for reducing knee osteoarthritis pain and disability
A meta-analysis of 2 RCTs in individuals with knee osteoarthritis found mobilization with movement (MWM) significantly reduced pain (Hedges'…
A hands-on therapy called mobilization with movement significantly reduced pain and improved daily function for people with knee osteoarthri…
Sarcopenic obesity prevalence is 28% in adults with advanced knee OA and severe obesity
Sarcopenic obesity found in 28% of adults with severe knee osteoarthritis and obesity
A cross-sectional baseline analysis of a pilot RCT (n=50) found sarcopenic obesity prevalence was 28% among adults with advanced knee OA and…
Nearly one-third of adults with severe knee arthritis and obesity have low muscle mass, leading to worse walking distance, function, and qua…
Research across Arthritis
Related studies from across the Arthritis family.
Metabolic reprogramming of chondrocytes through impaired oxidative phosphorylation contributes to articular cartilage collapse
Cells' energy crisis may drive osteoarthritis cartilage collapse
This systematic review synthesizes literature regarding metabolic reprogramming in chondrocytes during osteoarthritis. The authors conclude …
Osteoarthritis may be fueled by a cellular energy crisis, not just wear and tear. A new review suggests targeting metabolism could lead to n…
Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies
Gut health may play a role in osteoarthritis joint pain
This narrative review synthesizes evidence linking gut microbiota dysbiosis to osteoarthritis. Human studies show OA-associated changes in m…
New research suggests that imbalances in gut bacteria could contribute to cartilage damage and inflammation in people with osteoarthritis.
Chronic ACL deficiency increases risk of moderate to severe arthritis compared to reconstruction
ACL injuries and surgery impact long term risk of arthritis
This meta-analysis of matched cohort studies evaluates the risk of osteoarthritis in patients with chronic anterior cruciate ligament (ACL) …
People with torn ACL ligaments face higher risks of severe joint arthritis over time, especially if they undergo certain surgical procedures…
Peripheral mechanisms like proton-sensing channels and neurovascular remodeling contribute to pain in osteoarthritis
New research explores why osteoarthritis pain becomes hard to treat
This narrative review explores the complex pathophysiology of osteoarthritis pain, highlighting roles such as proton-sensing nociceptor acti…
Pain from osteoarthritis may be driven by nerve changes and inflammation, making it harder for doctors to manage as the condition progresses…
Circadian misalignment associated with increased risk of osteoporosis, sarcopenia, and osteoarthritis
Circadian Disruption Linked to Bone and Muscle Loss
This narrative review examines the impact of circadian disruption on musculoskeletal health, specifically regarding bone loss, muscle protei…
Shift work and irregular eating may harm bones and muscles. A new review explains how.
NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
New review reveals how inflammation drives osteoarthritis joint damage
This narrative review synthesizes evidence on NF-κB signaling as a central hub integrating mechanical stress, innate immunity, and metabolic…
A new review explains how mechanical stress, immune signals, and metabolism combine to drive osteoarthritis, pointing to smarter treatments.
Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study
New cartilage score predicts knee osteoarthritis onset and progression in study cohorts
This observational cohort study in the Osteoarthritis Initiative found that the Cartilage Thickness Score was higher in individuals who late…
A new cartilage score predicts who will develop knee osteoarthritis or need a replacement before symptoms appear.
Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
Multi-omics approaches reveal new links between gut microbes and bone health
This narrative review synthesizes evidence that gut microbiome metabolites—SCFAs, bile acids, and tryptophan derivatives—regulate bone remod…
A narrative review suggests gut microbes may influence bone conditions like osteoporosis and osteoarthritis through specific metabolic pathw…
Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis
Curcumin shows promise for osteoarthritis pain with fewer side effects than NSAIDs
This umbrella review synthesizes evidence on curcumin formulations versus non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis.…
An umbrella review suggests curcumin may help osteoarthritis pain and function as well as NSAIDs while offering a more favorable tolerabilit…
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
Aging cells release signals that may worsen bone and joint disease in older adults
This narrative review examines the senescence-associated secretory phenotype (SASP) in aging populations with osteoarthritis, intervertebral…
A review suggests aging cell signals could drive bone and joint problems. This insight helps doctors understand why these conditions worsen …
Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models
Scientists found many plant chemicals that fight cancer and help diabetes in lab tests
This systematic review evaluates the bioactivity of 158 phenanthrene metabolites isolated from 53 Dendrobium taxa. The authors note that 64 …
A review of plant chemicals from Dendrobium plants shows strong activity against cancer and diabetes in lab studies. Most results come from …
Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
Olive Oil Compounds Ease Knee Pain Better Than Expected
This systematic review and meta-analysis evaluated orally and/or topically administered olive-derived extracts or isolated bioactive compoun…
• Olive compounds cut knee pain modestly in studies • Helps adults with osteoarthritis or degenerative joint pain • Only three small trials …
Questions about Knee Osteoarthritis
Will a structured rehabilitation program reduce pain in my hip or knee osteoarthritis?
Yes, structured rehabilitation programs like GLA:D reduce pain in hip or knee osteoarthritis, with over half of patients reporting significant improvement.
Full answer →Do intra-articular adipose-derived cell therapies reduce pain without causing serious side effects?
Yes, intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious side effects, based on a systematic review of 19 randomized trials.
Full answer →Are engineered exosomes currently an effective treatment for my knee osteoarthritis?
Engineered exosomes are not yet an effective treatment for knee osteoarthritis; they remain in preclinical research with no human efficacy data.
Full answer →