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Home › Conditions › Respiratory Failure

Respiratory Failure

Subtypes of Respiratory Failure

Airway Obstruction 3 Chronic hypercapnic respiratory failure 1 Nasal obstruction 1 Respiratory failure requiring mechanical ventilation 1

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Respiratory Failure

65 trials tracked for Respiratory Failure: 6 in phase 3 or 4 and 5 with published results. The most-cited published study has 117 citations.

65Trials tracked
6Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 3 Phase 3 3 Phase 2 9 Phase 1 2 Other / NA 48
  1. Phase 4 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed · 117 cited
  2. Phase 3 Astral VAPS AutoEPAP Clinical Trial Completed · 39 cited
  3. Phase 3 Heart And Lung Failure - Pediatric INsulin Titration Trial Completed · 25 cited
  4. Phase 4 Randomized Trial of Sedative Choice for Intubation Completed · 20 cited
  5. Phase 3 Self-management of Sedative Therapy by Ventilated Patients Completed · 4 cited
  6. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
Show 44 more trials
  1. Phase 2 Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection Completed
  2. Phase 2 Nebulized Hypertonic Saline for Mechanically Ventilated Children Completed
  3. Phase 2 Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients Completed
  4. Phase 2 Tenecteplase in Patients With COVID-19 Completed
  5. Phase 2 The Effect of Thiamine vs. Placebo on VO2 in Critical Illness Completed
  6. Phase 2 Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation Completed
  7. Phase 2 Vitamin D in Ventilated ICU Patients Completed
  8. Phase 2 Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure Completed
  9. Phase 2 Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Completed
  10. Phase 1 Novel Arm Restraint in the Intensive Care Unit Completed
  11. Phase 1 Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery Completed
  12. N/A DirEct Versus VIdeo LaryngosCopE Trial Completed
  13. N/A Extubation With or Without Spontaneous Breathing Trial Completed
  14. N/A Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure Completed
  15. N/A Efficiency of the King Vision Video Laryngoscope Completed
  16. N/A Mobile Critical Care Recovery Program for Acute Respiratory Failure Survivors Completed
  17. N/A Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines Completed
  18. N/A Protocolized Post-Extubation Respiratory Support Study Completed
  19. N/A Comparison Between Two Methods of Spontaneous Breathing Trial (SBT) Completed
  20. N/A Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure Completed
  21. N/A Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope Completed
  22. N/A Third International Study on Mechanical Ventilation Completed
  23. N/A The Emergency Department Sedation Pilot Trial Completed
  24. N/A Trilogy Comparison Study - Pediatrics Completed
  25. N/A Bougie Use in Emergency Airway Management Completed
  26. N/A Pragmatic Trial Examining Oxygenation Prior to Intubation Completed
  27. N/A Treatment of Critical Illness Polyneuromyopathy Completed
  28. N/A Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study Completed
  29. N/A Novel Non-Invasive Monitoring Parameter in a Hospital Setting Completed
  30. N/A Sleep and Circadian Rhythms in Mechanically Ventilated Patients Completed
  31. N/A Mode Of Ventilation During Critical IllnEss Pilot Trial Completed
  32. N/A Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients Completed
  33. N/A Assessing Ventilator Safety in Patients on Pressure-Support Ventilation Completed
  34. N/A Multi-center Evaluation of the NEMO Gauge to Aid in Correct Positioning of the Endotracheal Tube Completed
  35. N/A Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation Completed
  36. N/A Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis Completed
  37. N/A Performance of Baccalaureate Nursing Students in Insertion of Laryngeal Mask: a Trial in Mannequins Completed
  38. N/A Diaphragm Ultrasound Vs Transpulmonary Pressure To Set PEEP in ARDS Completed
  39. N/A Metabolites of Tramadol in the Postoperative Surgical Patients Completed
  40. N/A Electrical Stimulation in Patients With Prolonged Mechanical Ventilation Completed
  41. N/A External Nasal Dilator and Oxygen Therapy in Respiratory Failure Completed
  42. N/A A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU Completed
  43. N/A Pragmatic Investigation of optimaL Oxygen Targets Trial Completed
  44. N/A Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness Completed

Showing the 50 most-cited and recently-updated of 65 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Residential Ammonia Gas Release Leads to Emergency Visits and Hospitalizations
Pulmonology & Critical Care
Residential Ammonia Gas Release Leads to Emergency Visits and Hospitalizations Residential ammonia gas leak leads to hospital visits and respiratory cases
A case report describes an accidental residential-area anhydrous ammonia gas release affecting an unspecified number of people.
An accidental ammonia gas leak in a residential area caused multiple emergency visits, hospitalizations, and serious respiratory failure in …
CDC Apr 4, 2026
Case report identifies MTM1 mutation in neonate with X-linked centronuclear myopathy
Pediatrics Sys. Review
Case report identifies MTM1 mutation in neonate with X-linked centronuclear myopathy What happens when a newborn can't breathe? A rare muscle disease story
A case report and literature review describes a male neonate with severe hypotonia and respiratory failure.
A newborn boy born unable to breathe died from a rare muscle disease linked to a family history of similar tragic losses.
Frontiers Apr 2, 2026
Inspiratory muscle training shows no clear effect on physical function in critically ill adults on mechanical ventilation
Emergency Medicine Meta-analysis
Inspiratory muscle training shows no clear effect on physical function in critically ill adults on mechanical ventilation Breathing muscle training shows uncertain effect on physical function in ICU patients
A systematic review and meta-analysis of 18 studies in adults requiring invasive mechanical ventilation for ≥24 hours found inspiratory musc…
Breathing muscle training for ICU patients on ventilators may not improve their ability to move and perform daily activities, with effects r…
Apr 2, 2026

Questions about Respiratory Failure

Does continuous monitoring of heart rate and oxygen saturation help premature infants with respiratory problems?

Yes, continuous monitoring of heart rate and oxygen saturation is standard for premature infants with respiratory problems, as it helps detect deterioration early and guide treatment.

Full answer →
What causes respiratory failure in a male neonate with X-linked centronuclear myopathy?

Respiratory failure in a male neonate with X-linked centronuclear myopathy is caused by severe muscle weakness from MTM1 gene mutations, leading to inadequate breathing and ventilator dependence.

Full answer →