PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease
An Old Drug Class May Protect the Brain From Silent Damage
This systematic review and meta-analysis evaluated phosphodiesterase-5 inhibitors (sildenafil or tadalafil) versus placebo in 236 adults wit…
Drugs already approved for other conditions may help restore blood flow in a part of the brain that quietly fuels strokes and dementia.
Dementia prevention class shows no effect on dementia onset or insurance certification in observational study
Dementia prevention classes improved function but did not stop disease onset in this study
A retrospective observational study of 578 individuals with mild cognitive decline in three municipalities found no significant association …
Dementia prevention classes improved daily skills and function but did not stop disease onset or reduce long-term care needs in this study.
Occupational noise exposure linked to cognitive decline in cross-sectional study of 170 workers
Loud Job Sites May Be Costing Workers More Than Hearing
A cross-sectional study of 170 noise-exposed workers found hearing loss was significantly associated with cognitive decline.
Hearing protection on a noisy worksite may shield not only your ears but also how sharply your brain works in the years ahead.
BP variability and pulse pressure associated with cognitive decline in type 2 diabetes patients
Blood pressure swings linked to thinking problems in people with type 2 diabetes
A secondary analysis of 9,586 patients with type 2 diabetes from the ADVANCE trial found that higher blood pressure variability and baseline…
For people with type 2 diabetes, big swings in blood pressure are linked to a higher risk of memory and thinking problems down the road.
Social isolation linked to health risks in empty-nest older adults, integrative review finds
How does social isolation affect older adults whose children have moved out?
An integrative review of 14 studies found social isolation among empty-nest older adults over 60 is associated with elevated physical health…
For older adults whose children have moved out, feeling socially isolated is linked to higher risks of death, depression, loneliness, and a …
Research across Cognitive Dysfunction
Related studies from across the Cognitive Dysfunction family.
Luteolin monotherapy improves cognitive and memory impairments in rodent models of Alzheimer disease
Luteolin may improve memory and brain health in rodent models
This meta-analysis of preclinical rodent models indicates that luteolin monotherapy significantly ameliorates cognitive and memory impairmen…
A review of research suggests the compound luteolin could protect memory and reduce brain inflammation in models of Alzheimer's disease.
Electroacupuncture provides short-term improvements in MoCA and MMSE scores for MCI and early Alzheimer's
Electroacupuncture shows short term improvements for early Alzheimer's symptoms
This meta-analysis of 614 patients with Mild Cognitive Impairment and early Alzheimer's Disease found that electroacupuncture led to short-t…
Electroacupuncture may improve cognitive scores and reduce inflammation markers in people with early Alzheimer's and mild cognitive impairme…
Mind-body exercise improves global cognition and processing speed in older adults with mild cognitive impairment
Mind Body Exercise May Improve Cognition in Older Adults
This meta-analysis of 2034 older adults with mild cognitive impairment found that mind-body exercise significantly improves global cognition…
Mind body exercises may improve memory and processing speed for older adults with mild cognitive impairment, according to a large meta-analy…
Resistance training shows largest effect for global cognition in Alzheimer's and Parkinson's disease
Resistance training shows strongest results for cognitive health in dementia
This network meta-analysis of 1,993 participants evaluated six exercise modalities for global cognitive function in Alzheimer's disease, Par…
Resistance training may offer the strongest boost to cognitive function for people living with Alzheimer's or Parkinson's disease.
Scoping review protocol to map living arrangement and carer variables in dementia help-seeking research
Mapping How Living Arrangements Affect Help Seeking for Dementia
This is a scoping review protocol, not a completed study, that will map how living arrangement and supporter or carer related variables are …
New research plans to map how living situations and family support impact how people with memory problems seek a diagnosis for dementia.
Elevated plasma CD147 levels are associated with 1.75 odds ratio for poststroke cognitive impairment
Higher CD147 levels linked to cognitive issues after stroke
This observational study of 612 patients with ischemic stroke found that elevated plasma CD147 levels were associated with a 1.75 odds ratio…
A new look at stroke recovery shows that higher levels of a specific protein in the blood may signal a higher risk of lasting brain fog.
Remimazolam may reduce early postoperative cognitive dysfunction risk and intraoperative opioid consumption in elderly patients
Remimazolam May Reduce Early Cognitive Risks After Surgery
This meta-analysis of 2,226 elderly surgical patients evaluated remimazolam compared to other sedatives. The analysis found that remimazolam…
A new sedative may help protect elderly patients from early cognitive issues after surgery while reducing the need for other pain medication…
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Higher adherence to MedDiet and DASH associated with better executive function in aging populations
Mediterranean and DASH diets linked to better brain health
This meta-analysis of 8 longitudinal cohorts involving 17,368 individuals in Europe and the United States found that higher adherence to the…
Specific dietary patterns like the Mediterranean and DASH diets may help protect memory and mental focus as people age.
Combined physical and cognitive interventions improve global cognitive function and gait speed in frail older adults
Combined physical and cognitive exercise helps frail older adults
This meta-analysis of randomized controlled trials involving 989 participants found that combined physical and cognitive interventions signi…
A combined program of physical and cognitive exercises can improve memory and mobility for frail older adults while reducing signs of frailt…
Dysregulated tryptophan metabolism drives neurocognitive complications in approximately 40% of patients with chronic kidney disease
Tryptophan metabolism may link kidney disease to brain fog
This narrative review explores how dysregulated tryptophan metabolism, including kynurenine and indole pathways, contributes to cognitive im…
About 40% of people with chronic kidney disease experience cognitive issues, potentially linked to how the body processes a nutrient called …
Dexmedetomidine plus esketamine may reduce postoperative delirium and injury
Combined dexmedetomidine and esketamine may protect brain function after surgery
Perioperative combo of dexmedetomidine and esketamine lowers neuronal injury biomarkers and delirium risk in surgical patients.
A new analysis suggests a combination of two medications could lower the risk of confusion and protect brain health during and after surgery…
Questions about Cognitive Decline
Do cardiovascular conditions like stroke impact cognitive decline?
Yes, cardiovascular conditions like stroke, heart failure, and atrial fibrillation are linked to increased risk of cognitive decline through shared mechanisms like inflammation and reduced blood flow.
Full answer →Is blood pressure variability a risk for cognitive decline in diabetes?
Yes, blood pressure variability is linked to higher risk of cognitive decline in people with type 2 diabetes, independent of average blood pressure levels.
Full answer →Does social isolation in empty-nest adults increase health risks?
Social isolation in empty-nest adults is linked to higher risks of death, depression, and cognitive decline, though living alone by itself does not necessarily cause dementia.
Full answer →How does occupational noise exposure affect my cognitive decline?
Yes, occupational noise exposure is linked to faster cognitive decline, likely through hearing loss and brain changes, but more research is needed.
Full answer →Does living alone increase my risk of developing dementia?
Research is mixed: some studies link living alone to subjective cognitive decline, but a large French study found no direct link to dementia, though it did increase risk of institutionalization.
Full answer →