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Home › Conditions › Depressive Symptoms

Depressive Symptoms

Part of Depression

14 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Depressive Symptoms

113 trials tracked for Depressive Symptoms: 15 in phase 3 or 4 and 5 with published results. The most-cited published study has 213 citations.

113Trials tracked
15Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 4 Phase 3 11 Phase 2 19 Phase 1 4 Other / NA 75
  1. Phase 4 Research Evaluating the Value of Augmenting Medication With Psychotherapy Completed · 213 cited
  2. Phase 4 A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise Completed · 44 cited
  3. Phase 3 A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial Completed · 20 cited
  4. Phase 3 Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) Completed · 13 cited
  5. Phase 3 Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress Completed · 7 cited
  6. Phase 4 Memantine Augmentation of Antidepressants Completed
Show 44 more trials
  1. Phase 4 Effectiveness of Antidepressant Treatment for Depression in People With Parkinson's Disease Completed
  2. Phase 3 Buprenorphine for Treatment Resistant Depression Completed
  3. Phase 3 A Study of Duloxetine (LY248686) in Japanese Children and Adolescents With Depressive Disorder Completed
  4. Phase 3 Study In Patients With Depression Not Responding to Selective Serotonin Re-uptake Inhibitors Completed
  5. Phase 3 Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial) Completed
  6. Phase 3 Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial) Completed
  7. Phase 3 Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Women Completed
  8. Phase 3 Controlled-release Paroxetine in Major Depressive Disorder (Double-blind, Placebo-controlled Study) Completed
  9. Phase 3 Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women Completed
  10. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  11. Phase 2 Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas Completed
  12. Phase 2 Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD) Completed
  13. Phase 2 Study Of 323U66 SR In Major Depressive Disorder Completed
  14. Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
  15. Phase 2 Psychopharmacology of Psilocybin in Cancer Patients Completed
  16. Phase 2 eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients Completed
  17. Phase 2 An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress Completed
  18. Phase 2 Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED) Completed
  19. Phase 2 MDD POC Study GSK372475 Subjects Depressive Disease Completed
  20. Phase 2 Depressed Mood Improvement Through Nicotine Dosing 2 Completed
  21. Phase 2 eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk Completed
  22. Phase 2 Safety and Efficacy Study in Patients With Major Depressive Disorder Completed
  23. Phase 2 Electroacupuncture for Major Depression Completed
  24. Phase 2 An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression Completed
  25. Phase 2 Study to Treat Major Depressive Disorder With a New Medication Completed
  26. Phase 2 Pharmacokinetics and Tolerability of Vortioxetine (Lu AA21004) in Child and Adolescent Patients With Depressive or Anxiety Disorder Completed
  27. Phase 2 Beating the Blues for Your Heart Completed
  28. Phase 2 Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans Completed
  29. Phase 1 Paxil CR Bioequivalence Study Brazil - Fed Administration Completed
  30. Phase 1 TAK-653 Escalating Single and Multiple Dose Study in Healthy Participants Completed
  31. Phase 1 Paxil CR Bioequivalence Study Brazil Completed
  32. Phase 1 Nonconvulsive Electrotherapy: a Proof-of-concept Trial Completed
  33. N/A Southwest Hub for American Indian Youth Suicide Prevention Research Completed
  34. N/A Depression and ART Adherence in HIV+ Latinos Completed
  35. N/A ABSORB (Amount of Blueberries So Older Adults Reap Benefits) Completed
  36. N/A Piloting +Connection is Medicine / The Healing Spirits Program Completed
  37. N/A Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity Completed
  38. N/A Self-guided Treatment for Adolescents Navigating Depression Completed
  39. N/A Internet Cognitive Behavioural Therapy to Patients With Heart Failure and Depression Completed
  40. N/A College Student Stress: Transitions Over Time Completed
  41. N/A Berries, Bugs, and the Blues Completed
  42. N/A Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD) Completed
  43. N/A EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy Completed
  44. N/A Efficacy Testing of a Culturally Relevant Stigma Intervention With WLWH in Tanzania Completed

Showing the 50 most-cited and recently-updated of 113 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Dance interventions improve quality of life and reduce depressive symptoms in breast cancer survivors
Oncology Meta-analysis
Dance interventions improve quality of life and reduce depressive symptoms in breast cancer survivors Dance programs may improve quality of life for women with breast cancer
A meta-analysis of 12 RCTs in women with breast cancer found dance interventions significantly improved quality of life (SMD=0.62) and reduc…
A review of 12 studies found that dance interventions significantly improved quality of life and reduced depressive symptoms for women with …
Apr 2, 2026
Group Metacognitive Therapy Shows Large Symptom Reductions in Students with Anxiety
Psychiatry
Group Metacognitive Therapy Shows Large Symptom Reductions in Students with Anxiety Group therapy for student anxiety shows promising results in small, early study
An uncontrolled pre-post study of students with anxiety disorders or elevated symptoms found group Metacognitive Therapy (gMCT) delivered in…
Group therapy for student anxiety showed large symptom reductions and lasting benefits in an early study at a university clinic in Oslo.
Frontiers Apr 1, 2026

Research across Depression

Related studies from across the Depression family.

Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
Psychiatry Cohort
Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort Brain Scans Show Hidden Signals in Mental Health
A cohort study of 47,495 UK Biobank participants found plasma neurofilament light chain (NfL) levels were higher in bipolar disorder (d=0.20…
Blood tests now reveal hidden brain signals that distinguish depression from anxiety, offering clearer paths to the right treatment for mill…
medRxiv Apr 14, 2026

Questions about Depressive Symptoms

Can an AI CBT chatbot reduce anxiety and depressive symptoms in Brazilian patients?

Yes, a 2024 Brazilian study found that access to an AI CBT chatbot significantly reduced anxiety and depressive symptoms in primary care patients.

Full answer →
Do GP psychoeducation sessions help reduce depressive symptoms in primary care patients?

GP psychoeducation sessions did not significantly reduce depressive symptoms in primary care patients, though they improved depression knowledge and patient activation.

Full answer →
Do polygenic scores show effects on child depressive symptoms during adolescence?

Yes, polygenic scores for major depressive disorder show adolescence-specific effects on child depressive symptoms, as found in a Norwegian cohort study.

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How does frailty affect the prevalence of depressive symptoms in adults with cancer?

Frailty significantly increases the odds of depressive symptoms in adults with cancer, with a meta-analysis showing over five times higher odds compared to non-frail patients.

Full answer →