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Home › Conditions › Opioid Use Disorder

Opioid Use Disorder

Subtypes of Opioid Use Disorder

Opioid Overdose 8 Opioid dependence 2 Opioid Addiction 1 Prescription Opioid Misuse 0

27 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Opioid Use Disorder

202 trials tracked for Opioid Use Disorder: 45 in phase 3 or 4 and 23 with published results. The most-cited published study has 171 citations.

202Trials tracked
45Phase 3 & 4
0Recruiting
23With published results
Phase distribution
Phase 4 26 Phase 3 19 Phase 2 19 Phase 1 18 Other / NA 120
  1. Phase 3 Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain Completed · 171 cited
  2. Phase 3 Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder Completed · 113 cited
  3. Phase 3 Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study Completed · 60 cited
  4. Phase 3 Does a Non-Opioid Multimodal Pain (NOMO) Protocol Decrease Narcotic Use Completed · 50 cited
  5. Phase 3 Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension) Completed · 49 cited
  6. Phase 4 Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment Completed · 48 cited
Show 44 more trials
  1. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 28 cited
  2. Phase 4 Pain Control Following Sinus Surgery Completed · 20 cited
  3. Phase 4 SUBLOCADE Rapid Initiation Study Completed · 16 cited
  4. Phase 3 Open-Label Treatment Extension Study Completed · 13 cited
  5. Phase 3 Safety and Tolerability Study of Depot Buprenorphine in Treatment Seeking Subjects With Opioid Use Disorder Completed · 13 cited
  6. Phase 3 Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up Completed · 13 cited
  7. Phase 4 Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control Completed · 11 cited
  8. Phase 3 Opioid Prescription After Cesarean Trial Completed · 11 cited
  9. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  10. Phase 4 Evaluation of Buprenorphine Extended-Release Subcutaneous Injection at Alternative Injection Locations Completed · 8 cited
  11. Phase 3 Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL Completed · 8 cited
  12. Phase 4 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery Completed · 7 cited
  13. Phase 4 The Impact of Perioperative Ketamine Infusion on Surgical Recovery Completed · 7 cited
  14. Phase 4 The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery Completed · 6 cited
  15. Phase 4 Prevention of Persistent Opioid Use in Mothers Completed · 5 cited
  16. Phase 4 Ketamine for Acute Pain Management After Trauma Completed · 5 cited
  17. Phase 4 Dronabinol in Total Knee Arthroplasty (TKA) Completed
  18. Phase 4 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section Completed
  19. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  20. Phase 4 Gabapentin Regimens and Their Effects on Opioid Consumption Completed
  21. Phase 4 IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty Completed
  22. Phase 4 Improving Post-Operative Pain and Recovery in Gynecologic Surgery Completed
  23. Phase 4 Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty Completed
  24. Phase 4 Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery Completed
  25. Phase 4 Rapid Initiation of Drug Treatment Engagement Completed
  26. Phase 4 Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection Completed
  27. Phase 4 Buprenorphine Loading in the Emergency Department Completed
  28. Phase 4 Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery Completed
  29. Phase 4 The Impact of Sublingual Sufentanil on Postoperative Pain and Analgesic Requirements in Spine Surgery Patients Completed
  30. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  31. Phase 4 Cannabidiol for Bilateral Total Knee Arthroplasty Completed
  32. Phase 3 Lorcaserin in Combination With XR-Naltrexone for Relapse Prevention in Opioid Use Disorder Completed
  33. Phase 3 Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery Completed
  34. Phase 3 Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial Completed
  35. Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Completed
  36. Phase 3 Exparel Use in Adductor Canal Block After Total Knee Arthroplasty Completed
  37. Phase 3 A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders Completed
  38. Phase 3 Lidocaine Patches After Cesarean Section Completed
  39. Phase 3 Perioperative Pregabalin in Ureteroscopy Completed
  40. Phase 2 Impact of Lofexidine on Stress, Craving and Opioid Use Completed
  41. Phase 2 Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections Completed
  42. Phase 2 A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists. Completed
  43. Phase 2 Enhancing Medication-based Analgesia in Humans- STUDY 2 Completed
  44. Phase 2 Remote Observed Dosing of Suboxone to Improve Clinical Practice Completed

Showing the 50 most-cited and recently-updated of 202 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Opioid Use Disorder: what the trials found

New evidence indicates that cannabidiol was evaluated for its impact on cumulative opioid usage in the first 72 hours postoperatively 1. Additionally, Dronabinol 5mg Cap demonstrated no statistically significant differences in cumulative opioid consumption over 24-48 hours post-operatively 2, nor did it significantly impact time to discharge from physical therapy or average pain scores during ambulation 2.

Extended-Release Naltrexone was shown to result in specific scores for alcohol use and subacute withdrawal symptoms 21. Furthermore, OxyCODONE 5 Mg Oral Tablet was evaluated regarding Brief Pain Inventory (BPI) scores 22.

Recent results — preliminary, needs further review

  • • Buprenorphine combined with outpatient parenteral antibiotic therapy 3.
  • • Suvorexant (dual orexin receptor antagonist) 4.
  • • BIOPIN-6 Active Implant with Naltrexone 5.
  • • Marijuana, which showed varying results in self-administration of drug units 6.
  • • Steps 2 Change (S2C) 7.

For the clinician treating this condition

  • Dronabinol 5mg may be utilized postoperatively as it did not significantly increase opioid consumption or impact pain scores during ambulation compared to controls 2.
  • Ketamine administration is associated with a statistically significant difference in the occurrence of neuropsychiatric adverse events 15.
  • Self-Driven Repetitive Artmaking has been shown to significantly reduce patient anxiety, depression, and reported pain levels 14.

AI synthesis of 11 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy
Anesthesiology & Pain Medicine RCT
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy Small study tests brain stimulation and AI for opioid addiction in men
A small RCT in 36 male methadone maintenance patients and 24 healthy controls found that active tDCS groups showed significant craving reduc…
A machine learning algorithm identified opioid addiction with 94.3% accuracy in a small study, and brain stimulation reduced cravings in men…
Apr 2, 2026
Scoping review maps 31 U.S. interventions for opioid use disorder during pregnancy by socioecological level
Psychiatry Meta-analysis
Scoping review maps 31 U.S. interventions for opioid use disorder during pregnancy by socioecological level What helps pregnant women with opioid addiction? A new review maps the options
A scoping review of 31 U.S. intervention studies for pregnant individuals with opioid use disorder found 55% focused on individual-level app…
A review of U.S. research found 31 interventions for pregnant women with opioid addiction, with over half focusing on individual care like m…
Frontiers Apr 2, 2026
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use
Psychiatry Phase IV
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use Could Ketamine Be the Key to Easing Pain and Healing Minds After Surgery?
This Phase 4 trial investigates ketamine's efficacy in reducing postoperative pain and opioid use in orthopedic trauma patients.
A new trial tests if giving ketamine during orthopedic surgery reduces pain, opioid needs, and symptoms of depression and PTSD compared to s…
CT.gov Mar 27, 2026

Questions about Opioid Use Disorder

Are there differences in newborn growth measurements for babies exposed to opioids in the womb?

Yes, babies exposed to opioids in the womb tend to have lower birth weight and smaller head circumference, with differences depending on the specific medication used.

Full answer →