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Home › Conditions › Opioid Use Disorder

Opioid Use Disorder

Subtypes of Opioid Use Disorder

Opioid Overdose 8 Opioid dependence 2 Opioid Addiction 1 Prescription Opioid Misuse 0

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Opioid Use Disorder

202 trials tracked for Opioid Use Disorder: 45 in phase 3 or 4 and 23 with published results. The most-cited published study has 167 citations.

202Trials tracked
45Phase 3 & 4
0Recruiting
23With published results
Phase distribution
Phase 4 26 Phase 3 19 Phase 2 19 Phase 1 18 Other / NA 120
  1. Phase 3 Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain Completed · 167 cited
  2. Phase 3 Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder Completed · 112 cited
  3. Phase 3 Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study Completed · 59 cited
  4. Phase 3 Does a Non-Opioid Multimodal Pain (NOMO) Protocol Decrease Narcotic Use Completed · 50 cited
  5. Phase 3 Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension) Completed · 48 cited
  6. Phase 4 Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment Completed · 47 cited
Show 44 more trials
  1. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 27 cited
  2. Phase 4 Pain Control Following Sinus Surgery Completed · 20 cited
  3. Phase 4 SUBLOCADE Rapid Initiation Study Completed · 16 cited
  4. Phase 3 Safety and Tolerability Study of Depot Buprenorphine in Treatment Seeking Subjects With Opioid Use Disorder Completed · 13 cited
  5. Phase 3 Open-Label Treatment Extension Study Completed · 13 cited
  6. Phase 3 Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up Completed · 13 cited
  7. Phase 4 Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control Completed · 11 cited
  8. Phase 3 Opioid Prescription After Cesarean Trial Completed · 11 cited
  9. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  10. Phase 3 Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL Completed · 8 cited
  11. Phase 4 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery Completed · 6 cited
  12. Phase 4 Evaluation of Buprenorphine Extended-Release Subcutaneous Injection at Alternative Injection Locations Completed · 6 cited
  13. Phase 4 The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery Completed · 6 cited
  14. Phase 4 The Impact of Perioperative Ketamine Infusion on Surgical Recovery Completed · 6 cited
  15. Phase 4 Prevention of Persistent Opioid Use in Mothers Completed · 5 cited
  16. Phase 4 Ketamine for Acute Pain Management After Trauma Completed · 5 cited
  17. Phase 4 Dronabinol in Total Knee Arthroplasty (TKA) Completed
  18. Phase 4 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section Completed
  19. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  20. Phase 4 Gabapentin Regimens and Their Effects on Opioid Consumption Completed
  21. Phase 4 IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty Completed
  22. Phase 4 Improving Post-Operative Pain and Recovery in Gynecologic Surgery Completed
  23. Phase 4 Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty Completed
  24. Phase 4 Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery Completed
  25. Phase 4 Rapid Initiation of Drug Treatment Engagement Completed
  26. Phase 4 Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection Completed
  27. Phase 4 Buprenorphine Loading in the Emergency Department Completed
  28. Phase 4 Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery Completed
  29. Phase 4 The Impact of Sublingual Sufentanil on Postoperative Pain and Analgesic Requirements in Spine Surgery Patients Completed
  30. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  31. Phase 4 Cannabidiol for Bilateral Total Knee Arthroplasty Completed
  32. Phase 3 Lorcaserin in Combination With XR-Naltrexone for Relapse Prevention in Opioid Use Disorder Completed
  33. Phase 3 Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery Completed
  34. Phase 3 Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial Completed
  35. Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Completed
  36. Phase 3 Exparel Use in Adductor Canal Block After Total Knee Arthroplasty Completed
  37. Phase 3 A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders Completed
  38. Phase 3 Lidocaine Patches After Cesarean Section Completed
  39. Phase 3 Perioperative Pregabalin in Ureteroscopy Completed
  40. Phase 2 Impact of Lofexidine on Stress, Craving and Opioid Use Completed
  41. Phase 2 Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections Completed
  42. Phase 2 A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists. Completed
  43. Phase 2 Enhancing Medication-based Analgesia in Humans- STUDY 2 Completed
  44. Phase 2 Remote Observed Dosing of Suboxone to Improve Clinical Practice Completed

Showing the 50 most-cited and recently-updated of 202 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries
Infectious Disease
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries Analysis looks at overdose deaths involving both opioids and stimulants across different jobs
An observational report analyzed synthetic opioid and stimulant co-involved overdose deaths across occupations and industries in the United …
A new analysis examines how different jobs and industries might connect to overdose deaths involving both synthetic opioids and stimulants.
CDC Apr 5, 2026
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses
Infectious Disease
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses What prescriptions did people have before dying from an overdose in Pennsylvania?
An observational report from Pennsylvania analyzed controlled substance prescribing patterns preceding fatal overdoses involving opioids, st…
A new Pennsylvania report maps the controlled substance prescriptions people received before dying from an overdose involving opioids or sti…
CDC Apr 5, 2026
Nitazene-related deaths reported in Tennessee field notes
Infectious Disease
Nitazene-related deaths reported in Tennessee field notes Health officials report nitazene-related overdose deaths in Tennessee
Field notes from Tennessee report nitazene-related deaths. The study type, population, and specific results were not reported. Clinicians sh…
Tennessee health officials warn that nitazenes, powerful synthetic opioids sometimes mixed with other drugs, are linked to recent overdose d…
CDC Apr 5, 2026
Protocol outlines target trial emulation for bipolar disorder treatments in patients with opioid use disorder
Psychiatry RCT
Protocol outlines target trial emulation for bipolar disorder treatments in patients with opioid use disorder Study protocol compares bipolar disorder medications for people with opioid use disorder
This protocol describes a planned target trial emulation study using population-level administrative data from British Columbia and Ontario,…
People with bipolar disorder and opioid use disorder face higher risks, but a new plan will compare how well different medications work for …
medRxiv Apr 4, 2026
Case series identifies 38 medetomidine-involved opioid overdoses in Chicago
Infectious Disease
Case series identifies 38 medetomidine-involved opioid overdoses in Chicago Chicago health officials identify overdoses involving veterinary sedative mixed with opioids
A case series in Chicago identified 38 individuals with medetomidine-involved opioid overdoses (12 confirmed, 26 probable).
Chicago officials warn that a veterinary sedative is now mixed with opioids in street drugs, causing 38 overdoses in the city.
CDC Apr 4, 2026
Case series describes possible severe withdrawal syndrome in 23 patients using illegal opioids in Pittsburgh
Infectious Disease
Case series describes possible severe withdrawal syndrome in 23 patients using illegal opioids in Pittsburgh Doctors report possible severe withdrawal in 23 patients using illegal opioids in Pittsburgh
A case series of 23 patients in Pittsburgh hospitals who used illegally manufactured opioids reported a possible severe withdrawal syndrome.
Doctors in Pittsburgh report 23 patients using illegal opioids experienced possible severe withdrawal, highlighting a potential risk that ne…
CDC Apr 4, 2026
Lifetime opioid overdose reported by 55% of pregnant individuals with OUD in buprenorphine treatment study
Anesthesiology & Pain Medicine RCT
Lifetime opioid overdose reported by 55% of pregnant individuals with OUD in buprenorphine treatment study What puts pregnant women with opioid addiction at highest risk for overdose?
A descriptive analysis of baseline data from a multisite RCT of 140 pregnant individuals with OUD receiving buprenorphine found 55% reported…
Pregnant women in opioid treatment face high overdose risk if they have used heroin, experienced trauma, or rely on others for money.
Apr 3, 2026
National trends show rising Hepatitis C and opioid use disorder rates in pregnant women at delivery
Gastroenterology
National trends show rising Hepatitis C and opioid use disorder rates in pregnant women at delivery Study finds rising Hepatitis C and opioid disorder rates among pregnant women in the U.S
An observational study of pregnant women at delivery hospitalization in the United States from 2000-2015 found significant increases in both…
Hepatitis C and opioid use disorder rates rose significantly among U.S. pregnant women delivering in hospitals between 2000 and 2015.
CDC Apr 3, 2026
Telemedicine-Assisted Buprenorphine Induction Non-Inferior to Standard Care for OUD Retention
Anesthesiology & Pain Medicine RCT
Telemedicine-Assisted Buprenorphine Induction Non-Inferior to Standard Care for OUD Retention Can starting addiction treatment by video work as well as in-person visits?
A randomized controlled non-inferiority trial in 138 adults with opioid use disorder in India found telemedicine-assisted buprenorphine indu…
Patients starting opioid addiction treatment via video calls stay in care just as well as those with in-person visits during the first week.
Apr 2, 2026
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy
Anesthesiology & Pain Medicine RCT
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy Small study tests brain stimulation and AI for opioid addiction in men
A small RCT in 36 male methadone maintenance patients and 24 healthy controls found that active tDCS groups showed significant craving reduc…
A machine learning algorithm identified opioid addiction with 94.3% accuracy in a small study, and brain stimulation reduced cravings in men…
Apr 2, 2026
Scoping review maps 31 U.S. interventions for opioid use disorder during pregnancy by socioecological level
Psychiatry Meta-analysis
Scoping review maps 31 U.S. interventions for opioid use disorder during pregnancy by socioecological level What helps pregnant women with opioid addiction? A new review maps the options
A scoping review of 31 U.S. intervention studies for pregnant individuals with opioid use disorder found 55% focused on individual-level app…
A review of U.S. research found 31 interventions for pregnant women with opioid addiction, with over half focusing on individual care like m…
Frontiers Apr 2, 2026
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use
Psychiatry Phase IV
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use Could Ketamine Be the Key to Easing Pain and Healing Minds After Surgery?
This Phase 4 trial investigates ketamine's efficacy in reducing postoperative pain and opioid use in orthopedic trauma patients.
A new trial tests if giving ketamine during orthopedic surgery reduces pain, opioid needs, and symptoms of depression and PTSD compared to s…
CT.gov Mar 27, 2026

Questions about Opioid Use Disorder

Are there differences in newborn growth measurements for babies exposed to opioids in the womb?

Yes, babies exposed to opioids in the womb tend to have lower birth weight and smaller head circumference, with differences depending on the specific medication used.

Full answer →