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Opioid Use Disorder

Subtypes of Opioid Use Disorder

Opioid Overdose 8 Opioid dependence 2 Opioid Addiction 1 Prescription Opioid Misuse 0

33 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Opioid Use Disorder

202 trials tracked for Opioid Use Disorder: 45 in phase 3 or 4 and 23 with published results. The most-cited published study has 170 citations.

202Trials tracked

45Phase 3 & 4

0Recruiting

23With published results

Phase distribution

Phase 4 26 Phase 3 19 Phase 2 19 Phase 1 18 Other / NA 120

Phase 3 Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain Completed · 170 cited
Phase 3 Long-Term Safety Study of Buprenorphine (CAM2038) in Adult Outpatients With Opioid Use Disorder Completed · 115 cited
Phase 3 Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study Completed · 61 cited
Phase 3 Does a Non-Opioid Multimodal Pain (NOMO) Protocol Decrease Narcotic Use Completed · 51 cited
Phase 4 Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment Completed · 50 cited
Phase 3 Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension) Completed · 50 cited

Show 44 more trials

Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 30 cited
Phase 4 Pain Control Following Sinus Surgery Completed · 20 cited
Phase 4 SUBLOCADE Rapid Initiation Study Completed · 16 cited
Phase 4 Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control Completed · 14 cited
Phase 3 Open-Label Treatment Extension Study Completed · 14 cited
Phase 3 Safety and Tolerability Study of Depot Buprenorphine in Treatment Seeking Subjects With Opioid Use Disorder Completed · 14 cited
Phase 4 The Impact of Perioperative Ketamine Infusion on Surgical Recovery Completed · 12 cited
Phase 3 Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up Completed · 12 cited
Phase 3 Opioid Prescription After Cesarean Trial Completed · 11 cited
Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
Phase 4 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery Completed · 8 cited
Phase 4 Evaluation of Buprenorphine Extended-Release Subcutaneous Injection at Alternative Injection Locations Completed · 8 cited
Phase 4 Ketamine for Acute Pain Management After Trauma Completed · 8 cited
Phase 3 Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL Completed · 8 cited
Phase 4 Prevention of Persistent Opioid Use in Mothers Completed · 6 cited
Phase 4 The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery Completed · 6 cited
Phase 4 Dronabinol in Total Knee Arthroplasty (TKA) Completed
Phase 4 Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section Completed
Phase 4 Opioid-Free Shoulder Arthroplasty Completed
Phase 4 Gabapentin Regimens and Their Effects on Opioid Consumption Completed
Phase 4 IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty Completed
Phase 4 Improving Post-Operative Pain and Recovery in Gynecologic Surgery Completed
Phase 4 Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty Completed
Phase 4 Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery Completed
Phase 4 Rapid Initiation of Drug Treatment Engagement Completed
Phase 4 Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection Completed
Phase 4 Buprenorphine Loading in the Emergency Department Completed
Phase 4 Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery Completed
Phase 4 The Impact of Sublingual Sufentanil on Postoperative Pain and Analgesic Requirements in Spine Surgery Patients Completed
Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
Phase 4 Cannabidiol for Bilateral Total Knee Arthroplasty Completed
Phase 3 Lorcaserin in Combination With XR-Naltrexone for Relapse Prevention in Opioid Use Disorder Completed
Phase 3 Patient-Directed Postoperative Opioid Prescribing for Gynecologic Surgery Completed
Phase 3 Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial Completed
Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Completed
Phase 3 Exparel Use in Adductor Canal Block After Total Knee Arthroplasty Completed
Phase 3 A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders Completed
Phase 3 Lidocaine Patches After Cesarean Section Completed
Phase 3 Perioperative Pregabalin in Ureteroscopy Completed
Phase 2 Impact of Lofexidine on Stress, Craving and Opioid Use Completed
Phase 2 Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections Completed
Phase 2 A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists. Completed
Phase 2 Enhancing Medication-based Analgesia in Humans- STUDY 2 Completed
Phase 2 Remote Observed Dosing of Suboxone to Improve Clinical Practice Completed

Showing the 50 most-cited and recently-updated of 202 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Opioid Use Disorder: what the trials found

New evidence indicates that cannabidiol was evaluated for its impact on cumulative opioid usage in the first 72 hours postoperatively ¹. Additionally, Dronabinol 5mg Cap demonstrated no statistically significant differences in cumulative opioid consumption over 24-48 hours post-operatively ², nor did it significantly impact time to discharge from physical therapy or average pain scores during ambulation ².

Extended-Release Naltrexone was shown to result in specific scores for alcohol use and subacute withdrawal symptoms ²¹. Furthermore, OxyCODONE 5 Mg Oral Tablet was evaluated regarding Brief Pain Inventory (BPI) scores ²².

Recent results — preliminary, needs further review

• Buprenorphine combined with outpatient parenteral antibiotic therapy ³.
• Suvorexant (dual orexin receptor antagonist) ⁴.
• BIOPIN-6 Active Implant with Naltrexone ⁵.
• Marijuana, which showed varying results in self-administration of drug units ⁶.
• Steps 2 Change (S2C) ⁷.

For the clinician treating this condition

Dronabinol 5mg may be utilized postoperatively as it did not significantly increase opioid consumption or impact pain scores during ambulation compared to controls ².
Ketamine administration is associated with a statistically significant difference in the occurrence of neuropsychiatric adverse events ¹⁵.
Self-Driven Repetitive Artmaking has been shown to significantly reduce patient anxiety, depression, and reported pain levels ¹⁴.

AI synthesis of 11 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

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Questions about Opioid Use Disorder

Are there differences in newborn growth measurements for babies exposed to opioids in the womb?

Yes, babies exposed to opioids in the womb tend to have lower birth weight and smaller head circumference, with differences depending on the specific medication used.

Full answer →