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Home › Conditions › Psychosis

Psychosis

Subtypes of Psychosis

First-Episode Psychosis 8 Psychotic disorders 8 Clinical High-Risk for Psychosis 2 Schizoaffective disorder 2 Medically-associated psychosis 1 Substance-/medication-induced psychosis 1

25 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Psychosis

34 trials tracked for Psychosis: 4 in phase 3 or 4.

34Trials tracked
4Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 4 Phase 1 2 Other / NA 24
  1. Phase 4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Completed
  2. Phase 3 Open-label Ziprasidone Study for Psychosis Treatment in Adolescents Completed
  3. Phase 3 Aspirin in Young Psychotic Patients Completed
  4. Phase 3 Study of Asenapine in Elderly Subjects With Psychosis (A7501021)(P05717) Completed
  5. Phase 2 Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders Completed
  6. Phase 2 Levetiracetam in Early Psychosis Completed
Show 28 more trials
  1. Phase 2 Treatment of Psychosis and Agitation in Alzheimer's Disease Completed
  2. Phase 2 Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia Completed
  3. Phase 1 Developing Clinical Tools to Communicate Genetic Risk for Individuals Who Are Clinical High Risk for Psychosis Completed
  4. Phase 1 NAPLS Omega-3 Fatty Acid Versus Placebo Study Completed
  5. N/A Effect Evaluation of Individual Placement and Support (IPS) Completed
  6. N/A Mindfulness, Group Therapy and Psychosis; Training Decreases Anxiety and Depression Completed
  7. N/A Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia Completed
  8. N/A Vitamin D Supplementation in Psychiatric Illnesses Completed
  9. N/A Treatment to Enhance Cognition in Bipolar Disorder Completed
  10. N/A Social Cognition Intervention Completed
  11. N/A Feasibility of an Early Detection Program for Early Psychosis on a College Campus Completed
  12. N/A Effectiveness of Cognitive Remediation in a Supported Education Setting Completed
  13. N/A Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study Completed
  14. N/A Testing the Effectiveness of The Welcome Basket Intervention Completed
  15. N/A CBT-I for Psychosis: Guidelines, Preliminary Efficacy, and Functional Outcomes Completed
  16. N/A Minnesota Community-Based Cognitive Training in Early Psychosis Completed
  17. N/A USS Training to Improve Social Function in People With Psychosis Completed
  18. N/A The Family Cognitive Adaptation Training Manual: A Test of Effectiveness Completed
  19. N/A mHealth for Psychosis Help-seeking Completed
  20. N/A The Relationship Between Autobiographical Memory and Motivation Completed
  21. N/A Improving Hallucinations by Targeting the rSTS With tES Completed
  22. N/A CBTpro: Scaling up CBT for Psychosis Using Simulated Patients and Spoken Language Technologies Completed
  23. N/A Cognitive Behavioral Suicide Prevention for Psychosis: Aim 1 Completed
  24. N/A Families With Substance Use and Psychosis: A Pilot Study Completed
  25. N/A Pilot Study of Motivational Interviewing for Loved Ones Completed
  26. N/A Improving Adherence to Cognitive Rehabilitation Completed
  27. N/A Cognitive Behavioral Suicide Prevention for Psychosis: Aim 2 Completed
  28. N/A Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Psychosis Completed

Showing the 34 most-cited and recently-updated of 34 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Psychosis: what the trials found

Pharmacological management of psychosis includes the use of Ziprasidone 6 and Asenapine 7.

Lamotrigine was evaluated for its impact on alcohol use in patients with psychosis; results showed a mean of 78.7% to 80.1% days abstinent from alcohol, with MADRS scores ranging from 6.93 to 12.05 4.

Aspirin was studied for its effect on psychopathology (PANSS) and cognitive measures (MoCA), but did not show statistically significant differences in these outcomes (p=0.133 and p=1.607, respectively) 5.

Recent results — preliminary, needs further review

  • CBTpro was associated with specific mean scores on the Revised Green Paranoid Thoughts Scale (R-GPTS) and Sheehan Disability Scale (SDS) 2.
  • CRAFT-EP significantly improved family wellbeing by reducing depression (p=0.026) and anxiety (p=0.003), though it did not reach statistical significance for improving relationship scores (p=0.091) 3.
  • Guided Autobiographical Memory Recall was associated with post-intervention motivation scores of 81.01 and 72.89 16.
  • Other recent interventions include Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) 1, Transcranial Electrical Stimulation 14, and the NORTH "Full" protocol 15.

For the clinician treating this condition

  • Ziprasidone and Asenapine are established pharmacological options for psychosis management.
  • Lamotrigine has been shown to correlate with specific alcohol abstinence rates in this population.
  • CRAFT-EP is an effective intervention for improving family members' anxiety and depression levels.

AI synthesis of 10 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use
Psychiatry Phase III
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use Hong Kong trial planned to test antipsychotic injections for substance use with psychosis
A trial record describes a planned phase 2/3 study of 165 individuals in Hong Kong with substance use disorders and psychosis.
Hong Kong researchers plan a trial to test long-acting antipsychotic injections for people with substance use disorders and psychosis.
CT.gov Apr 3, 2026

Questions about Psychosis

Can psychological therapy help with depression and early psychosis?

Yes, psychological therapy can help with depression and early psychosis, reducing hospitalizations and improving outcomes.

Full answer →
What is the overall chance of having psychosis if I have lupus?

Based on a large meta-analysis, about 4.5% of adults with lupus experience psychosis, with higher risk in those with active disease or certain antibodies.

Full answer →