Observational cohort links symptom severity subgroups to poorer functioning and brain volume in psychosis and depression risk
Severe Mental Symptoms Share Hidden Common Cause
This observational cohort study stratified 749 participants into transdiagnostic symptom severity subgroups.
This could explain why different mental illnesses feel so similar in early stages.
Observational study evaluates dynamic prediction model for clozapine initiation in Danish schizophrenia patients
Can we predict who needs clozapine soon? A new model says yes for many patients
This observational research article evaluates a dynamic prediction model designed to forecast incident clozapine prescriptions within 365 da…
A new model predicts which schizophrenia patients need clozapine within a year, helping doctors start this life-saving treatment sooner for …
Cognitive Remediation Therapy Re-analysis Shows Benefit Over Treatment As Usual on Global Assessment Scale
When Patients Rank Treatment Success Differently Than Doctors
This re-analysis of a randomized controlled trial evaluated Cognitive Remediation Therapy versus treatment as usual among participants and s…
Patients and doctors value different treatment benefits, and letting patients help decide what counts as success can change how we understan…
In children with first psychotic symptoms, 23.5% had substance- or medically-associated psychosis after extensive workup
Medical testing found substance or medical causes in 23.5% of youth with new psychosis
This retrospective cohort study evaluated 68 children and adolescents admitted for a first presentation of psychotic symptoms at a tertiary …
Medical testing found substance or medical causes in 23.5% of youth with new psychosis, proving a thorough workup is essential before diagno…
Criminal legal involvement correlates with baseline symptoms and substance use in US first-episode psychosis patients
Early psychosis care may lower the risk of arrest
This secondary analysis of a cluster randomized controlled trial examined criminal legal involvement (CLI) in 381 US patients with first-epi…
When psychosis is caught and treated sooner, people are less likely to end up tangled in the legal system during recovery.
Systematic review finds immune markers IL-1β and TNF-α associated with negative symptoms in first episode psychosis
Inflammation Linked to Low Energy in Early Psychosis
A systematic review of 7 case-control studies found individuals with first episode psychosis generally showed elevated peripheral blood immu…
High levels of inflammatory markers in the blood are linked to the low energy and lack of motivation seen in people with early psychosis.
Extended early intervention service improves functioning in first-episode psychosis versus standard care
Extending early intervention services may improve functioning for some young people with first-episode psychosis
A randomized controlled trial of 400 individuals with first-episode psychosis found that extending early intervention service (EIS) for one …
Extending early intervention care for young people with first-episode psychosis leads to higher employment rates and better social functioni…
Meta-analysis finds sleep architecture differences in drug-free schizoaffective disorder patients
Drug-free schizoaffective patients show distinct sleep pattern differences compared to healthy controls and other groups
A meta-analysis of case-control studies compared polysomnographic sleep parameters in 67 drug-free schizoaffective patients against healthy …
People with schizoaffective disorder who aren't on medication sleep less, stay awake longer, and struggle to reach deep rest compared to hea…
Large language models show potential for psychosis risk assessment from clinical interview transcripts
AI language models show promise for assessing early psychosis risk from interviews
An evaluation study of 373 participants with clinical high risk for psychosis transcripts found that large language models (LLMs) achieved 8…
Large AI models correctly identified early psychosis risk 80% of the time from interview transcripts, matching human expert scores while mos…
Corticolimbic Glutamate-Functional Connectivity Associations Found in Antipsychotic-Naive CHR-P Individuals
Could early brain changes in psychosis risk be linked to specific chemical connections?
An observational study of antipsychotic-naive clinical high-risk for psychosis (CHR-P) participants (n=22), healthy controls (n=23), and fir…
People at high risk for psychosis show weaker brain chemical connections before symptoms appear, unlike those who have already developed the…
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight.
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
12-year follow-up of extended early intervention for first-episode psychosis in Hong Kong
Long-term study tracks recovery rates for people with first psychosis episode
A 12-year follow-up of an RCT in Hong Kong compared a 1-year extension of early intervention (3-year EI) to 1-year step-down care (2-year EI…
Twelve years after a first psychosis episode, only 25% of patients regained daily functioning, though extra early care helped control sympto…
Questions about Psychosis
Can psychological therapy help with depression and early psychosis?
Yes, psychological therapy can help with depression and early psychosis, reducing hospitalizations and improving outcomes.
Full answer →What is the overall chance of having psychosis if I have lupus?
Based on a large meta-analysis, about 4.5% of adults with lupus experience psychosis, with higher risk in those with active disease or certain antibodies.
Full answer →