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Home › Conditions › Sarcopenia

Sarcopenia

28 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sarcopenia

47 trials tracked for Sarcopenia: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 73 citations.

47Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 11 Phase 1 3 Other / NA 29
  1. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 73 cited
  2. Phase 3 Effect Of Ophiochepalus Striatus Extract On Serum IGF-1 And IL-6 Levels In Elderly Patients With Sarcopenia Completed · 3 cited
  3. Phase 4 Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men Completed
  4. Phase 3 Carnitine Supplementation and Skeletal Muscle Function Completed
  5. Phase 2 The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Completed
  6. Phase 2 Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial. Completed
Show 41 more trials
  1. Phase 2 Biological Effects of Weight Loss In Older, Obese Women Completed
  2. Phase 2 Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease Completed
  3. Phase 2 A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study Completed
  4. Phase 2 Dose Range Finding Study of Bimagrumab in Sarcopenia Completed
  5. Phase 2 A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005) Completed
  6. Phase 2 A Study of Muscle Strength Maintenance in Older Adults Completed
  7. Phase 2 A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT) Completed
  8. Phase 2 Trial of Oral Glutamine on Mitochondrial Function in CKD Completed
  9. Phase 2 5-Alpha Reductase and Anabolic Effects of Testosterone Completed
  10. Phase 1 Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Completed
  11. Phase 1 Effect of a Ghrelin Receptor Agonist on Muscle and Bone Completed
  12. Phase 1 Ankle Assistance and Resistance in Older Adults Completed
  13. N/A The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia Completed
  14. N/A Effect of an EAA/Whey Composition on Protein Metabolism Completed
  15. N/A Omega-3 Supplementation and Resistance Training Completed
  16. N/A The Efficacy of Aerobic Exercise Training on ANS and Endothelial Function in Compensated Cirrhosis Completed
  17. N/A Prognostic Value of Sarcopenia and Nutritional Status in Early-stage Non-small Cell Lung Cancer Completed
  18. N/A Study of the Long-term Effects of Exercise on Heath Indicators in Older People Completed
  19. N/A Blood Flow, Muscle Regeneration and Sarcopenia Completed
  20. N/A Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly Completed
  21. N/A Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults Completed
  22. N/A Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health Completed
  23. N/A Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults Completed
  24. N/A A Physical Activity Program in End-state Liver Disease Completed
  25. N/A Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults Completed
  26. N/A The Urinary Incontinence Treatment Study Completed
  27. N/A VR-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents Completed
  28. N/A Time Course Adaptations Using Deuterated Creatine (D3Cr) Method Completed
  29. N/A Semi-Recumbent Vibration Therapy in Older Adults Completed
  30. N/A Integrated Physical Training With Protein Diet in Older Adults With Sarcopenia Symptoms. Completed
  31. N/A Identifying Therapeutic Targets of Accelerated Sarcopenia Completed
  32. N/A IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial Completed
  33. N/A Nutritional Biomarkers of Sarcopenia Completed
  34. N/A Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training Completed
  35. N/A Dietary Nitrate and Muscle Power With Aging Completed
  36. N/A Muscle Capillarization and Sarcopenia Completed
  37. N/A The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. Completed
  38. N/A Effects of a Resistance Training Program in Older Women With Sarcopenia Completed
  39. N/A Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics Completed
  40. N/A FrAilty Care and wEll-funcTion in Community Dwelling Older Adults Completed
  41. N/A Bingocize: A Novel Mobile Application for Older Adult Health Completed

Showing the 47 most-cited and recently-updated of 47 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ultrasound predicts lower limb muscle fat; 12-week resistance exercise raised strength without changing fat fraction
Radiology & Imaging RCT
Ultrasound predicts lower limb muscle fat; 12-week resistance exercise raised strength without changing fat fraction Can simple exercise build muscle strength and lower body fat in healthy adults?
This randomised controlled trial developed and validated an ultrasound-based prediction equation for lower limb muscle fat fraction and test…
Low impact resistance exercise builds muscle strength in healthy women over three months, but does not lower muscle fat during the same peri…
Apr 15, 2026
Group dance interventions improved physical performance and cognition in community-dwelling older adults with sarcopenia
Geriatrics & Aging Meta-analysis
Group dance interventions improved physical performance and cognition in community-dwelling older adults with sarcopenia Why Group Dance Is Becoming Medicine for Aging Muscles
This mixed methods systematic review and meta-analysis evaluated group dance interventions in community-dwelling older adults with sarcopeni…
Group dance helps older adults move better, think sharper, and stay socially connected, though it does not build muscle like strength traini…
Apr 14, 2026
Phenolic-rich olive oil with prebiotics may improve muscle measures in older adults with sarcopenia
Geriatrics & Aging RCT
Phenolic-rich olive oil with prebiotics may improve muscle measures in older adults with sarcopenia Olive Oil and Prebiotics Team Up to Fight Muscle Loss in Older Adults
A small randomized controlled trial in 38 home-dwelling older adults with probable sarcopenia found that phenolic-rich extra virgin olive oi…
A specific extra virgin olive oil paired with prebiotic fiber helped rebuild shrinking muscles in older adults with early signs of muscle lo…
Apr 14, 2026
Sarcopenia linked to higher acute cholecystitis risk in older adults with incidental gallstones
Rheumatology Cohort
Sarcopenia linked to higher acute cholecystitis risk in older adults with incidental gallstones Muscle Loss May Predict a Painful Gallbladder Attack in Older Adults
A retrospective cohort study of 1,177 patients aged ≥65 years with incidental gallstones found sarcopenia was associated with a 3.6-fold inc…
Older adults with low muscle mass are 3.5 times more likely to develop a sudden, severe gallbladder infection than those with obesity.
Frontiers Apr 14, 2026
Cross-sectional study links CKD, sarcopenia, and undernutrition to CVD history in older Japanese adults
Geriatrics & Aging
Cross-sectional study links CKD, sarcopenia, and undernutrition to CVD history in older Japanese adults Two Quiet Conditions Quintuple Heart Disease Risk After 65
A cross-sectional study of 307 community-dwelling Japanese adults aged ≥65 years found CKD, sarcopenia, undernutrition, and low physical act…
Checking kidneys and muscle strength together may catch older adults whose heart risk is hiding in plain sight.
medRxiv Apr 13, 2026
HIIT reduces sarcopenia risk and preserves grip strength in older adults over 5-year RCT
Geriatrics & Aging RCT
HIIT reduces sarcopenia risk and preserves grip strength in older adults over 5-year RCT Can short bursts of intense exercise help older adults stay stronger longer?
A 5-year RCT in 1,567 Norwegian adults aged 70-75 found high-intensity interval training (HIIT) reduced odds of clinically defined sarcopeni…
Short bursts of intense exercise helped older adults lose less grip strength and walk faster for five years, cutting sarcopenia risk in half…
Apr 8, 2026
Resistance and interval training plus berry extract did not alter muscle AGEs in older adults
Physical Medicine & Rehab RCT
Resistance and interval training plus berry extract did not alter muscle AGEs in older adults Exercise and berries did not change AGE levels in muscle tissue of older adults
A 12-week RCT in 41 healthy adults aged 55-70 found that supervised resistance and high-intensity interval training, preceded by 30 days of…
Exercise and berry supplements did not lower advanced glycation end-products in the muscle tissue of healthy older adults in this study.
Apr 8, 2026
Creatine supplementation increases anaerobic power in healthy men regardless of resistance training status
Nutrition & Obesity Medicine Meta-analysis
Creatine supplementation increases anaerobic power in healthy men regardless of resistance training status Creatine plus resistance training builds lean mass in young men
This systematic review and meta-analysis evaluated creatine supplementation in 39 trials involving healthy men aged 18–30 years.
Healthy young men who combined creatine with resistance training gained significantly more lean muscle mass and strength than those taking c…
Frontiers Apr 8, 2026
24-week self-determined sequence exercise program shows significant interactions for sarcopenia reversal in older adults
Geriatrics & Aging RCT
24-week self-determined sequence exercise program shows significant interactions for sarcopenia reversal in older adults New study tests exercise mix for muscle loss in older adults
This randomized controlled trial enrolled 91 older patients with sarcopenia aged 60 to 75 years.
A flexible exercise mix including Taichi and resistance training helped older adults with muscle loss regain strength and muscle area in a n…
Apr 6, 2026
Pilot trial finds no between-group muscle mass benefit from HMB supplement in cirrhosis sarcopenia
Gastroenterology RCT
Pilot trial finds no between-group muscle mass benefit from HMB supplement in cirrhosis sarcopenia Small pilot study tests nutritional supplement for muscle loss in liver cirrhosis
A pilot randomized controlled trial of 21 patients with stable decompensated cirrhosis and sarcopenia found no significant between-group dif…
A nutritional supplement with HMB improved leg strength and body composition in cirrhosis patients, though it did not increase overall muscl…
Apr 5, 2026
Whole-body vibration with blood flow restriction training may improve sarcopenia measures in older adults
Geriatrics & Aging RCT
Whole-body vibration with blood flow restriction training may improve sarcopenia measures in older adults Can a six-week vibration and blood flow workout help older adults regain muscle?
A 6-week randomized trial in 74 older patients with sarcopenia found that adding whole-body vibration training with blood flow restriction t…
A six-week mix of vibration and blood flow training helped older adults with muscle loss gain more strength and walk farther than nutrition …
Apr 4, 2026
Exercise training improves physical performance and handgrip strength in frail nursing home residents
Geriatrics & Aging
Exercise training improves physical performance and handgrip strength in frail nursing home residents Can exercise help nursing home residents stay stronger and more independent?
A 12-month pragmatic controlled trial in 95 frail nursing home residents found that twice-weekly resistance and aerobic exercise significant…
For older adults in nursing homes, staying physically strong is key to maintaining independence.
Apr 4, 2026

Questions about Sarcopenia

Can standard physical exam indicators accurately predict my sarcopenia risk?

Yes, standard physical exam indicators like calf circumference, BMI, and handgrip strength can predict sarcopenia risk with good accuracy, especially when combined in a validated model.

Full answer →
Does exercise lower TNF-alpha levels in older adults with sarcopenia?

Yes, exercise can lower TNF-alpha levels in older adults with sarcopenia, based on multiple clinical trials and meta-analyses.

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Do specific plasma metabolites change in older patients with sepsis and sarcopenia?

Yes, older patients with sepsis and sarcopenia show distinct plasma metabolomic changes, including altered amino acid, lipid, and steroid pathways, compared to those without sarcopenia.

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Does obstructive sleep apnea increase my risk of developing sarcopenia?

Yes, research suggests obstructive sleep apnea (OSA) is linked to a higher risk of sarcopenia, with meta-analyses showing about 85% increased odds, though the exact mechanisms are still being studied.

Full answer →