Sterile-site yeast isolates linked to fungemia, sepsis, and mortality in a retrospective cohort study.
Blood Infections From Yeast Are Changing—Here’s What Patients Need to Know
This retrospective cohort study analyzed 231 consecutive sterile-site yeast isolates from Nanjing Drum Tower Hospital between 2019 and 2023.…
This study shows that not all yeast infections are the same, and your specific risk factors—like kidney injury or recent surgery—can dramati…
Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline
Saline vs. Balanced Fluids: What ICU Patients Really Need
This systematic review and meta-analysis of 34 studies involving 37,859 participants evaluated buffered solutions versus 0.9% saline in crit…
A major review finds no survival benefit for balanced IV fluids over standard saline in ICU patients, though kidney effects remain unclear.
Prospective observational study of inflammatory mediators in adult ED patients with suspected infection.
Blood protein patterns in sick ER patients hint at who might survive
This primary prospective, observational study in a single-centre Emergency Department measured longitudinal inflammatory mediators in 173 ad…
In ER patients with suspected infection, certain blood proteins changed over time and linked to survival, offering clues for future monitori…
Meta-analysis finds preadmission metformin use associated with reduced mortality in diabetic sepsis patients
Metformin Linked to Lower Sepsis Death Risk
This systematic review and meta-analysis of 14 studies (12,687 patients) examined preadmission metformin use in diabetic sepsis patients. It…
Diabetic patients taking metformin before sepsis face nearly 40% lower death risk, suggesting this common pill may quietly boost survival du…
Systematic review proposes S100A8/A9–NETosis feedback loop as core sepsis mechanism.
Sepsis May Have a Hidden Engine Driving Death
This systematic review synthesizes evidence on sepsis, proposing the S100A8/A9–NETosis positive feedback loop as a core pathological mechani…
A dangerous cycle between immune cells and blood clots may be the hidden engine driving sepsis death, offering new ways to stop organ failur…
Hematocrit–albumin gap linked to sepsis risk in ICU adults in retrospective analysis
Does a simple blood number predict sepsis risk in ICU patients?
A retrospective cross-sectional analysis of 19,134 adults with first ICU admissions found that a higher hematocrit–albumin gap (HAG) was ass…
A simple blood number called the hematocrit–albumin gap predicts sepsis risk in ICU patients, with higher levels increasing infection odds b…
Narrative review on sepsis and the microbiome, highlighting unresolved causality and variability.
Could your sepsis treatment be missing a key clue about your unique biology?
This narrative review synthesizes current evidence on the microbiome in sepsis. The authors highlight unresolved causality, inter-individual…
Sepsis treatment risks vary by biology because gut bacteria and genes drive inflammation, yet doctors currently lack tools to predict who wi…
Insulin administration associated with lower 28-day mortality in non-diabetic sepsis patients.
Insulin Might Help Sepsis Patients Survive Longer
This retrospective cohort study of 11,289 non-diabetic patients with sepsis found insulin administration was associated with reduced 28-day …
Insulin therapy was linked to a 37% lower risk of death in non-diabetic sepsis patients, though it extended hospital stays.
Corticosteroids reduce short-term and long-term mortality in adult sepsis patients according to a systematic review.
What Doctors Give Sepsis Patients Is Finally Getting Clearer
This systematic review and network meta-analysis evaluated corticosteroids, specifically hydrocortisone and hydrocortisone plus fludrocortis…
Corticosteroids cut short-term and long-term sepsis death risk for ICU adults in large review, though doctors still need clearer guidance on…
Protein nutritional support in critically ill adults shows heterogeneous mortality benefits and potential harm from very high early doses.
Why ICU Patients Need More Protein, But Not Too Much
This narrative review evaluates protein supplementation strategies in critically ill adults, including those with sepsis or severe burns. Ev…
Doctors caring for patients in the ICU know protein matters for recovery, but a new review shows the right dose depends on the illness, the …
A 1-hour sepsis bundle is associated with reduced short-term mortality compared to non-bundle care in a meta-analysis of 4435 patients.
One Hour Saves Lives in Sepsis
This systematic review and meta-analysis evaluated the association between a 1-hour sepsis bundle and short-term mortality in 4435 patients …
A specific 1-hour checklist for treating sepsis significantly lowers short-term death rates compared to standard care, offering a simple way…
RDW trajectories during sepsis hospitalization predict 30- and 90-day mortality in retrospective study
Why a simple blood test predicts who gets sicker
A retrospective cohort study of 3,813 sepsis patients found that specific red blood cell distribution width (RDW) trajectories over the firs…
Tracking how your red blood cell size changes day by day reveals who is most likely to die from sepsis within 30 days.