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Substance Use Disorder

Part of Substance-Related Disorders

19 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Substance Use Disorder

117 trials tracked for Substance Use Disorder: 12 in phase 3 or 4 and 6 with published results. The most-cited published study has 312 citations.

117Trials tracked
12Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 6 Phase 3 6 Phase 2 13 Phase 1 5 Other / NA 87
  1. Phase 4 Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of Care Completed · 312 cited
  2. Phase 4 Feasibility and Acceptability of Digital Pills to Monitor PrEP Adherence in MSM With Substance Use Completed · 35 cited
  3. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 27 cited
  4. Phase 3 Homeless Care Management App Completed · 18 cited
  5. Phase 4 Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder Completed
  6. Phase 3 Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance Users (PrEPSteps) Completed
Show 44 more trials
  1. Phase 4 Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation Completed
  2. Phase 4 PrEP at a Syringe Services Program Completed
  3. Phase 4 Creatine as a Treatment Option for Depression in Methamphetamine Using Females Completed
  4. Phase 3 Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders Completed
  5. Phase 3 Adaptive Treatment for Alcohol and Cocaine Dependence Completed
  6. Phase 3 Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD) Completed
  7. Phase 2 Cognitive Stimulation Completed
  8. Phase 2 Guanfacine to Improve Substance Use Outcomes in Women Completed
  9. Phase 2 Pharmacogenetics of Naltrexone for Stimulant Abuse Completed
  10. Phase 2 Varenicline Treatment for Cannabis Use Disorder Completed
  11. Phase 2 The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use Completed
  12. Phase 2 Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment Completed
  13. Phase 2 Gabapentin for Bipolar & Cannabis Use Disorders Completed
  14. Phase 2 SMART Trial: Intrapersonal and Interpersonal Stigma Reduction Completed
  15. Phase 2 The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention Completed
  16. Phase 2 Brief Intervention in At-Risk First-time Mothers Completed
  17. Phase 2 Benzodiazepine Discontinuation in Opioid Agonist Therapy Completed
  18. Phase 2 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress Completed
  19. Phase 2 Mindfulness Based Relapse Prevention: Efficacy and Mechanisms Completed
  20. Phase 1 Multiple Ascending Dose Study of TMP-301 in Healthy Subjects Completed
  21. Phase 1 A Social Network AOD Intervention for Homeless Youth Transitioning to Housing Completed
  22. Phase 1 Woebot for Substance Use Disorders Completed
  23. Phase 1 W-SUDs for COVID-19 Completed
  24. Phase 1 A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants Completed
  25. N/A Southwest Hub for American Indian Youth Suicide Prevention Research Completed
  26. N/A Providing Expanded Continuous Labor Support to Pregnant Women in New Mexico With Substance Use Disorders Completed
  27. N/A The Substance Use and Health Risk Intervention (SUHRI) for Justice-involved Youth Completed
  28. N/A Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use Completed
  29. N/A Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care Completed
  30. N/A Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT Completed
  31. N/A Assessing the Effect of Distance Learning Vocational Rehabilitation on Employment Outcomes of Veterans With Psychiatric Illness and Histories of Legal Convictions Completed
  32. N/A Home Visitation Enhancing Linkages Project Completed
  33. N/A Using Aromatherapy in Substance Use Disorder Completed
  34. N/A Justice-Involved Veterans and Moral Reconation Therapy Completed
  35. N/A Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE) Completed
  36. N/A Collaborating to Implement Cross-System Interventions in Child Welfare and Substance Use Completed
  37. N/A Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs Completed
  38. N/A Integrated Care for Patients With High Risk Substance Use and Psychiatric Disorder With Chronic Direct Acting Antiviral Treatment Completed
  39. N/A Connect2BWell: An Evidence-Based Screening, Brief Intervention, and Referral to Treatment (SBIRT) Program Completed
  40. N/A Pilot of Pragmatic SBIRT Study Completed
  41. N/A Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study Completed
  42. N/A Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase Completed
  43. N/A Advancing Understanding of Transportation Options Completed
  44. N/A SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study) Completed

Showing the 50 most-cited and recently-updated of 117 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Substance-Related Disorders

Related studies from across the Substance-Related Disorders family.

Questions about Substance Use Disorder

How do just-in-time adaptive interventions help adolescents with substance use problems?

Just-in-time adaptive interventions (JITAIs) help adolescents by delivering personalized support at the exact moment they face risk, using real-time data to improve engagement and reduce substance use.

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What mobile health apps help youth with mental health and substance use?

Mobile apps like Mind your Mate help youth reduce depression and alcohol use by offering peer support and real-time tools, though effectiveness varies by app type and user needs.

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Do sexual minority women have higher substance use rates than heterosexual women?

Research shows sexual minority women have higher rates of substance use and related disorders than heterosexual women, with bisexual women often facing the highest risk.

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How did Substance Use Disorders change among US high school students before and during the pandemic?

Substance use among US high school students decreased overall during the pandemic, but disparities widened for certain groups, including sexual minority youth and those experiencing racial/ethnic stress.

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Do sexual minority women have higher rates of Substance Use Disorders compared to heterosexual women?

Research confirms that sexual minority women have higher rates of substance use disorders than heterosexual women, with bisexual women often facing the highest risk.

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See all 5 questions about Substance Use Disorder →