Review examines type VII secretion system roles in Mycobacterium tuberculosis immune evasion
How tuberculosis bacteria hide from your immune system using special tools
This narrative review synthesizes evidence on Mycobacterium tuberculosis type VII secretion system (ESX-associated genes) functions. It desc…
Tuberculosis bacteria use secret tools to steal iron, hide inside your cells, and slip past immune guards to cause serious illness.
Retrospective study finds low resistance to key antibiotics in TB patients with UTIs
When TB Treatment Hits a Wall: The Hidden Bladder Problem
A retrospective cohort study of 1,151 bacterial strains from tuberculosis patients with urinary tract infections at a single hospital found …
Tuberculosis patients with urinary infections face drug-resistant bacteria, but a five-year hospital review reveals which antibiotics still …
Pooled Xpert MTB/RIF Ultra testing shows high specificity but reduced sensitivity compared to individual testing in Vietnamese adults with presumptive tuberculosis.
Could testing TB samples in groups save money while still catching most cases?
This cross-sectional study evaluated pooled versus individual Xpert MTB/RIF Ultra testing among 2,396 adults with presumptive tuberculosis i…
Testing tuberculosis samples in groups saved over $14,000 and cut test kit use by nearly half while still catching most infections.
qPCR shows higher MTB detection rate than AFB staining in granulomatous inflammation tissues
A Faster Way to Catch Hidden TB in Tissue Samples
A cohort study of 1,050 patients with granulomatous inflammation found qPCR had a higher MTB detection rate (63.43%) than AFB staining (26.2…
A modern DNA-based lab test is catching tuberculosis that the century-old stain has been missing — and it can flag drug resistance at the sa…
VPM1002 vaccine shows 50% efficacy against extrapulmonary TB in household contacts in phase 3 trial
New TB Vaccines Protect Kids From Hidden Infections
A phase 3 randomized trial in 12,717 healthy household contacts of TB patients in India compared VPM1002 and Immuvac vaccines to placebo ove…
These new shots might stop a specific, dangerous type of TB in kids, but they did not stop the most common form of the disease.
Metabolic profiles differ in memory T cells between TB progressors and non-progressors in Brazilian cohort
Your Immune System’s Hidden Fuel Source May Decide a TB Infection’s Fate
A proof-of-concept cohort study in Brazil examined immunometabolic profiles of Mtb-specific memory CD4+ T cells in individuals with remote l…
A specific cellular fuel source in memory immune cells may determine whether a person's tuberculosis infection stays silent or turns active.
Diabetes prevalence 22% in Ghanaian TB cohort, associated with older age and higher BMI
A Hidden Health Link Doctors Are Now Spotting in Tuberculosis Patients
A prospective cohort study of 204 adults with pulmonary tuberculosis in Ghana found 22.1% had diabetes, with 30 newly diagnosed. Diabetes wa…
Routine screening for diabetes during tuberculosis treatment is uncovering a silent, widespread connection that could reshape patient care.
Baseline differences observed in HBV-TB versus simple HBV patients receiving anti-tuberculosis treatment
TB Meds Can Wake Up Liver Virus
This retrospective cohort study examined 324 patients with hepatitis B and tuberculosis co-infection or simple hepatitis B infection. Baseli…
Treating the liver virus before starting TB medication stops dangerous liver flares.
Meta-analysis of 529 samples identifies 108 gene signatures for active tuberculosis diagnosis.
A new AI-powered method finds a clear "signature" of TB in your blood.
This meta-analysis of observational transcriptomic data from 529 samples evaluated host-derived transcriptional signatures for active tuberc…
A new AI method finds a clear signature of tuberculosis in your blood, paving the way for faster, more accurate tests for the world's deadli…
Willingness for new TB vaccine is 77% overall, higher in adolescents than adults in southern Mozambique.
A New TB Vaccine is Coming. Will People Actually Take It?
This mixed methods study surveyed 151 adults, adolescents, and caregivers in southern Mozambique regarding willingness to receive a new tube…
In places hit hardest by tuberculosis, most people are ready to say "yes" to a new vaccine that could save lives.
Sputum quality does not affect Xpert MTB/RIF Ultra accuracy for tuberculosis diagnosis in multi-country study
Does sputum quality matter for TB testing? A global study suggests maybe not.
An observational study of 1855 people with presumptive TB across 7 countries found Xpert MTB/RIF Ultra positivity was not independently asso…
A global study finds that sputum quality doesn't significantly affect the accuracy of a common TB test, with high sensitivity and specificit…
Updated recommendations issued for tuberculosis prevention, control, and elimination
Health officials release updated recommendations for tuberculosis prevention and control
A public health program has released updated recommendations for tuberculosis prevention, control, and elimination. The specific study type,…
Health officials released updated recommendations to guide tuberculosis prevention and control efforts.