Narrative review links ceramide elevations to major depressive disorder and suicidal vulnerability.
Fatty Acids in Blood May Signal Depression Risk
This narrative review examines circulating ceramide species in major depressive disorder, treatment-resistant depression, and suicidal vulne…
Your body's fat levels might hold the key to understanding why some depression cases are so hard to treat.
Multi-omics data integration in Spanish psychiatric patients and controls
Scientists Are Building a Mental Health Database That Could Change Treatment Forever
This cohort study in Spain involved over 4,400 participants, including approximately 2,300 psychiatric patients and 2,100 controls. The rese…
This project could finally help doctors match the right treatment to the right patient, reducing the trial-and-error that many people face t…
FDA Approves Spravato (esketamine) for Treatment-Resistant Depression and Depressive Symptoms with Acute Suicidal Ideation in Adults
The FDA approved a new nasal spray called Spravato for severe depression.
The FDA approved Spravato (esketamine) for treatment-resistant depression in adults as monotherapy or with an oral antidepressant, and for d…
FDA approved a new nasal spray for severe depression when other treatments fail or when patients face acute suicidal thoughts.
PETRUSHKA decision-support tool reduced treatment discontinuation and improved symptoms in major depressive disorder
The Algorithm That Helps Doctors Pick the Right Antidepressant for You
This randomized clinical trial evaluated an evidence-based clinical decision-support system called PETRUSHKA against usual care in adults wi…
A new web-based tool helps doctors pick the right antidepressant, cutting discontinuation rates by nearly 40% and helping patients stay on t…
Meta-analysis finds gamma neuromodulation benefits in schizophrenia and major depressive disorder
Gamma neuromodulation showed symptom improvements in schizophrenia and depression in this review
This systematic review and meta-analysis synthesizes evidence on gamma neuromodulation for neuropsychiatric disorders. It reports moderate i…
Gamma neuromodulation improved positive and negative symptoms, anxiety, and thinking skills in schizophrenia while reducing depression in ma…
Mendelian randomization suggests loneliness causally increases schizophrenia and major depressive disorder risk.
Feeling Alone May Quietly Rewire Your Mental Health
This Mendelian randomization study investigated the causal relationship between loneliness and severe mental illness, including schizophreni…
Loneliness may directly raise the risk of schizophrenia and depression by changing body chemistry through inflammation, affecting millions o…
Internet-based CBT relapse predictors in remitted major depressive disorder patients
For those who beat depression with online therapy, what risks relapse and how to stay well?
This secondary analysis of a randomized controlled trial examined relapse in 83 remitted patients with major depressive disorder over 12 mon…
After beating depression with online therapy, about one-third of people relapse within a year, but finishing the program and seeking care wh…
Medically supervised ketogenic diet shows preliminary efficacy for moderate to severe major depressive disorder in a pilot trial.
Ketogenic Diet May Ease Severe Depression
This open-label, single-arm pilot feasibility trial evaluated a medically supervised ketogenic diet (MSKD) in 11 individuals with moderate t…
A low-carb, high-fat diet helped most participants maintain ketosis and showed promise for treating moderate to severe depression in a new p…
Sex-specific exposome components influence vulnerability to Major Depressive Disorder in women.
Why Women Get Sicker From Stress
This mini-narrative review examines sex-specific exposome components, including environmental and social exposures, neuroendocrine signaling…
Women face nearly double the lifetime risk of depression because environmental toxins and early-life stress permanently alter brain chemistr…
Chronic pain linked to 7.5-fold increase in severe depressive symptoms in UK Biobank analysis
Does chronic pain make depression worse? New data says yes, and the link goes both ways.
An observational study of 142,688 UK Biobank participants found chronic pain associated with a 7.50-fold increase in severe depressive sympt…
Chronic pain makes depression worse and depression increases pain risk, creating a two-way link that affects mood, focus, and appetite.
Group-based TSC intervention mediates improvements in depression and anxiety via insomnia severity in adults with MDD.
Did fixing sleep actually help depression, or was it just how patients felt about their rest?
This secondary analysis of a randomized controlled trial examined 152 adults with major depressive disorder receiving a group-based Transdia…
Feeling like sleep improved drove the real gains in depression and anxiety, proving that how patients perceive their rest matters more than …
Seltorexant vs Quetiapine-XR for MDD: Similar Discontinuation, Numeric MADRS Benefit at Lower Dose
New Drug Helps Depression When Sleep Is Lost
An exploratory phase 2 RCT compared adjunctive seltorexant (20/40 mg) to quetiapine-XR (150/300 mg) in SSRI/SNRI-inadequate responders with …
A new sleep drug helps lift depression without the weight gain or dizziness often caused by older treatments for patients who struggle to re…