FDA Approves Auvelity (dextromethorphan/bupropion) for Major Depressive Disorder and Agitation in Alzheimer's
FDA approves new drug Auvelity for depression and Alzheimer's agitation.
The FDA approved Auvelity (dextromethorphan/bupropion) for major depressive disorder (MDD) and agitation associated with dementia due to Alz…
The FDA approved Auvelity for major depressive disorder and agitation in Alzheimer's disease. It combines two medicines into one pill. This …
Adjunctive JNJ-42165279 fails to improve depression in SSRI/SNRI inadequate responders
Early trial finds new drug did not help depression in patients already on antidepressants
This phase 2a double-blind RCT tested adjunctive JNJ-42165279 25 mg daily versus placebo in 153 adults with major depressive disorder with a…
A small early study found a new drug did not improve depression symptoms for patients already taking standard antidepressants.
Magnetic seizure therapy non-inferior to ECT for depression with better memory outcomes
Magnetic therapy matches standard shock therapy for depression but spares memory
This randomized non-inferiority trial compared magnetic seizure therapy (MST) with right unilateral ultra-brief ECT in 239 adults with major…
A new trial shows magnetic seizure therapy works as well as standard shock therapy for depression while causing far less memory loss in adul…
Text-message CBT treatment reduced generalized anxiety disorder symptoms in young adults compared to wait-list control
Text Message Therapy Reduces Anxiety Symptoms in Young Adults
This randomized clinical trial enrolled 103 young adults with generalized anxiety disorder or major depressive disorder.
A text message treatment for depression also significantly lowered anxiety symptoms in young adults compared to waiting for care.
Systematic review finds aerobic exercise improves executive function in adults with major depressive disorder
Aerobic exercise improves thinking skills in adults with major depression
This systematic review and three-level meta-analysis evaluated aerobic exercise in adults with major depressive disorder.
Adults with major depression who exercised regularly showed better focus and mental flexibility. This review found clear benefits for core t…
Infrared Thermography of Acupoints Shows Correlation with Depression Severity in Adolescents
Body heat scans could help diagnose teen depression
This prospective observational study of 108 adolescents (65 with MDD, 43 controls) found that infrared temperatures of specific acupoints co…
A new scan measures body heat on specific points to help doctors diagnose teen depression without needles or invasive blood tests for adoles…
Parental severe mental illness associated with reduced offspring cognitive and academic performance in large meta-analysis
Children of parents with mental illness face real cognitive hurdles now
This meta-analysis examined 1,586,339 offspring of parents with severe mental illnesses, including schizophrenia, bipolar disorder, and majo…
New research shows kids of parents with severe mental illness struggle with memory and thinking skills, but early help can make a big differ…
MDD polygenic scores show adolescence-specific effects on child depressive symptoms in Norwegian cohort
Teen Depression Linked to Genes That "Switch On" at Puberty
This cohort study of children from the Norwegian Mother, Father and Child Cohort assessed depressive symptoms at ages 8 and 14.
Your teen's depression risk may be written in their genes, but only becomes visible during puberty's hormonal storm.
Observational Study Links Latitude and Genetics to Seasonal Affective Disorder Risk in Adults
Winter Blues Tied to Genes and Where You Live
This primary research article analyzes data from 12,460 adults in the Australian Genetics of Depression Study.
Where you live and the genes you carry may shape how much winter drags down your mood — and it’s not just about sunlight.
Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients
Researchers report framework for psychosurgery in treatment-refractory cases
This narrative critical review synthesizes contemporary psychosurgery options for treatment-refractory psychiatric disorders.
A new framework proposes connectomic-guided psychosurgery for treatment-refractory OCD, depression, and related disorders, based on symptom …
Internet-delivered psychodynamic therapy versus cognitive behavioural therapy shows no difference for adolescent depression at 12-month
Two online therapies offer similar support for teen depression
This randomized controlled trial included 272 adolescents aged 15–19 with major depressive disorder receiving internet-delivered psychodynam…
Two online therapy types showed similar results for teens with major depressive disorder after twelve months of treatment.
Multimodal AI methods show 65–85% accuracy for Major Depressive Disorder compared to traditional diagnostic approaches
AI Can Spot Depression From Your Voice and Smartphone—But Is It Ready for Your Doctor?
This review analyzed 40 original studies published after 2015 in clinical and translational settings.
This research shows AI could make depression diagnosis faster and more objective, but it’s not ready for your doctor’s office just yet.
Questions about Major Depressive Disorder
Can text-message cognitive-behavioral therapy help reduce symptoms of major depressive disorder in young adults?
Yes, text-message CBT (CBT-txt) significantly reduces depressive symptoms in young adults with major depressive disorder, based on multiple randomized trials.
Full answer →Does adding JNJ-42165279 help people whose major depressive disorder did not improve on current antidepressants?
No, JNJ-42165279 did not improve depression in a clinical trial of people whose SSRI/SNRI was not working well enough.
Full answer →Is Auvelity the new FDA-approved medication for treating major depressive disorder in adults?
Yes, Auvelity (dextromethorphan/bupropion) is FDA-approved for treating major depressive disorder in adults.
Full answer →