Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD
Study protocol tests brain stimulation for depression with suicidal thoughts
This is a study protocol for a single-blind RCT of 56 adults with major depressive disorder and active suicidal ideation. The protocol descr…
A new brain stimulation treatment is being tested to reduce depression and suicidal thoughts in adults, using magnetic pulses over 10 sessio…
Inflammatory markers elevated in adolescent MDD with both self-injury and suicide attempts
Could a simple blood test help identify teens at highest risk for self-harm?
A retrospective cross-sectional study of 618 adolescent inpatients with MDD found those with comorbid non-suicidal self-injury and suicide a…
Teens with depression who self-harm and attempt suicide show distinct blood markers, offering a potential clue to identify those at highest …
LSD Microdosing Shows Mood Improvement in Major Depressive Disorder: Phase 2a Trial
Can microdosing LSD really boost mood in people with depression?
An open-label trial of microdosed LSD in major depressive disorder showed mood improvements on dosing days (p = 0.009 to 0.039) but no chang…
People with depression taking microdosed LSD for eight weeks reported feeling happier and more creative on dosing days while symptoms droppe…
Phase 2 Trial of Icalcaprant for MDD: Assessing Efficacy and Safety
Could This New Drug Help Ease Severe Depression Symptoms?
A Phase 2 trial is evaluating the efficacy and safety of oral Icalcaprant in 195 adults with MDD. Primary outcomes include changes in MADRS …
A new drug called Icalcaprant is being tested to see if it can help adults with major depressive disorder who are currently experiencing a m…
Serum Zinc and Iron Levels Reduced in MDD; Copper Levels Elevated
Could Missing Nutrients Be Worsening Your Depression?
Meta-analysis of 16 studies shows MDD patients have lower serum zinc (SMD = -0.62; 95% CI: -0.78 to -0.46) and iron (SMD = -0.36; 95% CI: -0…
People with depression often have lower zinc and iron but higher copper levels in their blood, suggesting nutrition plays a key role in mana…