Algorithm-guided treatments may improve depression outcomes versus usual care in adults
Algorithm-guided depression treatment may lead to faster recovery than usual care
A systematic review of 7 RCTs involving over 3,500 adults with major depressive disorder found algorithm-guided treatments (AGTs) were assoc…
A structured treatment plan for depression helped patients recover faster and more often than usual care in a review of over 3,500 adults.
PCSK9 inhibitor initiation associated with lower depression risk versus statins in hyperlipidemia
Could lowering cholesterol with a new drug also protect against new episodes of depression?
A population-based cohort study of 35,610 adults with hyperlipidemia found PCSK9 inhibitor initiation was associated with lower risk of inci…
Starting a new cholesterol drug might lower the risk of developing depression compared to standard statins, based on data from over 35,000 a…
Medication-free major depressive disorder associated with age-dependent accelerated structural brain aging compared to healthy controls
Medication-free depression linked to accelerated brain aging in older adults
This observational cross-sectional MRI analysis compared medication-free individuals with major depressive disorder in a current episode to …
Depression in older adults without medication shows accelerated brain aging, with the gap widening to nearly seven years by age 55.
Multivariate GWAS identifies 248 loci for internalizing disorder and 591 for major depressive disorder in millions of participants.
Millions of people studied to find genetic links to anxiety and depression.
This multivariate and multi-ancestry genome-wide association study analyzed millions of ancestrally diverse participants to investigate the …
A massive study of millions of people reveals that anxiety, depression, and PTSD share a common genetic foundation while also having unique …
Observational study examines antidepressant use patterns by sex and marital status in US adults
Survey examines antidepressant use among U.S. adults by sex and marital status
An observational study of US adults aged ≥20 years examined antidepressant use patterns by sex and marital status. The study did not report …
A new report looks at how antidepressant use among U.S. adults varies by sex and marital status, offering a snapshot of medication patterns …
Genetic study identifies 375 shared loci between major depression and multisite chronic pain
Genetic study finds shared genetic links between chronic pain and depression
A genetic association study in European-ancestry individuals found a high degree of polygenic overlap between major depressive disorder and …
A new genetic study reveals 375 shared DNA locations linking chronic pain and depression, highlighting two specific genes active in the brai…
Mindfulness meditation training modulates neural connectivity differently in healthy and depressed individuals
Can mindfulness meditation change your brain differently if you're depressed?
An interventional study of 86 subjects (51 healthy, 35 depressed) found that mindfulness meditation training modulated somatomotor network-r…
Mindfulness meditation rewired brain networks for body awareness differently in healthy people versus those with depression, and these chang…
FDA Approves Bupropion Hydrochloride Extended-Release Tablets (SR) (bupropion) for Major Depressive Disorder
FDA approves a new, longer-acting version of the antidepressant bupropion.
The FDA has approved Bupropion Hydrochloride Extended-Release Tablets (SR) for the treatment of major depressive disorder (MDD). Efficacy wa…
A new extended-release antidepressant now helps adults manage depression for up to 44 weeks following initial treatment.
Meta-analysis finds error processing generally comparable in MDD versus healthy controls
Does depression change how the brain catches mistakes? A new review suggests maybe not.
A systematic review and meta-analysis of 22 studies on error-related negativity (ERN) and 10 on error positivity (Pe) in major depressive di…
A review finds the brain's mistake-detection signals are mostly normal in depression, but one signal weakens in people with other mental hea…
Meta-analysis identifies distinct and shared amygdala connectivity patterns in major depression and bipolar disorder
Do depression and bipolar disorder show different brain wiring patterns?
A voxel-wise meta-analysis of neuroimaging studies compared amygdala functional connectivity in patients with major depressive disorder and …
Brain scans show depression and bipolar disorder have different wiring in memory areas but share abnormalities in emotion control regions.
Meta-analysis identifies two genomic loci associated with antidepressant non-response in 135,471 individuals
Why do antidepressants fail for some people? New genetic clues emerge.
A genome-wide association meta-analysis of 135,471 individuals prescribed antidepressants identified two novel genomic loci associated with …
Millions struggle to find working antidepressants, but new genetic data reveals why some fail and suggests other drug options for treatment …
Meta-analysis finds mixed MRI patterns in subgenual cingulate cortex in medication-free MDD patients
What does depression look like in the brain? The picture is complicated.
A systematic review and meta-analysis of 42 publications compared medication-free MDD patients to healthy controls using MRI. It found mixed…
Depression scans show mixed results for brain size and activity, but consistently reveal weaker connections in an emotional hub when the bra…