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Home › Conditions › Sleep Disorders, Intrinsic

Sleep Disorders, Intrinsic

Subtypes of Sleep Disorders, Intrinsic

Obstructive Sleep Apnea 28 Insomnia 27 Restless Legs Syndrome 6 Sleep-disordered breathing 3 Narcolepsy 2 Sleep apnea 2 Idiopathic Hypersomnia 1 Central sleep apnea 0

80 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sleep Disorders, Intrinsic

52 trials tracked for Sleep Disorders, Intrinsic: 19 in phase 3 or 4 and 4 with published results. The most-cited published study has 306 citations.

52Trials tracked
19Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 9 Phase 3 10 Phase 2 6 Phase 1 1 Other / NA 26
  1. Phase 3 Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities Completed · 306 cited
  2. Phase 3 The Healthy Patterns Sleep Study Completed · 70 cited
  3. Phase 3 Brain Function in Premenopausal Women Receiving Tamoxifen With or Without Ovarian Function Suppression for Early-Stage Breast Cancer on Clinical Trial IBCSG 24-02 Completed · 39 cited
  4. Phase 4 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Completed · 4 cited
  5. Phase 4 Characteristics of Sleep Patterns in Young Adults With and Without Insomnia Completed
  6. Phase 4 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed
Show 44 more trials
  1. Phase 4 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed
  2. Phase 4 Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Completed
  3. Phase 4 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed
  4. Phase 4 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed
  5. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  6. Phase 4 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed
  7. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  8. Phase 3 Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer Completed
  9. Phase 3 A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001) Completed
  10. Phase 3 Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Completed
  11. Phase 3 Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia Completed
  12. Phase 3 A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002) Completed
  13. Phase 3 The Effectiveness of Regular Exercise on Improving Sleep in Older Adults Completed
  14. Phase 2 Melatonin Supplements for Improving Sleep in Individuals With Hypertension Completed
  15. Phase 2 Yoga in Treating Sleep Disturbance in Cancer Survivors Completed
  16. Phase 2 Exploratory Subjective Sleep Study of a Prototype Nasal Dilator Completed
  17. Phase 2 Study of Sleep-maintenance Activity of 3 Doses of SKP-1041 Completed
  18. Phase 2 Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction Completed
  19. Phase 2 Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor Completed
  20. Phase 1 Light for Renal Transplant Recipients Having a Sleep-Wake Dysregulation Completed
  21. N/A Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia Completed
  22. N/A Non-Pharmacological Interventions on Sleep in Post-Acute Rehabilitation Completed
  23. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  24. N/A Zolpidem CR and Hospitalized Patients With Dementia Completed
  25. N/A WatchPAT Device Validation Study Compared to Polysomnography Completed
  26. N/A The Effect of Therapeutic Touch on Sleep and Anxiety Completed
  27. N/A Insomnia Self-Management in Heart Failure Completed
  28. N/A Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders Completed
  29. N/A Sleep Length and Circadian Regulation in Humans Completed
  30. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes Completed
  31. N/A Sleep Specialty Consultation: Improving Management of Sleep Disorders Completed
  32. N/A Three Different Programs of Paced Breathing in Treating Hot Flashes in Women Completed
  33. N/A Brief Behavioral Therapy in Improving Sleep Disorders in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy Completed
  34. N/A Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer Completed
  35. N/A Remote Guided Caffeine Reduction Completed
  36. N/A Enhancing Sleep Quality for Nursing Home Residents With Dementia Completed
  37. N/A EEG Biofeedback Therapy as an Adjunct Treatment for PTSD Completed
  38. N/A PASCONAL NERVENTROPFEN in the Treatment of Nervous Diseases Completed
  39. N/A Glutathione and Health With Post-Polio Syndrome Completed
  40. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer Completed
  41. N/A Light Therapy for PD - Dose Selection Completed
  42. N/A Yoga or Educational Wellness Class for Women With Stage I, Stage II, or Stage III Breast Cancer Undergoing Chemotherapy Completed
  43. N/A Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) Completed
  44. N/A Efficacy of a Brief Nightmare Treatment for Veterans Completed

Showing the 50 most-cited and recently-updated of 52 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep Disorders, Intrinsic: what the trials found

Pharmacological interventions demonstrate varied efficacy in managing sleep parameters. Eszopiclone 7 and Zolpidem 8 are established treatments. Specifically, Eszopiclone has been utilized in clinical settings 7, while Zolpidem is an established intervention for sleep disorders 8.

Esmirtazapine shows significant improvements in several sleep metrics; it significantly increased Total Sleep Time (TST) 18, reduced Wake Time After Sleep Onset (WASO) 18, and improved Alertness at Awakening, Feeling Full of Energy, and Ability to Work/Function 19. Polysomnography measurements with Eszopiclone showed significant improvements in WASO 17 and Latency to Persistent Sleep 17, alongside changes in Total Sleep Time 17.

Other pharmacological agents show specific effects: Pregabalin significantly reduced Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22. Circadin showed significant improvements in Total Sleep Time 13 and Sleep Latency 13. Milnacipran showed a statistically significant improvement in Sleep Efficiency (SE) 9, though it did not significantly impact the Number of Awakenings After Sleep Onset (NAASO) 9 or Wake After Sleep Onset (WASO) 9.

Non-pharmacological and other interventions include armodafinil, which showed a significant improvement in Clinical Global Impression of Change (CGI-C) 11 and the Epworth Sleepiness Scale (ESS) 11, though it did not significantly change Maintenance of Wakefulness Test (MWT) scores 11. Stribild was associated with improvements in Sleep Disorder Scores 6.

Other interventions, such as Mometasone furoate nasal spray 12 and Tamoxifen 15, did not show statistically significant changes in primary sleep metrics like Apnea-Hypopnea Index or cognitive function respectively.

Recent results — preliminary, needs further review

  • Therapeutic touch was associated with improved Visual Analogue Scale scores (p=0.001) and improved Sleep Duration and Sleep Onset Difficulties (p=0.040) 2.
  • Exercise intervention is currently being studied as a potential treatment 1.
  • SunRay Light Boxes are under investigation for sleep disorders 3.

For the clinician treating this condition

  • Esmirtazapine provides significant improvements in TST, WASO, and subjective measures of alertness and functionality [17, 18, 19].
  • Pregabalin is effective for reducing Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22.
  • Circadin significantly improves both Total Sleep Time and Sleep Latency 13.
  • Armodafinil shows significant improvements in subjective sleepiness (ESS) and overall clinical impression of change 11.

AI synthesis of 15 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Cardiology Meta-analysis
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
Jun 2, 2026
Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
ENT (Otolaryngology) Meta-analysis
Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients Radiation for head and neck cancer may raise sleep apnea risk
This scoping review with exploratory meta-analysis of 13 studies found no significant association between radiotherapy or chemotherapy and i…
A review of 13 studies suggests a possible link between radiation for head and neck cancer and mild sleep apnea, but the evidence is too wea…
Jun 2, 2026
Nurse-administered acupressure reduces PSQI scores by MD -7.61 in menopausal insomnia
Physical Medicine & Rehab Meta-analysis
Nurse-administered acupressure reduces PSQI scores by MD -7.61 in menopausal insomnia Non-drug treatments improve sleep in women after menopause
This meta-analysis of randomized controlled trials in 1648 women after natural menopause found that non-pharmacological interventions, parti…
A large review of trials shows non-drug methods like therapy and exercise significantly improve sleep scores for post-menopausal women.
Jun 1, 2026
Non-surgical weight loss reduces AHI by 11.10 in adults with obstructive sleep apnoea
Primary Care & Family Medicine Meta-analysis
Non-surgical weight loss reduces AHI by 11.10 in adults with obstructive sleep apnoea Non-surgical weight loss lowers sleep apnea severity and blood pressure in adults
This systematic review and meta-analysis evaluated non-surgical weight loss interventions in adults with obstructive sleep apnoea. The poole…
Non-surgical weight loss significantly reduced sleep apnea severity and blood pressure in adults, though long-term results remain uncertain.
Jun 1, 2026
Sleep problems affect 61% of adults with rheumatoid arthritis in WHO EMRO countries
Psychiatry Meta-analysis
Sleep problems affect 61% of adults with rheumatoid arthritis in WHO EMRO countries Sleep troubles hit 60.9% of adults with rheumatoid arthritis in the Eastern Mediterranean
This systematic review and meta-analysis of 2,315 adults with rheumatoid arthritis in WHO EMRO countries found sleep-related problems are hi…
Sleep problems affect more than six out of ten adults with rheumatoid arthritis in the Eastern Mediterranean. Depression and pain are the st…
Frontiers May 30, 2026
Sleep and circadian rhythm alterations associate with prolonged ventilation and worse outcomes in adult ICU patients
Neurology Sys. Review
Sleep and circadian rhythm alterations associate with prolonged ventilation and worse outcomes in adult ICU patients Disrupted sleep in the ICU linked to worse outcomes
This narrative review examines sleep and circadian rhythm alterations in adult ICU patients. The authors synthesize associations between dis…
Poor sleep in the ICU is tied to longer ventilation, delirium, and lasting health problems. New review highlights the hidden cost of broken …
Frontiers May 29, 2026
Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia
Neurology Meta-analysis
Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia Tuina combination therapies beat oral medication for insomnia in this exploratory review
This systematic review and network meta-analysis evaluated Tuina-based combination therapies against oral medication in 2,663 subjects with …
Combining Tuina with breath guiding, music, or foot baths worked better than oral medication for insomnia in this review of 2,663 patients.
Frontiers May 28, 2026
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Drug Pipeline Sys. Review
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Frontiers May 25, 2026
MAD shows modest BP benefit over CPAP in OSA patients
Neurology Meta-analysis
MAD shows modest BP benefit over CPAP in OSA patients Mandibular advancement devices lower blood pressure better than CPAP for some patients
A meta-analysis found mandibular advancement devices slightly outperform CPAP for lowering daytime blood pressure in obstructive sleep apnea…
For patients with obstructive sleep apnea, a new analysis shows mandibular advancement devices reduced daytime blood pressure more than CPAP…
Frontiers May 25, 2026
Meta-analysis finds probiotics modestly improve sleep quality with low certainty
Neurology Meta-analysis
Meta-analysis finds probiotics modestly improve sleep quality with low certainty Probiotics may modestly improve sleep quality, review finds
This meta-analysis of 39 trials (4094 participants) found that probiotic supplementation modestly improved global sleep quality (MD -0.71 on…
A meta-analysis of 39 trials found probiotics slightly improved sleep quality and daytime function, but effects were small and evidence unce…
Frontiers May 23, 2026
Meta-analysis identifies genetic loci and biomarkers for restless legs syndrome in over 1.3 million individuals
Genetics & Precision Medicine Meta-analysis
Meta-analysis identifies genetic loci and biomarkers for restless legs syndrome in over 1.3 million individuals Genetic study links over 100 conditions to restless legs syndrome
This meta-analysis synthesizes genome-wide and phenome-wide association analyses from UK Biobank and All of Us cohorts involving more than 1…
A massive genetic analysis connects restless legs syndrome to more than 100 other diseases, lifestyle factors, and biomarkers in over 1.3 mi…
medRxiv May 23, 2026
Delayed arousal timing links to higher mortality in sleep apnea patients
Pulmonology & Critical Care Meta-analysis
Delayed arousal timing links to higher mortality in sleep apnea patients Timing of breathing pauses predicts death risk in obstructive sleep apnea
A meta-analysis found that each one-second delay in post-apnea arousal peak time was associated with increased all-cause and cardiovascular …
New analysis shows how late a breathing pause wakes you up predicts higher death risk for men with obstructive sleep apnea.
medRxiv May 21, 2026

Questions about Sleep Disorders, Intrinsic

How do sleep disorders impact gait quality and fall risk in older adults?

Sleep disorders in older adults are linked to worse balance control and a higher chance of falling, even if walking speed does not change.

Full answer →
Are sleep problems linked to a higher risk of falling in older adults?

Yes, sleep problems are linked to a higher risk of falling in older adults, likely due to impaired gait quality and balance.

Full answer →
Can cannabis use affect my sleep disorders based on genetic studies?

Genetic studies show that cannabis use and sleep disorders share specific genetic risks, particularly for insomnia and nighttime activity levels.

Full answer →