How many clinical trials are tracked for Sleep Disorders, Intrinsic?

52 trials are tracked, 4 with published results.

Sleep Disorders, Intrinsic Research

Sleep Disorders, Intrinsic: what the trials found

Pharmacological interventions demonstrate varied efficacy in managing sleep parameters. Eszopiclone ⁷ and Zolpidem ⁸ are established treatments. Specifically, Eszopiclone has been utilized in clinical settings ⁷, while Zolpidem is an established intervention for sleep disorders ⁸.

Esmirtazapine shows significant improvements in several sleep metrics; it significantly increased Total Sleep Time (TST) ¹⁸, reduced Wake Time After Sleep Onset (WASO) ¹⁸, and improved Alertness at Awakening, Feeling Full of Energy, and Ability to Work/Function ¹⁹. Polysomnography measurements with Eszopiclone showed significant improvements in WASO ¹⁷ and Latency to Persistent Sleep ¹⁷, alongside changes in Total Sleep Time ¹⁷.

Other pharmacological agents show specific effects: Pregabalin significantly reduced Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) ²². Circadin showed significant improvements in Total Sleep Time ¹³ and Sleep Latency ¹³. Milnacipran showed a statistically significant improvement in Sleep Efficiency (SE) ⁹, though it did not significantly impact the Number of Awakenings After Sleep Onset (NAASO) ⁹ or Wake After Sleep Onset (WASO) ⁹.

Non-pharmacological and other interventions include armodafinil, which showed a significant improvement in Clinical Global Impression of Change (CGI-C) ¹¹ and the Epworth Sleepiness Scale (ESS) ¹¹, though it did not significantly change Maintenance of Wakefulness Test (MWT) scores ¹¹. Stribild was associated with improvements in Sleep Disorder Scores ⁶.

Other interventions, such as Mometasone furoate nasal spray ¹² and Tamoxifen ¹⁵, did not show statistically significant changes in primary sleep metrics like Apnea-Hypopnea Index or cognitive function respectively.

For the clinician treating this condition

Esmirtazapine provides significant improvements in TST, WASO, and subjective measures of alertness and functionality [17, 18, 19].
Pregabalin is effective for reducing Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) ²².
Circadin significantly improves both Total Sleep Time and Sleep Latency ¹³.
Armodafinil shows significant improvements in subjective sleepiness (ESS) and overall clinical impression of change ¹¹.

AI synthesis of 15 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.