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Home › Conditions › Sleep Disorders, Intrinsic

Sleep Disorders, Intrinsic

Subtypes of Sleep Disorders, Intrinsic

Insomnia 40 Obstructive Sleep Apnea 38 Restless Legs Syndrome 6 Sleep apnea 5 Sleep-disordered breathing 4 Narcolepsy 2 Idiopathic Hypersomnia 1 Central sleep apnea 0

108 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sleep Disorders, Intrinsic

52 trials tracked for Sleep Disorders, Intrinsic: 19 in phase 3 or 4 and 4 with published results. The most-cited published study has 310 citations.

52Trials tracked
19Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 9 Phase 3 10 Phase 2 6 Phase 1 1 Other / NA 26
  1. Phase 3 Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities Completed · 310 cited
  2. Phase 3 The Healthy Patterns Sleep Study Completed · 72 cited
  3. Phase 3 Brain Function in Premenopausal Women Receiving Tamoxifen With or Without Ovarian Function Suppression for Early-Stage Breast Cancer on Clinical Trial IBCSG 24-02 Completed · 39 cited
  4. Phase 4 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Completed · 5 cited
  5. Phase 4 Characteristics of Sleep Patterns in Young Adults With and Without Insomnia Completed
  6. Phase 4 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed
Show 44 more trials
  1. Phase 4 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed
  2. Phase 4 Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Completed
  3. Phase 4 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed
  4. Phase 4 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed
  5. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  6. Phase 4 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed
  7. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  8. Phase 3 Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer Completed
  9. Phase 3 A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001) Completed
  10. Phase 3 Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Completed
  11. Phase 3 Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia Completed
  12. Phase 3 A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002) Completed
  13. Phase 3 The Effectiveness of Regular Exercise on Improving Sleep in Older Adults Completed
  14. Phase 2 Melatonin Supplements for Improving Sleep in Individuals With Hypertension Completed
  15. Phase 2 Yoga in Treating Sleep Disturbance in Cancer Survivors Completed
  16. Phase 2 Exploratory Subjective Sleep Study of a Prototype Nasal Dilator Completed
  17. Phase 2 Study of Sleep-maintenance Activity of 3 Doses of SKP-1041 Completed
  18. Phase 2 Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction Completed
  19. Phase 2 Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor Completed
  20. Phase 1 Light for Renal Transplant Recipients Having a Sleep-Wake Dysregulation Completed
  21. N/A Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia Completed
  22. N/A Non-Pharmacological Interventions on Sleep in Post-Acute Rehabilitation Completed
  23. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  24. N/A Zolpidem CR and Hospitalized Patients With Dementia Completed
  25. N/A WatchPAT Device Validation Study Compared to Polysomnography Completed
  26. N/A The Effect of Therapeutic Touch on Sleep and Anxiety Completed
  27. N/A Insomnia Self-Management in Heart Failure Completed
  28. N/A Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders Completed
  29. N/A Sleep Length and Circadian Regulation in Humans Completed
  30. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes Completed
  31. N/A Sleep Specialty Consultation: Improving Management of Sleep Disorders Completed
  32. N/A Three Different Programs of Paced Breathing in Treating Hot Flashes in Women Completed
  33. N/A Brief Behavioral Therapy in Improving Sleep Disorders in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy Completed
  34. N/A Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer Completed
  35. N/A Remote Guided Caffeine Reduction Completed
  36. N/A Enhancing Sleep Quality for Nursing Home Residents With Dementia Completed
  37. N/A EEG Biofeedback Therapy as an Adjunct Treatment for PTSD Completed
  38. N/A PASCONAL NERVENTROPFEN in the Treatment of Nervous Diseases Completed
  39. N/A Glutathione and Health With Post-Polio Syndrome Completed
  40. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer Completed
  41. N/A Light Therapy for PD - Dose Selection Completed
  42. N/A Yoga or Educational Wellness Class for Women With Stage I, Stage II, or Stage III Breast Cancer Undergoing Chemotherapy Completed
  43. N/A Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) Completed
  44. N/A Efficacy of a Brief Nightmare Treatment for Veterans Completed

Showing the 50 most-cited and recently-updated of 52 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep Disorders, Intrinsic: what the trials found

Pharmacological interventions demonstrate varied efficacy in managing sleep parameters. Eszopiclone 7 and Zolpidem 8 are established treatments. Specifically, Eszopiclone has been utilized in clinical settings 7, while Zolpidem is an established intervention for sleep disorders 8.

Esmirtazapine shows significant improvements in several sleep metrics; it significantly increased Total Sleep Time (TST) 18, reduced Wake Time After Sleep Onset (WASO) 18, and improved Alertness at Awakening, Feeling Full of Energy, and Ability to Work/Function 19. Polysomnography measurements with Eszopiclone showed significant improvements in WASO 17 and Latency to Persistent Sleep 17, alongside changes in Total Sleep Time 17.

Other pharmacological agents show specific effects: Pregabalin significantly reduced Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22. Circadin showed significant improvements in Total Sleep Time 13 and Sleep Latency 13. Milnacipran showed a statistically significant improvement in Sleep Efficiency (SE) 9, though it did not significantly impact the Number of Awakenings After Sleep Onset (NAASO) 9 or Wake After Sleep Onset (WASO) 9.

Non-pharmacological and other interventions include armodafinil, which showed a significant improvement in Clinical Global Impression of Change (CGI-C) 11 and the Epworth Sleepiness Scale (ESS) 11, though it did not significantly change Maintenance of Wakefulness Test (MWT) scores 11. Stribild was associated with improvements in Sleep Disorder Scores 6.

Other interventions, such as Mometasone furoate nasal spray 12 and Tamoxifen 15, did not show statistically significant changes in primary sleep metrics like Apnea-Hypopnea Index or cognitive function respectively.

Recent results — preliminary, needs further review

  • Therapeutic touch was associated with improved Visual Analogue Scale scores (p=0.001) and improved Sleep Duration and Sleep Onset Difficulties (p=0.040) 2.
  • Exercise intervention is currently being studied as a potential treatment 1.
  • SunRay Light Boxes are under investigation for sleep disorders 3.

For the clinician treating this condition

  • Esmirtazapine provides significant improvements in TST, WASO, and subjective measures of alertness and functionality [17, 18, 19].
  • Pregabalin is effective for reducing Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22.
  • Circadin significantly improves both Total Sleep Time and Sleep Latency 13.
  • Armodafinil shows significant improvements in subjective sleepiness (ESS) and overall clinical impression of change 11.

AI synthesis of 15 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review and meta-analysis of insomnia prevalence and risk factors in patients with coronary heart disease
Psychiatry Meta-analysis
Systematic review and meta-analysis of insomnia prevalence and risk factors in patients with coronary heart disease Half of All Heart Disease Patients Can't Sleep — Here's Why That's Dangerous
This systematic review and meta-analysis evaluated insomnia prevalence and associated factors in 5,928 patients with coronary heart disease.
Half of all heart disease patients suffer from insomnia, a common but rarely treated condition linked to depression, anxiety, and diabetes.
Frontiers Apr 14, 2026
CPAP adherence linked to improved atherogenic lipid profiles in adults with moderate-severe OSAS
Rheumatology Cohort
CPAP adherence linked to improved atherogenic lipid profiles in adults with moderate-severe OSAS Your CPAP Machine May Be Protecting Your Heart Too
A single-center cohort study of 104 adults with moderate-severe OSAS found that adherent CPAP therapy (≥4 h/night on ≥70% of nights) was ass…
More time with low oxygen at night worsens cholesterol balance, but CPAP therapy helps reverse this heart risk in sleep apnea patients.
Frontiers Apr 14, 2026
Group-based TSC intervention mediates improvements in depression and anxiety via insomnia severity in adults with MDD
Psychiatry RCT
Group-based TSC intervention mediates improvements in depression and anxiety via insomnia severity in adults with MDD Did fixing sleep actually help depression, or was it just how patients felt about their rest?
This secondary analysis of a randomized controlled trial examined 152 adults with major depressive disorder receiving a group-based Transdia…
Feeling like sleep improved drove the real gains in depression and anxiety, proving that how patients perceive their rest matters more than …
Apr 13, 2026
Inflammatory-metabolic indices show association with obstructive sleep apnea risk in observational cohorts
Neurology Cohort
Inflammatory-metabolic indices show association with obstructive sleep apnea risk in observational cohorts A simple blood test clue for sleep apnea risk
A cross-sectional observational study of a Chinese clinical cohort (n=300) and US NHANES participants (n=4,423) found several inflammatory-m…
New blood test scores may help spot sleep apnea risk in people who can't easily access overnight sleep studies.
Frontiers Apr 13, 2026
Machine learning model using 15-item questionnaire shows high accuracy for obstructive sleep apnea screening
ENT (Otolaryngology) Cohort
Machine learning model using 15-item questionnaire shows high accuracy for obstructive sleep apnea screening A Simple 15-Question Quiz Could Transform Sleep Apnea Diagnosis
A mixed-methods study of 4,036 participants found that a gradient boosting prediction model using a 15-item questionnaire achieved AUCs of 0…
This isn't just another online quiz—it's a smarter, data-driven screening tool that could help doctors identify a dangerous sleep disorder w…
Frontiers Apr 12, 2026
Genetically predicted obstructive sleep apnea liability associated with increased myocardial infarction risk in Mendelian randomization analysis
Cardiology
Genetically predicted obstructive sleep apnea liability associated with increased myocardial infarction risk in Mendelian randomization analysis Your Sleep Apnea May Be a Direct Threat to Your Heart
This Mendelian randomization analysis suggests a causal association between genetically predicted obstructive sleep apnea (OSA) liability an…
A new genetic study confirms sleep apnea directly raises your risk of a heart attack, proving the link is real and more complex than previou…
medRxiv Apr 12, 2026
Diary intervention improves sleep and reduces stress in critically ill children and their parents
Psychiatry RCT
Diary intervention improves sleep and reduces stress in critically ill children and their parents Could a simple diary help critically ill children sleep better and reduce family stress?
A single-blind randomized controlled trial of 94 PICU patient-parent dyads found that a diary intervention significantly improved children's…
A simple diary helped critically ill children sleep better and reduced anxiety and depression in their parents for months after leaving the …
Apr 9, 2026
DISEDS improves polysomnographic outcomes in pediatric OSA, with greater effect in Trisomy 21
Pediatrics Meta-analysis
DISEDS improves polysomnographic outcomes in pediatric OSA, with greater effect in Trisomy 21 Surgery guided by sleep endoscopy improves breathing measures in children with sleep apnea
A meta-analysis of 41 observational studies in 3,404 pediatric OSA patients found DISE-directed surgery was associated with significant impr…
Surgery guided by sleep endoscopy improved breathing scores for over 3,400 children with sleep apnea, with even greater gains for those with…
Apr 9, 2026
Breathwork reduces anxiety, depression, and stress in paramedic students in 12-week RCT
Psychiatry RCT
Breathwork reduces anxiety, depression, and stress in paramedic students in 12-week RCT Breathwork practice may reduce stress and anxiety in student paramedics
A single-blind RCT of 98 student paramedics found that a 12-week structured breathwork protocol (A52 Breath Method) significantly reduced an…
A 12-week breathing routine helped student paramedics lower stress, anxiety, and depression while boosting resilience without any reported s…
Apr 9, 2026
NoSAS score diagnostic accuracy for obstructive sleep apnea screening
Diabetes & Endocrinology Meta-analysis
NoSAS score diagnostic accuracy for obstructive sleep apnea screening NoSAS score shows mixed accuracy for screening obstructive sleep apnea across severity levels
This systematic review and meta-analysis evaluated the diagnostic accuracy of the Neck Circumference, Obesity, Snoring, Age, and Sex (NoSAS)…
The NoSAS score misses many severe sleep apnea cases, catching only 82% of them while failing to rule out half of those without the conditio…
Apr 9, 2026
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants
Neurology
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants Can computer programs match human experts at reading your sleep data?
This study evaluated machine-learning models for sleep stage classification, arousal detection, and respiratory event detection using overni…
Smart computer models can match human experts at reading sleep data for stages and wake-ups, though they still lag behind humans when spotti…
medRxiv Apr 9, 2026
Liraglutide reduces OSA severity in patients with COPD and obesity in exploratory analysis
Diabetes & Endocrinology RCT
Liraglutide reduces OSA severity in patients with COPD and obesity in exploratory analysis Could a weight loss drug help people with COPD breathe easier at night?
A secondary exploratory analysis of a 40-week RCT in 40 patients with COPD and overweight/obesity found liraglutide (3.0 mg) significantly r…
A weight loss drug reduced breathing pauses and oxygen drops for people with COPD and sleep apnea, improving general health while day-time s…
Apr 8, 2026

Questions about Sleep Disorders, Intrinsic

How do sleep disorders impact gait quality and fall risk in older adults?

Sleep disorders in older adults are linked to worse balance control and a higher chance of falling, even if walking speed does not change.

Full answer →
Are sleep problems linked to a higher risk of falling in older adults?

Yes, sleep problems are linked to a higher risk of falling in older adults, likely due to impaired gait quality and balance.

Full answer →
Can cannabis use affect my sleep disorders based on genetic studies?

Genetic studies show that cannabis use and sleep disorders share specific genetic risks, particularly for insomnia and nighttime activity levels.

Full answer →