Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Sleep Disorders, Intrinsic

Sleep Disorders, Intrinsic

Subtypes of Sleep Disorders, Intrinsic

Insomnia 40 Obstructive Sleep Apnea 38 Restless Legs Syndrome 6 Sleep apnea 5 Sleep-disordered breathing 4 Narcolepsy 2 Idiopathic Hypersomnia 1 Central sleep apnea 0

108 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sleep Disorders, Intrinsic

52 trials tracked for Sleep Disorders, Intrinsic: 19 in phase 3 or 4 and 4 with published results. The most-cited published study has 310 citations.

52Trials tracked
19Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 9 Phase 3 10 Phase 2 6 Phase 1 1 Other / NA 26
  1. Phase 3 Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities Completed · 310 cited
  2. Phase 3 The Healthy Patterns Sleep Study Completed · 72 cited
  3. Phase 3 Brain Function in Premenopausal Women Receiving Tamoxifen With or Without Ovarian Function Suppression for Early-Stage Breast Cancer on Clinical Trial IBCSG 24-02 Completed · 39 cited
  4. Phase 4 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Completed · 5 cited
  5. Phase 4 Characteristics of Sleep Patterns in Young Adults With and Without Insomnia Completed
  6. Phase 4 Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome Completed
Show 44 more trials
  1. Phase 4 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed
  2. Phase 4 Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Completed
  3. Phase 4 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed
  4. Phase 4 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed
  5. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  6. Phase 4 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed
  7. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  8. Phase 3 Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer Completed
  9. Phase 3 A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001) Completed
  10. Phase 3 Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD Completed
  11. Phase 3 Effects Of Pregabalin (Lyrica) On Sleep Maintenance In Subjects With Fibromyalgia Completed
  12. Phase 3 A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002) Completed
  13. Phase 3 The Effectiveness of Regular Exercise on Improving Sleep in Older Adults Completed
  14. Phase 2 Melatonin Supplements for Improving Sleep in Individuals With Hypertension Completed
  15. Phase 2 Yoga in Treating Sleep Disturbance in Cancer Survivors Completed
  16. Phase 2 Exploratory Subjective Sleep Study of a Prototype Nasal Dilator Completed
  17. Phase 2 Study of Sleep-maintenance Activity of 3 Doses of SKP-1041 Completed
  18. Phase 2 Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction Completed
  19. Phase 2 Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor Completed
  20. Phase 1 Light for Renal Transplant Recipients Having a Sleep-Wake Dysregulation Completed
  21. N/A Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia Completed
  22. N/A Non-Pharmacological Interventions on Sleep in Post-Acute Rehabilitation Completed
  23. N/A TatchSleep as a Tool to Aid in Sleep Apnea Analysis Completed
  24. N/A Zolpidem CR and Hospitalized Patients With Dementia Completed
  25. N/A WatchPAT Device Validation Study Compared to Polysomnography Completed
  26. N/A The Effect of Therapeutic Touch on Sleep and Anxiety Completed
  27. N/A Insomnia Self-Management in Heart Failure Completed
  28. N/A Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders Completed
  29. N/A Sleep Length and Circadian Regulation in Humans Completed
  30. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Part 1: Implementation Health Outcomes Completed
  31. N/A Sleep Specialty Consultation: Improving Management of Sleep Disorders Completed
  32. N/A Three Different Programs of Paced Breathing in Treating Hot Flashes in Women Completed
  33. N/A Brief Behavioral Therapy in Improving Sleep Disorders in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy Completed
  34. N/A Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer Completed
  35. N/A Remote Guided Caffeine Reduction Completed
  36. N/A Enhancing Sleep Quality for Nursing Home Residents With Dementia Completed
  37. N/A EEG Biofeedback Therapy as an Adjunct Treatment for PTSD Completed
  38. N/A PASCONAL NERVENTROPFEN in the Treatment of Nervous Diseases Completed
  39. N/A Glutathione and Health With Post-Polio Syndrome Completed
  40. N/A Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer Completed
  41. N/A Light Therapy for PD - Dose Selection Completed
  42. N/A Yoga or Educational Wellness Class for Women With Stage I, Stage II, or Stage III Breast Cancer Undergoing Chemotherapy Completed
  43. N/A Augmentation Trial of Prazosin for Post-Traumatic Stress Disorder (PTSD) Completed
  44. N/A Efficacy of a Brief Nightmare Treatment for Veterans Completed

Showing the 50 most-cited and recently-updated of 52 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sleep Disorders, Intrinsic: what the trials found

Pharmacological interventions demonstrate varied efficacy in managing sleep parameters. Eszopiclone 7 and Zolpidem 8 are established treatments. Specifically, Eszopiclone has been utilized in clinical settings 7, while Zolpidem is an established intervention for sleep disorders 8.

Esmirtazapine shows significant improvements in several sleep metrics; it significantly increased Total Sleep Time (TST) 18, reduced Wake Time After Sleep Onset (WASO) 18, and improved Alertness at Awakening, Feeling Full of Energy, and Ability to Work/Function 19. Polysomnography measurements with Eszopiclone showed significant improvements in WASO 17 and Latency to Persistent Sleep 17, alongside changes in Total Sleep Time 17.

Other pharmacological agents show specific effects: Pregabalin significantly reduced Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22. Circadin showed significant improvements in Total Sleep Time 13 and Sleep Latency 13. Milnacipran showed a statistically significant improvement in Sleep Efficiency (SE) 9, though it did not significantly impact the Number of Awakenings After Sleep Onset (NAASO) 9 or Wake After Sleep Onset (WASO) 9.

Non-pharmacological and other interventions include armodafinil, which showed a significant improvement in Clinical Global Impression of Change (CGI-C) 11 and the Epworth Sleepiness Scale (ESS) 11, though it did not significantly change Maintenance of Wakefulness Test (MWT) scores 11. Stribild was associated with improvements in Sleep Disorder Scores 6.

Other interventions, such as Mometasone furoate nasal spray 12 and Tamoxifen 15, did not show statistically significant changes in primary sleep metrics like Apnea-Hypopnea Index or cognitive function respectively.

Recent results — preliminary, needs further review

  • Therapeutic touch was associated with improved Visual Analogue Scale scores (p=0.001) and improved Sleep Duration and Sleep Onset Difficulties (p=0.040) 2.
  • Exercise intervention is currently being studied as a potential treatment 1.
  • SunRay Light Boxes are under investigation for sleep disorders 3.

For the clinician treating this condition

  • Esmirtazapine provides significant improvements in TST, WASO, and subjective measures of alertness and functionality [17, 18, 19].
  • Pregabalin is effective for reducing Wake After Sleep Onset (WASO) and Wake Time During Sleep (WTDS) 22.
  • Circadin significantly improves both Total Sleep Time and Sleep Latency 13.
  • Armodafinil shows significant improvements in subjective sleepiness (ESS) and overall clinical impression of change 11.

AI synthesis of 15 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
HGNS therapy improves subjective outcomes but shows limited cognitive benefit in OSA patients
Physical Medicine & Rehab RCT
HGNS therapy improves subjective outcomes but shows limited cognitive benefit in OSA patients Does better sleep with a nerve stimulator actually make your brain sharper, or just feel better?
A secondary analysis of a randomized crossover trial in 60 patients with moderate-severe OSA optimized on HGNS therapy found patient-reporte…
A nerve stimulator that fully treats sleep apnea improved how patients felt and snoring, but did not boost overall brain performance on stan…
Apr 8, 2026
Sleep Problems Associated With Impaired Gait Quality and Higher Fall Risk in Older Adults
Geriatrics & Aging
Sleep Problems Associated With Impaired Gait Quality and Higher Fall Risk in Older Adults Older adults reporting sleep problems had poorer walking quality and more falls in study
An observational study of 758 community-dwelling older adults found self-reported sleep problems were associated with lower daily-life gait …
Older adults with sleep trouble walked less steadily and fell nearly 50% more often than those who slept well, according to a new study.
medRxiv Apr 7, 2026
Two-week active tsDCS improved RLS symptoms and neurophysiological measures versus sham in a small RCT
Anesthesiology & Pain Medicine RCT
Two-week active tsDCS improved RLS symptoms and neurophysiological measures versus sham in a small RCT Could a two-week treatment ease restless legs and improve sleep for patients?
This randomized controlled trial evaluated active transcutaneous spinal cord direct current stimulation (tsDCS) versus sham stimulation in 3…
A two-week electrical stimulation treatment significantly eased restless legs symptoms and improved sleep quality compared to a fake treatme…
Apr 6, 2026
Meta-analysis of Stellate Ganglion Block shows improved sleep metrics in patients with sleep disturbances
Psychiatry Meta-analysis
Meta-analysis of Stellate Ganglion Block shows improved sleep metrics in patients with sleep disturbances Could a simple nerve block help you sleep longer and deeper?
This systematic review and meta-analysis evaluated seven studies involving patients who received a Stellate Ganglion Block (SGB) compared to…
Patients receiving a nerve block in the neck slept longer, fell asleep faster, and enjoyed deeper rest compared to those who did not receive…
Frontiers Apr 6, 2026
Interactive e-books and traditional education show comparable effectiveness for foundational cancer sleep management nurse training
Oncology RCT
Interactive e-books and traditional education show comparable effectiveness for foundational cancer sleep management nurse training Study compares e-book and traditional training for nurses on cancer sleep management
A cluster randomized controlled trial of 142 oncology nurses found both interactive e-books and traditional education significantly improved…
Interactive e-books and traditional classes both boosted nurses' confidence in helping cancer patients with sleep issues, though knowledge g…
Apr 5, 2026
PAP therapy reduces pulmonary arterial pressures in patients with severe OSA or OHS
Nutrition & Obesity Medicine Meta-analysis
PAP therapy reduces pulmonary arterial pressures in patients with severe OSA or OHS Breathing therapy linked to lower lung pressure in severe sleep apnea patients
A meta-analysis of 733 patients with obstructive sleep apnoea or obesity hypoventilation syndrome found PAP therapy was associated with a me…
Positive airway pressure therapy lowers lung artery pressure in severe sleep apnea patients, with the biggest drops seen in those who alread…
Apr 3, 2026
Progressive Muscle Relaxation May Reduce Pain and Improve Sleep After Open Heart Surgery
Anesthesiology & Pain Medicine RCT
Progressive Muscle Relaxation May Reduce Pain and Improve Sleep After Open Heart Surgery Relaxation technique may help reduce pain and improve sleep after heart surgery
A single-center, single-blind RCT of 60 patients undergoing open heart surgery found that twice-daily Progressive Muscle Relaxation (PMR) on…
A simple relaxation technique helped heart surgery patients cut pain from a 9 out of 10 to just 1.5 and sleep better within three days.
Apr 3, 2026
Mindfulness meditation training modulates neural connectivity differently in healthy and depressed individuals
Psychiatry
Mindfulness meditation training modulates neural connectivity differently in healthy and depressed individuals Can mindfulness meditation change your brain differently if you're depressed?
An interventional study of 86 subjects (51 healthy, 35 depressed) found that mindfulness meditation training modulated somatomotor network-r…
Mindfulness meditation rewired brain networks for body awareness differently in healthy people versus those with depression, and these chang…
medRxiv Apr 3, 2026
Food aid provision associated with reduced anxiety and insomnia symptoms in food-insecure Pakistani adults
Psychiatry RCT
Food aid provision associated with reduced anxiety and insomnia symptoms in food-insecure Pakistani adults Can food aid help people sleep better? A study in Pakistan suggests it might
An exploratory RCT of 186 participants from food aid distribution centers in Pakistan found food aid provision was associated with significa…
In Pakistan, people receiving food aid reported less anxiety and better sleep than those waiting for help, suggesting hunger itself can keep…
Apr 3, 2026
CPAP therapy shows no significant reduction in cancer incidence among obstructive sleep apnea patients
Oncology Meta-analysis
CPAP therapy shows no significant reduction in cancer incidence among obstructive sleep apnea patients Does treating sleep apnea with CPAP lower your cancer risk? The answer isn't clear
A meta-analysis of three RCTs in OSA patients found no statistically significant difference in cancer incidence between CPAP and control gro…
Treating sleep apnea with CPAP does not appear to markedly reduce the risk of incident cancers, according to a new analysis of three large t…
Apr 2, 2026
FDA Approves Methylphenidate Hydrochloride Extended-Release Tablets for ADHD and Narcolepsy
Psychiatry FDA Approval
FDA Approves Methylphenidate Hydrochloride Extended-Release Tablets for ADHD and Narcolepsy The FDA has approved a new, longer-acting generic version of a common ADHD and narcolepsy medication
The FDA has approved methylphenidate hydrochloride extended-release tablets for the treatment of Attention Deficit Hyperactivity Disorder (A…
The FDA approved a new generic ADHD and narcolepsy medicine that works for about 8 hours, offering a longer-lasting option for patients 6 ye…
FDA Mar 31, 2026
Insomnia's association with cognitive function studied in 170 bipolar disorder outpatients
Psychiatry
Insomnia's association with cognitive function studied in 170 bipolar disorder outpatients Study examines link between insomnia and thinking problems in bipolar disorder
An observational study examined 170 outpatients with bipolar disorder to assess insomnia's relationship with cognitive functioning.
People with bipolar disorder who struggle to sleep may also face thinking problems, though this study only shows a connection without provin…
Frontiers Mar 30, 2026

Questions about Sleep Disorders, Intrinsic

How do sleep disorders impact gait quality and fall risk in older adults?

Sleep disorders in older adults are linked to worse balance control and a higher chance of falling, even if walking speed does not change.

Full answer →
Are sleep problems linked to a higher risk of falling in older adults?

Yes, sleep problems are linked to a higher risk of falling in older adults, likely due to impaired gait quality and balance.

Full answer →
Can cannabis use affect my sleep disorders based on genetic studies?

Genetic studies show that cannabis use and sleep disorders share specific genetic risks, particularly for insomnia and nighttime activity levels.

Full answer →