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Home › Conditions › Traumatic Brain Injury

Traumatic Brain Injury

Part of Brain Injury

26 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Traumatic Brain Injury

129 trials tracked for Traumatic Brain Injury: 14 in phase 3 or 4 and 8 with published results. The most-cited published study has 119 citations.

129Trials tracked
14Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 5 Phase 3 9 Phase 2 22 Phase 1 5 Other / NA 88
  1. Phase 3 Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions Completed · 119 cited
  2. Phase 3 Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability Completed · 40 cited
  3. Phase 4 Methylphenidate for Attention Problems After Pediatric TBI Completed · 22 cited
  4. Phase 3 Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI Completed · 15 cited
  5. Phase 3 Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy Completed · 6 cited
  6. Phase 3 Inhaled Nitric Oxide in Brain Injury Completed · 4 cited
Show 44 more trials
  1. Phase 3 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients Completed · 3 cited
  2. Phase 4 Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression Completed
  3. Phase 4 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed
  4. Phase 4 Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits in Children Completed
  5. Phase 4 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed
  6. Phase 3 Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury Completed
  7. Phase 3 Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury Completed
  8. Phase 3 Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI) Completed
  9. Phase 2 DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury Completed
  10. Phase 2 A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy Completed
  11. Phase 2 Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI Completed
  12. Phase 2 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin Completed
  13. Phase 2 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed
  14. Phase 2 Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients Completed
  15. Phase 2 Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury Completed
  16. Phase 2 Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) Completed
  17. Phase 2 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI) Completed
  18. Phase 2 Clinical Evaluation of Flortaucipir F 18 Completed
  19. Phase 2 Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients Completed
  20. Phase 2 Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Completed
  21. Phase 2 Functional Connectivity as a Biomarker of rTMS Completed
  22. Phase 2 Ghrelin (OXE--103) for Acute Concussion Management Completed
  23. Phase 2 Prehospital Tranexamic Acid Use for Traumatic Brain Injury Completed
  24. Phase 2 A Study of Modified Stem Cells in Traumatic Brain Injury (TBI) Completed
  25. Phase 2 Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury. Completed
  26. Phase 2 Hyperbaric Treatment of Traumatic Brain Injury (TBI) Completed
  27. Phase 2 Cold-stored Platelet Early Intervention in TBI Completed
  28. Phase 2 Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) Completed
  29. Phase 2 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed
  30. Phase 2 Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin Completed
  31. Phase 1 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI) Completed
  32. Phase 1 DHA For The Treatment of Pediatric Concussion Related to Sports Injury Completed
  33. Phase 1 Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI) Completed
  34. Phase 1 Remediation of Impaired Self-Regulation in Patients With Mild TBI Completed
  35. Phase 1 Biological Signatures, Probiotic Among Those With mTBI and PTSD Completed
  36. N/A Traditional Balance vs Vibrotactile Feedback Training for Vestibular Rehabilitation Completed
  37. N/A Test of Chamber Pressure to Divers and Chamber Attendants Completed
  38. N/A Intervention to Change Attributions That Are Negative (ICAN) Completed
  39. N/A High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury Completed
  40. N/A Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury Completed
  41. N/A Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI? Completed
  42. N/A Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD Completed
  43. N/A Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury Completed
  44. N/A Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2) Completed

Showing the 50 most-cited and recently-updated of 129 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Preliminary study finds altered cortical activity during balance recovery in symptomatic mTBI
Physical Medicine & Rehab
Preliminary study finds altered cortical activity during balance recovery in symptomatic mTBI Small study finds brain activity differences during balance recovery after mild concussion
A preliminary investigation in 5 people with symptomatic mTBI and 5 controls found lower preparatory sensorimotor cortical beta-burst power …
After a mild concussion, the brain shows lower activity before balance tests and reacts faster when recovering from a push.
medRxiv Apr 3, 2026
US report describes nonfatal traumatic brain injury-related hospitalizations
Neurology
US report describes nonfatal traumatic brain injury-related hospitalizations How many Americans are hospitalized for nonfatal brain injuries?
An observational report describes nonfatal traumatic brain injury-related hospitalizations in the United States population.
Nonfatal brain injuries are a major public health concern in the United States, with many cases serious enough to require hospitalization.
CDC Apr 3, 2026

Research across Brain Injury

Related studies from across the Brain Injury family.

High-altitude ICU study finds 21% AKI incidence in neurocritical patients
Nephrology Cohort
High-altitude ICU study finds 21% AKI incidence in neurocritical patients High-altitude ICU patients face kidney injury risk
This retrospective cohort study of 390 adult neurocritical patients at a high-altitude ICU found that 83 patients (21.3%) developed acute ki…
A study of 390 adults in a high-altitude ICU found that 1 in 5 developed acute kidney injury, linked to older age and higher hemoglobin leve…
Frontiers Apr 24, 2026
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Infectious Disease Meta-analysis
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…
Apr 14, 2026
Cross-sectional survey examines concussion diagnosis prevalence in US children and adolescents
Neurology
Cross-sectional survey examines concussion diagnosis prevalence in US children and adolescents How many U.S. kids have been diagnosed with a concussion or brain injury?
A cross-sectional survey using National Health Interview Survey data examined the percentage of US children and adolescents aged ≤17 years w…
A national survey is waiting to reveal how many U.S. children and teens have ever received a diagnosis for a concussion or brain injury.
CDC Apr 3, 2026
Review suggests TWEAK-Fn14 axis contributes to brain injury and cardiac dysfunction pathology
Cardiology Sys. Review
Review suggests TWEAK-Fn14 axis contributes to brain injury and cardiac dysfunction pathology Review explores protein link between brain and heart diseases
A systematic review summarizes evidence on the TWEAK-Fn14 signaling pathway in cardio-cerebrovascular diseases.
High levels of two specific proteins linked to brain swelling and heart scarring may offer a future target for treating brain-heart syndrome…
Frontiers Apr 2, 2026

Questions about Traumatic Brain Injury

Can a non-invasive vagus nerve stimulation treatment help adults with chronic mild traumatic brain injury and PTSD?

Early evidence suggests non-invasive vagus nerve stimulation may reduce symptoms in adults with chronic mild TBI and PTSD, but more research is needed.

Full answer →
Can a machine learning model predict hospital death for ICU patients with traumatic brain injury?

Yes, machine learning models can predict hospital death for ICU patients with traumatic brain injury, with studies reporting over 80% accuracy.

Full answer →
How well does a machine learning model predict functional status after traumatic brain injury?

Machine learning models, particularly CatBoost, can predict functional outcomes after TBI with high accuracy (AUC up to 0.94), but most models need more external validation before routine clinical use.

Full answer →