Preclinical review suggests Danggui Sini Granule improves markers in a rat vasospastic CHD model
Danggui Sini Granule shows promise for heart disease in rats
This preclinical review examines the effects of Danggui Sini Granule in a rat model of vasospastic coronary heart disease. The authors synth…
A preclinical rat study suggests Danggui Sini Granule may improve heart markers and gut microbes in a specific disease model.
Inclisiran plus usual care improves LDL-C goal attainment after acute coronary syndrome
Inclisiran helps heart patients hit cholesterol goals fast
This phase 3b open-label RCT in 400 patients discharged after acute coronary syndrome found that adding inclisiran to usual care led to sign…
A new shot helped 3 in 4 recent heart attack patients reach LDL targets within 90 days, far more than usual care alone.
Meta-analysis shows PCI before TAVR reduces revascularization but increases bleeding risk in severe aortic stenosis patients with coronary artery disease
Routine PCI before TAVR doesn't save lives, increases bleeding
A meta-analysis of 1,156 patients found that performing PCI before TAVR did not lower mortality but significantly reduced the need for urgen…
For people with severe aortic stenosis and clogged arteries, routine angioplasty before valve replacement didn't reduce deaths but did raise…
Meta-analysis finds higher target-lesion revascularization with Magmaris scaffold vs. DES in ACS
Magnesium heart scaffold tied to more repeat procedures than standard stents
This meta-analysis of 622 patients compared Magmaris bioresorbable magnesium scaffold with drug-eluting stents in acute coronary syndrome. T…
A new magnesium heart scaffold dissolves over time, but a review finds it may lead to more repeat procedures than standard stents.
Guideline on cost-effectiveness of add-on ezetimibe for statin-intolerant acute coronary syndrome patients in Thailand
Add-on ezetimibe may be cost-effective for statin-intolerant patients in Thailand
This cost-utility analysis evaluates add-on ezetimibe versus moderate-intensity statin alone for acute coronary syndrome patients in Thailan…
Adding ezetimibe to moderate-intensity statin therapy appears cost-effective for patients in Thailand who cannot tolerate high-intensity sta…
Meta-analysis finds systemic lupus erythematosus elevates coronary artery disease risk
People with lupus face higher heart disease risk but genetics show no direct link
This meta-analysis of 2,517,781 individuals from European and East Asian populations found that systemic lupus erythematosus is associated w…
A massive analysis of millions of people found those with lupus have a much higher risk of heart disease, though genetics do not prove a dir…
Residual angina occurs in 42.2% of patients after anatomic complete revascularization for chronic coronary disease
Residual angina affects over 40% of patients after complete heart artery treatment
This randomized controlled trial evaluated symptomatic patients with chronic coronary disease undergoing invasive management. At six months,…
More than 40% of patients still have chest pain six months after complete heart artery treatment, impacting daily life and medication needs.
Systematic review and meta-analysis of drug-coated balloons versus drug-eluting stents in coronary artery disease
Meta-analysis links drug balloons to higher heart risks
This systematic review and meta-analysis evaluated drug-coated balloons (DCB) versus drug-eluting stents (DES) in 8,123 patients with corona…
A review of 8,123 patients found drug-coated balloons for heart arteries may raise risks of repeat procedures and cardiac death compared to …
Active cancer associated with higher mortality in acute coronary syndromes, PCI may mitigate risk
Patients with active cancer face higher death risk during heart attack hospital stays
This systematic review and meta-analysis of 1,154,050 patients with acute coronary syndromes found that active cancer was associated with si…
A large review of over one million patients shows that having active cancer greatly increases the risk of dying during a heart attack. Howev…
Systematic review and meta-analysis compares jailed balloon versus jailed wire techniques for bifurcation PCI
New Heart Stent Method Cuts Dangerous Complication Nearly 70 Percent
This systematic review and meta-analysis evaluated the jailed balloon technique (JBT) versus the jailed wire technique (JWT) in patients und…
• Jailed balloon technique slashes side branch blockage risk during heart stents • Helps patients needing complex artery splitting procedure…
OCT guidance showed non-significant MACE reduction in true unprotected left main bifurcation disease compared to angiography
Doctors used special imaging tools to help place stents in heart arteries safely
This randomized controlled trial enrolled 227 patients with true unprotected left main bifurcation lesions. Optical coherence tomography (OC…
A study tested using optical coherence tomography to guide stent placement in complex heart artery cases. While the imaging was mostly succe…
Narrative review explores strategic collaborations to expand interventional cardiology access in sub-Saharan Africa
Strategic partnerships help bring heart care services to people in sub-Saharan Africa
This narrative review examines how strategic collaborations can increase equitable access to interventional cardiology in sub-Saharan Africa…
This review looks at how working together can improve heart care in sub-Saharan Africa. It aims to close the gap for patients with coronary …
Research across Myocardial ischemia
Related studies from across the Myocardial ischemia family.
IVUS-guided PCI shows no significant difference over angiography-guided PCI for primary outcomes
Trial shows ultrasound imaging adds no benefit for heart surgery
This randomized controlled trial of 806 patients with unprotected left main coronary artery disease found that IVUS-guided PCI did not signi…
A large trial found that using ultrasound guidance during certain heart procedures did not improve safety or outcomes compared to standard m…
Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients
Timing of heart surgery does not change survival for a specific heart attack group
This meta-analysis reviewed 5077 patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease comparing …
A large review found that waiting for staged heart surgery did not improve survival or reduce heart attacks compared to immediate surgery fo…
Five-year economic and quality of life outcomes favor PCI with zotarolimus stents over CABG in 3-vessel CAD
Five-year follow-up reveals lower costs and better employment for PCI over surgery in complex heart disease
This randomized trial compared fractional flow reserve-guided PCI using zotarolimus drug-eluting stents with coronary artery bypass grafting…
Patients with complex heart disease treated with stents had lower costs and better quality of life than those who had surgery after five yea…
Retrospective cohort finds inverse triglyceride relationship with mortality in left main coronary artery disease
Low Fat, High Risk: Why Less Triglyceride Means Longer Life
This retrospective cohort study evaluated 2,778 patients with left main coronary artery disease undergoing percutaneous coronary interventio…
Imagine your heart is a busy highway. For years, doctors thought high cholesterol was the only traffic jam causing crashes.
Narrative review outlines practical framework for combined lipid and anti-inflammatory therapy in coronary atherosclerosis
Your Heart Has a Hidden Fire
This narrative review examines the role of colchicine and IL-1β inhibitors in patients with coronary atherosclerosis.
Doctors now know you must fight two enemies at once: the bad fats in your blood and the hidden inflammation that makes them dangerous.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
FFR-guided complete revascularization reduces unplanned revascularization in MI patients with multivessel CAD
Complete Heart Repair May Stop Future Emergencies
A meta-analysis of 3,054 patients with myocardial infarction and multivessel coronary artery disease found that FFR-guided complete revascul…
Fixing all blocked heart arteries during surgery may stop future emergencies and unplanned procedures for patients with heart attacks.
Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI
New study shows ticagrelor did not beat prasugrel for heart attack prevention in diabetics
This randomized clinical trial of 1,800 patients with diabetes and multivessel coronary artery disease undergoing PCI compared ticagrelor pl…
For diabetics with heart stents, a new study found ticagrelor offered no clear advantage over prasugrel in preventing death, heart attacks, …
iFR-guided CABG improves mid-term graft patency versus angiography alone in multivessel disease
Can a simple test during heart surgery help grafts stay open longer?
A single-blinded RCT in patients with multivessel disease and intermediate stenoses found iFR-guided CABG significantly improved LIMA-to-LAD…
A simple pressure test during heart surgery keeps new blood vessel grafts open longer, with 80.5% staying clear versus 56.8% with standard i…
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Questions about Coronary Artery Disease
Is having lower blood pressure at the start of treatment linked to higher risk in stable CAD?
Yes, a post-hoc analysis of the AFIRE trial found that in patients with atrial fibrillation and stable CAD, lower baseline systolic blood pressure (≤126 mmHg) was linked to higher cardiovascular risk compared to higher SBP.
Full answer →Can an AI model help doctors decide on my treatment plan for Percutaneous Coronary Intervention?
AI models are not yet proven to help doctors decide on PCI treatment plans; current research focuses on imaging and risk scores, not AI decision support.
Full answer →Does having metabolic syndrome increase my risk of restenosis after Percutaneous Coronary Intervention?
Current evidence does not show a clear link between metabolic syndrome and higher restenosis risk after PCI, though related factors like insulin resistance may play a role.
Full answer →Is proton pump inhibitor use increasing for Chinese patients with acute coronary syndrome?
Yes, PPI use is increasing among Chinese ACS patients, rising from 21.3% (2010-2012) to 63.5% (2016-2018) in one study, with over 60% prescribed PPIs in a 2017-2018 registry.
Full answer →What drug-drug interactions should I watch for while hospitalized with acute coronary syndrome?
While hospitalized for acute coronary syndrome, watch for interactions between blood thinners (aspirin, ticagrelor, heparin) and other drugs like ramipril, PPIs, and smoking cessation aids; your care team monitors these closely.
Full answer →Do SGLT-2 inhibitors help reduce heart failure hospitalization for acute coronary syndrome?
Yes, SGLT-2 inhibitors reduce the risk of first heart failure hospitalization in patients with acute coronary syndrome, according to a 2024 meta-analysis.
Full answer →Does using imaging guidance during stenting lower heart attack risk for older patients with coronary artery disease?
Yes, imaging guidance (IVUS or OCT) during stenting lowers heart attack and MACE risk in older patients, according to a 2024 meta-analysis of 9 RCTs.
Full answer →Can a CT scan accurately measure my coronary artery disease blockages compared to invasive tests?
CT scans (CCTA) can detect blockages but tend to underestimate their severity compared to invasive angiography, so they are not a perfect replacement.
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