Narrative review on sepsis and the microbiome, highlighting unresolved causality and variability
Could your sepsis treatment be missing a key clue about your unique biology?
This narrative review synthesizes current evidence on the microbiome in sepsis.
Sepsis treatment risks vary by biology because gut bacteria and genes drive inflammation, yet doctors currently lack tools to predict who wi…
MAIT cell frequency decreased in sepsis-related liver injury, with altered phenotype and function in murine models
Liver cells get help from immune defenders during sepsis
This observational cohort study in patients with sepsis-related liver injury (SRLI) and murine models found significantly decreased peripher…
During sepsis, immune defenders actually protect the liver instead of causing damage, offering new hope for patients losing liver function.
Insulin administration associated with lower 28-day mortality in non-diabetic sepsis patients
Insulin Might Help Sepsis Patients Survive Longer
This retrospective cohort study of 11,289 non-diabetic patients with sepsis found insulin administration was associated with reduced 28-day …
Insulin therapy was linked to a 37% lower risk of death in non-diabetic sepsis patients, though it extended hospital stays.
Corticosteroids reduce short-term and long-term mortality in adult sepsis patients according to a systematic review
What Doctors Give Sepsis Patients Is Finally Getting Clearer
This systematic review and network meta-analysis evaluated corticosteroids, specifically hydrocortisone and hydrocortisone plus fludrocortis…
Corticosteroids cut short-term and long-term sepsis death risk for ICU adults in large review, though doctors still need clearer guidance on…
Biomarkers and clinical factors show statistical associations with sepsis-induced coagulopathy in 37,459 patients
Your Blood May Signal a Deadly Clotting Crisis Before It Strikes
This systematic review and meta-analysis evaluated 37,459 patients to assess the association between various biomarkers and clinical factors…
Blood markers like glycocalyx degradation and low fibrinogen can predict deadly clotting in sepsis patients early, potentially saving lives …
Protein nutritional support in critically ill adults shows heterogeneous mortality benefits and potential harm from very high early doses
Why ICU Patients Need More Protein, But Not Too Much
This narrative review evaluates protein supplementation strategies in critically ill adults, including those with sepsis or severe burns.
Doctors caring for patients in the ICU know protein matters for recovery, but a new review shows the right dose depends on the illness, the …
Vital sign trajectories in early ICU sepsis thrombocytopenia link to mortality risk
Early ICU signs predict who needs extra care
A retrospective cohort study of adults with sepsis-associated thrombocytopenia in the ICU found that Cluster 2 (based on vital sign trajecto…
Tracking how your body changes in the first few hours of ICU care can help doctors spot danger early and adjust treatment plans before it ge…
Immune dysregulation score predicts mortality and identifies hydrocortisone responders in community-acquired pneumonia
Three Blood Markers May Pick Who Benefits From Sepsis Steroids
A multicohort analysis and reanalysis of an RCT developed and validated an immune dysregulation score using three plasma biomarkers in 398 d…
A simple three-blood-test model may finally pick which sepsis patients benefit most from steroid treatment, using biology instead of guesswo…
A 1-hour sepsis bundle is associated with reduced short-term mortality compared to non-bundle care in a meta-analysis of 4435 patients
One Hour Saves Lives in Sepsis
This systematic review and meta-analysis evaluated the association between a 1-hour sepsis bundle and short-term mortality in 4435 patients …
A specific 1-hour checklist for treating sepsis significantly lowers short-term death rates compared to standard care, offering a simple way…
RDW trajectories during sepsis hospitalization predict 30- and 90-day mortality in retrospective study
Why a simple blood test predicts who gets sicker
A retrospective cohort study of 3,813 sepsis patients found that specific red blood cell distribution width (RDW) trajectories over the firs…
Tracking how your red blood cell size changes day by day reveals who is most likely to die from sepsis within 30 days.
AI applications in acute care showed potential but face significant implementation challenges
AI Is Quietly Changing How ERs Save Lives. Here’s How
This narrative review examined artificial intelligence (AI) applications in patients within emergency departments and intensive care units.
Artificial intelligence is moving into emergency rooms to help doctors spot life-threatening problems faster, but it’s not ready to run the …
Macrophage glycolysis interactions modulate inflammation and polarization in sepsis
A Hidden Switch in Your Immune System Could Change Sepsis Treatment
This systematic review examined mechanisms linking macrophage glycolysis and inflammation in sepsis.
Understanding this biological energy switch gives researchers a clear new target to stop sepsis in its tracks.
Research across Systemic Inflammatory Response Syndrome
Related studies from across the Systemic Inflammatory Response Syndrome family.
Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
Antibiotic reduces maternal infection risk in labor
This secondary analysis of an RCT found that azithromycin reduced maternal infection and sepsis in women in labor, with a larger reduction a…
A single dose of azithromycin during labor lowered maternal infections in a large trial across seven countries.
Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
A New Blood Test May Spot Newborn Sepsis Faster Than Current Methods
This systematic review and meta-analysis of 495 neonates compared IL-27 to C-reactive protein for diagnosing neonatal sepsis. IL-27 showed h…
A simple blood marker called IL-27 catches newborn sepsis more accurately than the standard test, potentially saving lives by speeding up di…
7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
Can shorter antibiotics cure newborn sepsis just as well as two weeks of treatment?
This randomized control assessor-blinded trial evaluated 140 neonates weighing ≥ 1000 g with culture-positive sepsis in a tertiary Neonatal …
A 7-day antibiotic course for newborn sepsis worked as well as 14 days, with babies leaving the hospital sooner and needing less breathing s…
AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
Strategies to reduce antibiotic resistance may lower infection risks in newborns in low-income countries
A systematic review and meta-analysis of 31 facility-based studies in LMICs found that strategies to reduce antimicrobial resistance, includ…
Strategies to curb antibiotic resistance in newborns in low-income countries lower infection risks and reduce overall mortality.
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs
Can antiseptics on the umbilical cord save newborns from infection and death?
Meta-analysis shows 4.0% chlorhexidine reduces neonatal mortality (RR 0.86) and omphalitis (RR 0.71) in LMICs, but delays cord separation by…
Applying chlorhexidine to the umbilical cord may lower the risk of infection and death in newborns in low-income countries.
Questions about Sepsis
Does using procalcitonin to guide my sepsis care lower my chance of dying?
Yes, procalcitonin-guided care may lower your chance of dying from sepsis, with studies showing reduced 28-day and long-term mortality.
Full answer →What quality indicators should I expect for my sepsis care in China?
In China, sepsis care quality indicators include timely antibiotic administration, blood culture collection, lactate measurement, and fluid resuscitation, as outlined in a Delphi consensus study.
Full answer →Does having sepsis mean I will face long-term cognitive or physical problems?
Yes, sepsis survivors often face long-term cognitive, physical, and psychological problems known as post-sepsis syndrome, with impairments persisting for months to years.
Full answer →