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Cardiac Arrest

Subtypes of Cardiac Arrest

Out-of-Hospital Cardiac Arrest 6 Sudden Cardiac Death 4 Sudden cardiac arrest 1

29 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cardiac Arrest

45 trials tracked for Cardiac Arrest: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 473 citations.

45Trials tracked

5Phase 3 & 4

0Recruiting

3With published results

Phase distribution

Phase 4 1 Phase 3 4 Phase 2 6 Phase 1 1 Other / NA 33

Phase 3 Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia Completed · 473 cited
Phase 3 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial Completed · 437 cited
Phase 3 Biphasic Defibrillation Study: Trial to Compare Fixed Versus Escalating Energy Completed · 120 cited
Phase 4 Antiplatelet Therapy After Cardiac Arrest Completed
Phase 3 Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest Completed
Phase 2 Bicarbonate in Patients With Out-of-hospital Cardiac Arrest Completed

Show 39 more trials

Phase 2 Ubiquinol as a Metabolic Resuscitator in Post-Cardiac Arrest Completed
Phase 2 Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest Completed
Phase 2 Neuromuscular Blockade for Post-Cardiac Arrest Care Completed
Phase 2 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest Completed
Phase 2 Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation Completed
Phase 1 Reoxygenation After Cardiac Arrest II (REOX II Study) Completed
N/A A Digital Flu Intervention for People With Cardiovascular Conditions Completed
N/A Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims Completed
N/A Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial Completed
N/A Survey of Attitudes and Factors Associated With CPR in an Older Population Completed
N/A Open Pilot Trial of a Mind-body Program for Cardiac Arrest Survivors and Their Caregivers Completed
N/A Mastery Learning Versus Time-based Education: Skill Acquisition and Retention of Basic Life Support in Laypeople Completed
N/A Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot Completed
N/A Ultra-Brief Versus Brief Hands Only CPR Video Training With and Without Psychomotor Skill Practice Completed
N/A Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest Completed
N/A Pragmatic Airway Resuscitation Trial Completed
N/A Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events Completed
N/A Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning Completed
N/A Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest Completed
N/A Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock Completed
N/A MIHS Emergency Department CPR Quality Improvement Project Completed
N/A Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios. Completed
N/A Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR). Completed
N/A Code Blue Outcomes & Process Improvement Through Leadership Optimization Using Teleintensivists-Simulation Completed
N/A Bystander Fatigue and CPR Quality Using Continuous Compressions Versus 30:2 Compressions to Ventilation Completed
N/A A Survey of Factors Associated With the Successful Recognition of Agonal Breathing and Cardiac Arrest. Completed
N/A Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients Completed
N/A The Care After Life-threatening Medical Events Study Completed
N/A Acceptance and Mindfulness Based Exposure Therapy for Survivors of Cardiac Arrest Completed
N/A Improving Cardiac Arrest Diagnostic Accuracy of Emergency Medical Dispatchers Completed
N/A Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients Completed
N/A Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear) Completed
N/A Intraosseous Versus Intravenous Vascular Access During Cardiac Arrest Completed
N/A Impact of Speed Of Rewarming After CaRdiac Arrest and ThErapeutic Hypothermia Completed
N/A Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest Completed
N/A Circulation Improving Resuscitation Care (CIRC) Completed
N/A Pre-ROSC Intra-Nasal Cooling Effectiveness Completed
N/A ECPR for Refractory Out-Of-Hospital Cardiac Arrest Completed
N/A Effectiveness of Dispatch-Assisted Cardiopulmonary Resuscitation (CPR) Instructions Completed

Showing the 45 most-cited and recently-updated of 45 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Cardiac Arrest: what the trials found

Clinical management of cardiac arrest includes the use of amiodarone ⁴, clopidogrel ³, and adrenaline, the latter of which was evaluated for its impact on neurological status at discharge or 30 days post-arrest ⁷. Additionally, fixed lower-energy defibrillation has been studied regarding survival to 24 hours ⁶.

Therapeutic hypothermia is an established intervention; studies have assessed its impact on survival rates and neurobehavioral outcomes, with results showing no statistically significant difference in survival (p=0.13) or changes in neurobehavioral function from pre-arrest to 12 months post-arrest (p=0.13) ⁵. Furthermore, the incidence of death or poor neurologic outcome at 6 months was recorded following therapeutic hypothermia ²¹.

Recent results — preliminary, needs further review

Pre-arrival instructions for out-of-hospital cardiac arrest did not show a statistically significant difference in the incidence of bystander CPR (p=0.41) ².
An educational informational platform was associated with specific scores in mishel uncertainty, PTSD checklist, and cardiac anxiety fear subscales ¹⁵.
The 'Recovering Together' program showed high client satisfaction scores, improvements in credibility/expectancy scales, and a reduction in hospital depression and anxiety scale scores ¹⁶.

For the clinician treating this condition

Pharmacological interventions such as amiodarone ⁴, clopidogrel ³, and adrenaline ⁷ are established components of cardiac arrest management.
Therapeutic hypothermia is utilized to improve outcomes, though specific trials showed no statistically significant difference in survival or long-term neurobehavioral changes [5, 21].
Fixed lower-energy defibrillation has been evaluated for 24-hour survival ⁶.

AI synthesis of 9 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

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