Depression screening predicts lower health-related quality of life in ICU survivors
Depression and anxiety symptoms lower health quality for ICU survivors after leaving the hospital
This cross-sectional analysis of pre-randomization data from a randomized controlled trial evaluated 319 intensive care unit survivors. Depr…
A study of 319 ICU survivors found that depression and anxiety symptoms significantly reduce health quality. Screening for these issues is i…
Review of microbiota-informed approaches for adolescent depression notes limited causal evidence
New review suggests gut health may help teen depression but evidence is still limited
This narrative review examines the role of gut-brain axis perturbations, diet, and psychobiotics in adolescent depression. The authors synth…
A new review suggests that gut health and diet might help with teen depression, but direct proof in young people is still missing.
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Meta-analysis and preclinical study link Limosilactobacillus fermentum to depression
Probiotic shows promise for depression in early research
This meta-analysis and preclinical study found reduced abundance of Limosilactobacillus fermentum in patients with depression. In a mouse mo…
A probiotic strain may help depression by boosting mood-related brain chemicals and reducing inflammation, but only in mice so far.
Motherly app shows stronger depressive symptom reduction in women with fewer children and higher pediatric consultations
New app helps some new moms feel better when they have fewer kids and see doctors often
This secondary analysis of a randomized controlled trial evaluated the Motherly app in 264 women. Intervention effects on depressive symptom…
A phone app helped some new mothers feel less sad, but it worked best for those with fewer children. The study found that using the tool mor…
Systematic review and meta-analysis of MDMA-assisted therapy for trauma and depression
MDMA-assisted therapy shows promise for trauma and depression in mental illness
This systematic review and meta-analysis synthesized evidence on MDMA-assisted therapy for trauma and depression. It found significant moder…
A review of MDMA-assisted therapy found significant reductions in trauma and psychopathology compared to controls, though larger trials are …
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents
Mood stabilizers show promise for teen self-injury and depression in China
This systematic review and meta-analysis examined nine studies from China involving adolescent patients with nonsuicidal self-injury. The au…
A review of nine studies suggests mood stabilizers may help reduce self-injury and depression in Chinese adolescents, offering new options f…
Mind-body therapies reduce depression and anxiety in people with cancer, network meta-analysis finds
Mind-body therapies help cancer patients feel less depressed and anxious
This network meta-analysis of 16,835 people with cancer evaluated mind-body therapies versus usual care for depression and anxiety. Several …
People with cancer who used mind-body therapies like yoga or mindfulness felt significantly less depressed and anxious compared to usual car…
Meta-analysis review links anxiety and depression to reduced cognitive flexibility and decision-making
Anxiety and depression linked to reduced cognitive flexibility and decision-making
This meta-analysis review synthesizes evidence regarding the association between anxiety and depression with cognitive function. The authors…
A meta-analysis suggests anxiety and depression are associated with lower cognitive flexibility and decision-making abilities, though differ…
Yoga reduces depression in breast cancer patients across multiple treatment groups
Yoga reduces depression in breast cancer patients, meta-analysis finds
A meta-analysis of 21 studies shows yoga significantly lowers depression in breast cancer patients, with strong effect sizes across surgery,…
A meta-analysis of 21 studies found yoga significantly reduced depression levels in breast cancer patients, suggesting a useful complementar…
Systematic review and meta-analysis links intolerance of uncertainty to depression in children and adolescents
Kids' Fear of the Unknown Fuels Depression More Than We Thought
This systematic review and meta-analysis examined the association between intolerance of uncertainty and depression in children and adolesce…
• Fear of uncertainty strongly links to teen depression symptoms • Helps parents spot hidden emotional struggles early • Better child-specif…
Systematic review and meta-analysis of intranasal esketamine for treatment-resistant depression in real-world settings
Real-World Results Show Esketamine Cuts Depression Symptoms Fast
This systematic review and meta-analysis evaluates intranasal esketamine in adults with treatment-resistant depression across real-world set…
Depression symptoms dropped sharply and remission rates rose over three months in adults using esketamine nasal spray in routine clinics.
Questions about Depression
Do patients with perinatal depression show brain alterations compared to healthy controls?
Research shows that women with perinatal depression have measurable brain changes compared to healthy controls, including reduced activity in regulatory areas and increased activity in emotional centers.
Full answer →What is the prevalence of perinatal depression among women in Ethiopia?
Perinatal depression affects 20.1% to 25.8% of women in Ethiopia based on pooled meta-analysis, with individual studies reporting rates up to 32.2%.
Full answer →Is there a link between polygenic risk scores and major depression with anxiety?
Yes, polygenic risk scores for major depression show stronger associations with comorbid anxiety-depression cases than with depression alone, indicating a shared genetic link.
Full answer →How do technical and behavioral factors affect blood biomarker results for depression?
Technical factors (e.g., blood collection time, season) and behavioral factors (e.g., BMI, smoking, exercise) can significantly influence blood biomarker levels, potentially affecting depression-related results.
Full answer →Are there specific blood biomarkers that predict major depression outcomes in UK Biobank?
No specific blood biomarkers have been validated to predict major depression outcomes in UK Biobank; research is ongoing.
Full answer →Can psychedelic-assisted therapy be an effective treatment option for my major depression?
A 2024 systematic review found that psychedelic-assisted therapy does not show a clear advantage over traditional antidepressants for treating major depression when both are compared in open-label trials.
Full answer →Does aerobic exercise reduce postpartum depressive symptoms and improve quality of life?
Yes, multiple meta-analyses show aerobic exercise significantly reduces postpartum depressive symptoms and improves quality of life, with moderate to large effect sizes.
Full answer →Is Zurzuvae approved by the FDA for treating postpartum depression in adults?
Yes, the FDA approved Zurzuvae (zuranolone) on August 4, 2023, for treating postpartum depression in adults.
Full answer →All Depression Articles
- Review of microbiota-informed approaches for adolescent depression notes limited causal evidence
- Depression screening predicts lower health-related quality of life in ICU survivors
- Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
- Meta-analysis and preclinical study link Limosilactobacillus fermentum to depression
- Motherly app shows stronger depressive symptom reduction in women with fewer children and higher pediatric consultations
- Systematic review and meta-analysis of MDMA-assisted therapy for trauma and depression
- Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents
- Mind-body therapies reduce depression and anxiety in people with cancer, network meta-analysis finds
- Meta-analysis review links anxiety and depression to reduced cognitive flexibility and decision-making
- Yoga reduces depression in breast cancer patients across multiple treatment groups
- Systematic review and meta-analysis links intolerance of uncertainty to depression in children and adolescents
- Systematic review and meta-analysis of intranasal esketamine for treatment-resistant depression in real-world settings
- Narrative review examines exercise effects on anxiety, depression, and metabolic dysfunction without reported outcomes
- Meta-analysis of psychosocial interventions for older adults with subclinical depression and anxiety
- Network meta-analysis of non-pharmacological interventions for subthreshold depression in youth
- Exposure to T gondii linked to small psychiatric risks but causality remains uncertain in current reviews
- Meta-analysis links high homocysteine levels to worse cognitive scores in depression patients
- Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
- Psychological interventions significantly reduce anxiety and depression in cancer pain patients compared to conventional care
- Review of observational cohort links ACS cancer prevention guidelines to lower depression and anxiety symptoms
- CBT Chatbots Show Moderate Depression Relief But High Bias Limits Confidence In Anxiety Findings
- Systematic review and meta-analysis of mindfulness for post-stroke depression
- Multimodal stepped-prevention program fails to reduce suicidal thoughts in adolescents
- Systematic review finds no efficacy advantage for psychedelic-assisted therapy over traditional antidepressants in major depression
- Genotype-Guided SSRI Prescribing Shows No Short-Term Benefit but Higher Remission at 6 Months
- Maintenance antidepressants show no effect on happy face recognition in adults with recurrent depression
- Meta-analysis synthesizes evidence on cognitive triad and depressive symptoms
- Network meta-analysis reveals mind-body and combined exercise modalities significantly improve depressive and anxiety symptoms in cancer patients
- Meta-analysis finds high anxiety and depression prevalence in pediatric inflammatory bowel disease
- Digital single session reappraisal intervention affects social media interpretation bias in college students
- Preoperative Pain Education Reduces Postoperative Pain and Postpartum Depression After Cesarean
- Auricular Acupressure With Music Therapy Reduces Labor Pain and Postpartum Depression
- Systematic review shows regional differences in HS comorbidity prevalence across North America, Europe, and Asia
- Naltrexone-Bupropion Aids Weight Loss in Overweight Adults With Depression
- Self-help mindfulness and CBT interventions reduce depression and anxiety in distressed students
- Digital mental health intervention reduces anxiety and depression in Chinese high school students
- Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
- Meta-analysis finds NLRP3 inflammasome components upregulated in animal depression models
- Systematic review and meta-analysis of digital technology interventions for cognitive function and mood in older adults
- Sex differences in genetic correlation between ischaemic heart disease and depression found in 1.14 million European ancestry individuals
- Narrative review discusses pharmacological and lifestyle interventions for type 2 diabetes and psychological health
- Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients
- Review of miRNA associations with high-risk diabetes profiles in midlife women
- Narrative review explores microbiome mechanisms as a promising adjunctive avenue for managing depression, anxiety, bipolar disorder, and schizophrenia
- Electroacupuncture research trends for depression show shifting focus to mechanisms from 2005 to 2025
- Psychomotor retardation in depression linked to increased Parkinson's risk
- Executive function training reduces anxiety and depression in working adults, CBT app improves workplace well-being
- Perinatal depression prevalence in Ethiopian women ranges from 20.1% to 25.8% based on pooled meta-analysis data
- Fatigue and depression severity correlation in survivors of severe prolonged COVID-19
- Meta-analysis shows altered resting-state functional activity in postpartum depression brain regions
- Meta-analysis of voice acoustic parameters in depression finds nonsignificant frequency difference
- Protocol for COMPASS CBT pilot trial in forcibly displaced Venezuelan adults in Peru
- Observational Study Links Latitude and Genetics to Seasonal Affective Disorder Risk in Adults
- Meta-analysis finds prenatal psychological interventions reduce postpartum depression incidence
- Sodium oxybate and other drugs flagged for perinatal depression risk in pharmacovigilance analysis
- FDA Approves Zurzuvae (zuranolone) for Postpartum Depression in Adults
- Systematic review of Traditional Chinese Medicine for depression with unreported outcomes and safety data
- Systematic review and meta-analysis shows exercise improves depression and quality of life in hemodialysis patients
- Scoping review of mental health in sub-Saharan African university students during COVID-19
- Meta-analysis finds aerobic exercise reduces postpartum depressive symptoms and improves quality of life
- Review of P-NQLS psychometric validation in U.S. parents of children aged 6-18 years
- Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
- SCC DBS with at-home LFP data collection predicts stable recovery in treatment-resistant depression
- Intensive Short-Term Dynamic Psychotherapy showed large effects on depression in treatment-resistant depression patients
- High-frequency music therapy reduces stress in adult psychiatric inpatients compared to low-frequency sessions
- Systematic review and meta-analysis of CBT for depression in multiple sclerosis patients
- Meta-analysis on psychological interventions and early psychosis care for depression and psychosis
- Observational cohort links symptom severity subgroups to poorer functioning and brain volume in psychosis and depression risk
- Protocol for Randomized Clinical Trial of Acupuncture Versus Sham Acupuncture in Irritable Bowel Syndrome
- Elobixibat improved constipation in schizophrenia or depression patients during postmarketing surveillance in Japan
- Bayesian network meta-analysis of exercise interventions for depression and anxiety in cancer survivors
- Narrative review of TRD epidemiology and CYP2C19 genotypes in Pakistan
- Case-control study links impaired decision-making tasks to suicide attempts in depressed patients
- Polygenic risk scores show stronger associations with comorbid anxiety and depression cases in cohort studies
- Systematic review and meta-analysis on depression and anxiety prevalence in liver cirrhosis
- Narrative review links ceramide elevations to major depressive disorder and suicidal vulnerability
- Narrative review explores psychobiotics and lifestyle changes for chronic constipation-depression comorbidity
- Meta-analysis links diabetic retinopathy with anxiety and depression in over 383,000 patients
- FDA Approves Spravato (esketamine) for Treatment-Resistant Depression and Depressive Symptoms with Acute Suicidal Ideation in Adults
- Pilot RCT in veterans with depression finds no benefit from immediate PGx testing
- PRISM implementation support increased depression care pathway adoption in obstetric practices compared to standard care
- Meta-analysis finds machine learning models predict depression in diabetes with AUC 0.822
- Ten-week Baduanjin exercise improved sleep and mood in college students with Qi-deficiency constitution
- GP psychoeducation sessions show no significant effect on depressive symptoms in primary care patients
- Omega-3 supplementation reduces stress, anxiety, and depression in Saudi adults over three months
- Meta-analysis shows psychotherapy effect sizes vary by baseline depression severity compared to control conditions
- Women at high risk for postpartum depression prefer psychiatric clinics with low costs and short waits
- Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
- Anti-inflammatory diets show mental health benefits in adults, with most consistent improvements in depressive symptoms
- Self-reported racial discrimination associated with postpartum depression and low birth weight in pregnant women
- Mini-review examines natural product compounds in rodent depression models
- Chronic pain linked to 7.5-fold increase in severe depressive symptoms in UK Biobank analysis
- Narrative review examines depression-dementia relationship in aging populations
- Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV
- High-frequency rTMS plus exercise reduced craving and negative emotions in methamphetamine use disorder
- Frailty shows strong positive association with depression in older adults with coronary heart disease
- Phase 2 RCT finds AI-coached therapy improves depression and anxiety symptoms versus waitlist
- Cross-sectional study finds brain structure alterations in chronic pain and depression
- My Cosmos preliminary evaluation shows positive usability and acceptance among university students and mental health professionals
- Group singing intervention improves maternal communication and perceived attachment in postnatal depression
- Ten-session school-based mental health package reduces depressive and anxiety symptoms in Chinese adolescents compared to routine curriculum
- Digital journaling shows modest anxiety reduction in young adults with mild-to-moderate symptoms
- Meta-analysis finds emotional abuse most strongly linked to depression among child maltreatment forms
- Meta-analysis finds 23% subthreshold depression prevalence in patients with diabetes mellitus
- PCSK9 inhibitor initiation associated with lower depression risk versus statins in hyperlipidemia
- Prenatal depression screening uptake increased but diverged across language groups from 2019 to 2024
- TAO-TMS shows high response rates in a small naturalistic Asian treatment-resistant depression cohort compared to historical controls
- Cognitive-behavioral and interpersonal programs reduce depression and anxiety symptoms in adolescents
- Breathwork reduces anxiety, depression, and stress in paramedic students in 12-week RCT
- Diary intervention improves sleep and reduces stress in critically ill children and their parents
- Internet-based IPM+ intervention reduces depressive symptoms in pregnant women with antenatal depression
- Social isolation linked to health risks in empty-nest older adults, integrative review finds
- Mindfulness-Based Art Therapy and Stress Reduction Show Benefits for Oncology Nurses in RCT
- Serenity therapy reduces symptoms and improves coping in geriatric hemodialysis patients
- Meta-analysis finds moderate negative correlation between meaning in life and depression
- Observational study examines antidepressant use patterns by sex and marital status in US adults
- Ketogenic diet shows modest antidepressant benefit at 6 weeks in adults with treatment-resistant depression
- Observational study examines breakfast consumption and academic, mental health outcomes in US high school students
- AI visual psychophysiological analysis shows high sensitivity for depression screening in 98 outpatients
- Vitamin D deficiency associated with depression in adolescents and young adults, stronger in females
- Meta-analysis finds depression associated with elevated Parkinson's disease risk
- Discordant multimorbidity linked to poorer health status and higher healthcare use in Chinese adults
- Hypnotic cognitive therapy reduces pain intensity in adults with spinal cord injury
- Mindfulness meditation training modulates neural connectivity differently in healthy and depressed individuals
- Observational study links esketamine-induced mystical experiences to depression improvement in 45 patients
- Arthritis affects 22.7% of U.S. adults, projected to reach 78.4 million by 2040
- Observational report examines anxiety and depression trends in US adults during COVID-19
- Classroom-based transdiagnostic intervention reduces anxiety and depression in university students with elevated symptoms
- Patient treatment preference does not affect outcomes in treatment-resistant depression, secondary analysis finds
- Yoga and relaxation interventions show non-significant effects on psychological outcomes in pediatric cancer caregivers
- Meta-analysis finds distinct hedonic deficits in schizophrenia and depression
- Narrative review proposes combining rTMS and mindfulness for treatment-resistant depression
- Systematic review finds brain alterations in perinatal depression compared to healthy controls
- Telehealth CBT improves quality of life in veterans with Parkinson's disease and comorbid depression
- Online behavioral intervention increases physical activity and improves depression in newly diagnosed multiple sclerosis
- Color therapy shows reduced fatigue and depression, improved quality of life in Parkinson's patients
- Exercise reduces depression and anxiety symptoms across populations in meta-meta-analysis
- Nutrition interventions may improve depression, anxiety, and diabetes distress in adults with diabetes
- Review organizes pharmacological strategies targeting gut-brain axis for neurological and psychiatric disorders
- Antithrombotic agents may reduce symptoms in severe mental illness, but evidence is very low certainty
- Flood exposure associated with elevated odds of PTSD, depression, and anxiety in affected populations
- Narrative review examines IBD as clinical model for chronic inflammation-depression connection
- Review finds no single mental illness profile for terrorism among MENA youth
- Remimazolam noninferior to propofol for ICU sedation in postoperative cancer patients
- Cervical insufficiency associated with higher anxiety and depression scores in second-trimester pregnancy
- Exercise during adjuvant chemo reduces fatigue, depression in CRC patients
- Livelihood Intervention Reduces Food Insecurity and Depression in HIV-Affected Kenyan Adolescents
- CFT Improves Depression and Emotional Eating in Severe Obesity: RCT Results
- Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use